MEG and Aphantasia (MEGAPHANTASIA)
Cerebral Oscillations During Covert Actions in Aphantasia
Covert actions are cognitive processes that involves the motor system. They include motor imagery, movement preparation, action observation or action language. They imply mental simulations, based on activations of neural networks, involved in specific operations such as perceiving or acting. These mental phenomena have intrigued and still intrigue philosophers, psychologists, and neuroscientists, as they are complex and introspective processes, which play a major role in human cognition.
To decipher similarities and differences between these types of covert actions, the investigators will focus on persons living with aphantasia, which is a neurocognitive specificity present in a small proportion of the population (5 to 8%). Aphantasia is characterized by the alteration or the absence of explicit mental representations.
This population offers an ideal testbed to disentangle the involvement of cognitive and motor processes in different forms of covert actions.
By means of magnetoencephalography, this study aims to identify and compare brain patterns and their temporal dynamics in alpha and beta bands during covert actions in two groups of healthy volunteers: aphantasics and non-aphantasics (i.e., having a non-altered imagery capacity).
If covert actions indeed share brain networks, the investigators expect aphantasics to present reduced neural and behavioral activation during the explicit (i.e., motor imagery) and implicit (movement preparation, action language and action observation) forms of covert actions.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Studietype
Registrering (Antatt)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiekontakt
- Navn: Florent LEBON, PhD
- Telefonnummer: +336 450 445 26
- E-post: florent.lebon@univ-lyon1.fr
Studiesteder
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Bron, Frankrike
- CERMEP
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Ta kontakt med:
- Yves ROSSETTI, Professor
- Telefonnummer: +334.78.86.50.21
- E-post: yves.rossetti@inserm.fr
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Hovedetterforsker:
- Yves ROSSETTI, Professor
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
Tar imot friske frivillige
Beskrivelse
Inclusion Criteria:
- Aged 18 to 60 years
- Willing to actively participate in the study
- Having signed an informed consent form to participate in the study
Inclusion Failure Criteria:
Identification of individuals with and without aphantasia based on responses to a questionnaire validated in the literature: Vividness of Movement Imagery Questionnaire, second version (VMIQ-2):
Scores required for inclusion in the aphantasic group
- VMIQ-2: internal visual imagery score = 55-60
- VMIQ-2: kinesthetic imagery score = 55-60
Scores required for inclusion in the non-aphantasic group
- VMIQ-2: internal visual imagery score = 20-36
- VMIQ-2: kinesthetic imagery score = 20-36
Exclusion Criteria:
- Neurological or psychiatric disorders
- History of neurological or psychiatric disorders
- Sleep disorders that may affect data variability or quality, or participant cooperation and retention, as assessed by the principal investigator or co-investigator during the inclusion interview
- Volunteers presenting standard contraindications to MEG and MRI examinations:
- Presence of incompatible metal in the body (pacemaker, implanted pump including insulin pump, neurostimulator, cochlear implants or other hearing devices, metallic prosthesis, intracerebral/surgical aneurysm clips, implantable defibrillator, ferromagnetic foreign bodies in the eyes or brain in the upper body, ventriculoperitoneal shunt valves, dental braces or steel posts in root canals, ferromagnetic foreign bodies in the upper body)
- Claustrophobia
- Pregnant or breastfeeding women
- Individuals under guardianship, curatorship, or legal protection
- Individuals deprived of liberty
- Individuals undergoing psychiatric care
- Individuals admitted to a health or social institution for reasons other than clinical research
- Individuals not affiliated with a social security system or not beneficiaries of such a system
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Ikke-randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Eksperimentell: Aphantasics
Healthy individuals with altered mental imagery (score between 55 and 60 for each modality at the vividness of motor imagery questionnaire - second version)
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Before MEG and MRI, measure of vividness for internal visual imagery, external visual imagery and kinesthetic imagery (for 12 actions).
Within a single session, measure of brain oscillations during four types of covert actions (motor imagery, action observation, action language and movement preparation).
Anatomical MRI, performed once
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Aktiv komparator: Non-aphantasics
Healthy individuals with non-altered mental imagery (score between 20 and 36 for each modality at the vividness of motor imagery questionnaire - second version)
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Before MEG and MRI, measure of vividness for internal visual imagery, external visual imagery and kinesthetic imagery (for 12 actions).
Within a single session, measure of brain oscillations during four types of covert actions (motor imagery, action observation, action language and movement preparation).
Anatomical MRI, performed once
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Whole-brain power of beta band (Tesla2)
Tidsramme: During MEG recording
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Power of beta band with whole brain analysis during each of the four covert actions (motor imagery, action observation, movement preparation and action language).
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During MEG recording
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Whole-brain power of alpha band (Tesla2)
Tidsramme: During MEG recording
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Power of alpha band with whole brain analysis during each of the four covert actions (motor imagery, action observation, movement preparation and action language).
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During MEG recording
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Power of beta band (Tesla2) in the primary motor cortex
Tidsramme: During MEG recording
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Power of beta band in M1 during each of the four covert actions (motor imagery, action observation, movement preparation and action language).
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During MEG recording
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Power of alpha band (Tesla2) in the primary motor cortex
Tidsramme: During MEG recording
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Power of alpha band in M1 during each of the four covert actions (motor imagery, action observation, movement preparation and action language).
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During MEG recording
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Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Yves ROSSETTI, Professor, Hospices Civils de Lyon
- Studieleder: Florent LEBON, PhD, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM UR7424)
Studierekorddatoer
Studer hoveddatoer
Studiestart (Antatt)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Andre studie-ID-numre
- 69HCL26_0176
- 2026-A01303-48 (Annen identifikator: ID-RCB)
Legemiddel- og utstyrsinformasjon, studiedokumenter
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