- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT07584343
EMG of Gait Under Dual-Task in Parkinson Desease (EMG-DT-PD)
Electromyographic Activity of the Tibialis Anterior and Medial Gastrocnemius in Parkinson's Disease During Forward and Backward Gait Under Dual-Tasking: A Descriptive Study
In this observational study embedded within a randomized controlled trial, the investigators aim to characterize the activation patterns of the tibialis anterior and medial gastrocnemius muscles in the more rigid leg of patients with Parkinson's disease when performing walking tasks under dual cognitive-task conditions, which are known to increase the risk of falls in this population.
To this end, a control group without neurological disorders and with comparable sociodemographic characteristics will also be assessed.
The study seeks to determine whether significant changes occur in forward and backward gait as a function of the dual-task condition.
Studieoversikt
Status
Studietype
Registrering (Faktiske)
Kontakter og plasseringer
Studiesteder
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Sevilla
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Seville, Sevilla, Spania, 41015
- Sevilla, España
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-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- Ability to walk independently for at least 5 meters, both forward and backward, without the need for assistive devices or assistance from another person.
- Diagnosis of idiopathic Parkinson's disease made by a neurologist at Hospital Virgen Macarena.
- Hoehn and Yahr stage I-III.
- Being in the "ON" phase of antiparkinsonian medication during the assessment (approximately one hour after intake, when the pharmacokinetic curve of levodopa reaches its peak).
Exclusion Criteria:
- Presence of symptomatic musculoskeletal disorders affecting the lower limbs (LL) (relevant orthopedic surgery or leg length discrepancy > 1 cm), or other neurological conditions (stroke, neuropathies, etc.) that independently affect gait.
- Balance disorders due to other causes (vestibulopathy, severe orthostatic hypotension, etc.).
- Decompensated systemic diseases (cardiac disease, COPD, uncontrolled diabetes mellitus, etc.).
- Uncorrected visual impairments that may affect gait performance.
- Previous treatment with deep brain stimulation.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
|---|
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Parkinson Desease
Patients with Parkinson's disease recruited from the Parkinson's Association of Seville
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Healthy Subjects
Patients with similar sociodemographic characteristics without neurological disorders
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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%MIVC
Tidsramme: Baseline (Day 1)
|
It was calculated by expressing the Root Mean Square (RMS) value for each condition as a percentage of the Maximal Voluntary Contraction (MVC) obtained during the isometric test.
This approach ensures accurate quantification of neuromuscular effort, which is essential to minimize bias arising from anatomical and physiological differences between subjects.
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Baseline (Day 1)
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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CVM
Tidsramme: Baseline (Day 1)
|
The Maximal Voluntary Contraction (MVC) was established as the reference value for neuromuscular activation capacity for each muscle (TA and GM).
This variable was obtained as the mean of three repetitions of maximal isometric activation lasting 6 seconds, allowing standardization of muscle responses to the dynamic efforts performed during gait.
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Baseline (Day 1)
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Ratio (GM/TA)
Tidsramme: Baseline (Day 1)
|
It is calculated as the ratio of activation between the agonist and antagonist muscles during the gait cycle.
This index is used to assess muscle co-activation strategies and the mechanical efficiency of gait.
|
Baseline (Day 1)
|
Samarbeidspartnere og etterforskere
Publikasjoner og nyttige lenker
Hjelpsomme linker
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Synukleinopatier
- Nevrologiske manifestasjoner
- Hjernesykdommer
- Sykdommer i sentralnervesystemet
- Sykdommer i nervesystemet
- Nevrodegenerative sykdommer
- Bevegelsesforstyrrelser
- Parkinsonlidelser
- Basal ganglia sykdommer
- Patologiske tilstander, tegn og symptomer
- Tegn og symptomer
- Parkinsons sykdom
- Gangforstyrrelser, nevrologisk
Andre studie-ID-numre
- SICEIA-2025-000444
Plan for individuelle deltakerdata (IPD)
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Legemiddel- og utstyrsinformasjon, studiedokumenter
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