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Familial Risk of AAA in Sweden

5. mai 2026 oppdatert av: Rebecka Hultgren, Karolinska University Hospital

Familial Risk of Abdominal Aortic Aneurysm in Sweden

The aim is to study the prevalence of abdominal aortic aneurysm in first degree relatives and the risk to develop AAA in individuals with heredity for AAA compared with the population ( without heredity for AAA).The study i based on national registers in Sweden with high coverage and capacity of linkage between different registers.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Detaljert beskrivelse

The study is designed as a retrospective, descriptive case-control population based national study. By using national registers, eligible patients diagnosed with AAA during the time period 2010-2024 will be identified, ( treated and untreated). The time period includes when screening was established in Sweden resulting in a large cohort of diagnosed men. Hence, individuals with diagnosed with AAA will be identified through registers at the National health and bord of welfare (Cause of death register, National patient register, Discharge register). Matched controls by sex, age (+/- 1 year), region and income (low,medium, high) will be identified in a ratio of x 4 from Statistic Sweden. These individuals will then be linked to the multigeneration register for identification of their first degree relatoves (FDR). In the finalstep, the FDR will be linked to NBHW register in order to evaluate if the individuals are diagnosed with AAA (rAAA or iAAA) or not. Socioeconomic data and comorbidity will also be collected for FDR, indexperson and matched controls.

Overall aim: To improve the understanding of the hereditary patterns for aortic disease, with specific consideration of regional differences and sex.

Hypothesis: An increased risk to develop any aortic disease will be detected in persons with one or more first-degree-relatives diagnosed with an aortic disease, which will remain although standard adjustments will be considered (age, sex, comorbidity,socioeconomic status).

Aims: 1)To describe the risk for female and male first-degree relatives (FDR) to female and male persons diagnosed with AAA (index persons) to develop a diagnosed AAA,compared to the population. 2) Identification of possible predictive associated risk factors (modifiable/non-modifiable, protective or negative) age, sex, region, other cardiovascular diseases,comorbidities, several FDRs, socioeconomic situation, multilevel aortic disease thatinfluences the hereditary risk.3)To describe the distribution of female and male first-degree relatives (FDR) to female and male persons diagnosed with AAA (index persons) to be diagnosed with a ruptured AAA rather than intact AAA, compared to the population.

Studietype

Observasjonsmessig

Registrering (Antatt)

900000

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Sverige
      • Stockholm, Sverige
        • Karolinska Institutet

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Nei

Prøvetakingsmetode

Sannsynlighetsprøve

Studiepopulasjon

Individuals with the diagnose AAA or the cause of death AAA in Sweden 2010-2024. The first-degree relatives have been identified through the Swedish multigeneration register and then a register based identifiaction if having AAA or not. All men and female over 45 years old are included.

Beskrivelse

Inclusion Criteria:

-

Exclusion Criteria:

  • younger than 45 years.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Kohorter og intervensjoner

Gruppe / Kohort
Index cases
Individuals with diagnosed abdominal aortic aneurysm during 2010- 2024
First-degree relatives to index cases
First- degree relatives to index cases with AAA. Siblings, Parents, Children identified through the Multigeneration register.
Index controls
Control population to index cases based on sex, age, region and income.
First-degree relatives of controls
First-degree relatives of the control population (index controls). Individuals without familial AAA.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
The Familial risk of Abdominal Aortic Aneurysm in first-degree relatives compared with the population.
Tidsramme: Through study completion, data spanning 1952 to 2024
To describe the risk for female and male first-degree relatives (FDR) to female and male persons diagnosed with AAA (index persons) to develop a diagnosed AAA, compared to the population.
Through study completion, data spanning 1952 to 2024

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Heredity as a risk factor for AAA
Tidsramme: At time of AAA diagnosis, cases diagnosed between 2010 and 2024.

Hypothesis: Although factors as age, male sex and cardiovascular disease increases the risk for AAA, heredity will remain a risk factor for development of AAA after adjustment.

2) Identification of possible predictive associated risk factors (modifiable/non- modifiable, protective or negative) age, sex, region, other cardiovascular diseases, comorbidities, several FDRs, socioeconomic situation, multilevel aortic disease that influences the hereditary risk.
At time of AAA diagnosis, cases diagnosed between 2010 and 2024.

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Karolinska University Hospital

Samarbeidspartnere

Karolinska Institutet
Swedish Heart Lung Foundation

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. januar 2010

Primær fullføring (Antatt)

1. juni 2026

Studiet fullført (Antatt)

31. desember 2028

Datoer for studieregistrering

Først innsendt

15. april 2026

Først innsendt som oppfylte QC-kriteriene

5. mai 2026

Først lagt ut (Faktiske)

11. mai 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

11. mai 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

5. mai 2026

Sist bekreftet

1. mai 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • Karolinska Institutet (Annen identifikator: Karolinska Institutet)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

NEI

IPD-planbeskrivelse

Individual participant data will not be shared with external parties due to Swedish legislation on personal data protection (GDPR) and restrictions governing access to national health register data. Data will only be accessible to the research team named in the ethical approval

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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