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Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke

14. juni 2026 oppdatert av: Prof. Wang Man-Ping, The University of Hong Kong

Build to Quit 「築建無煙」: Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke: A Pragmatic, Pilot, Cluster Randomized Controlled Trial

The goal of this pilot trial is to learn if 1-week NRT sampling, 3-week chewing gum, and 12-week chatbot-delivered instant messaging support works to help smoking cessation in construction workers who smoke. It will also learn about the feasibility, acceptability, and preliminary effectiveness of delivering the comprehensive intervention in construction settings. The main questions it aims to answer are:

  1. Will the integrated intervention, comprising NRT sampling, chewing gum, and chatbot-delivered instant messaging support, show feasibility, acceptability, and appropriateness for delivery in construction worksite settings?
  2. Will participants who receive the comprehensive intervention have a higher validated abstinence rate than those who receive NRT sampling alone?

Researchers will compare the integrated intervention, comprising NRT sampling, chewing gum, and chatbot-delivered instant messaging support, to the standard care group (NRT sampling alone) to see if the integrated intervention works to promote smoking cessation.

Participants in the intervention group will receive:

  1. AWARD advice and brief video
  2. 1-week NRT sampling
  3. 3-week chewing gum
  4. 12-week chatbot-based instant messaging support (via WhatsApp)

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Hong Kong has achieved a sustained reduction in daily cigarette smoking, from 23.3% in the early 1980s to 8.5% in 2025. However, the current prevalence remains above the Government's Towards 2025 target of 7.8%, indicating the need for continued and targeted cessation efforts. The construction industry represents a particularly important setting for intervention, as recent legislative amendments to designate construction sites as no-smoking areas have further strengthened the policy basis for promoting smoke-free worksites.

Construction workers (CWs) are a high-priority population for smoking cessation because they have consistently higher smoking prevalence than many other occupational groups and the general population. In Hong Kong, a workplace health study found that 45% of construction workers were daily smokers, nearly twice the prevalence among office clerks/professionals. For CWs, smoking may compound existing occupational health risks by increasing susceptibility to respiratory and cardiovascular diseases in a physically demanding and dust-exposed work environment.

This study proposes a comprehensive worksite-targeted smoking cessation intervention model for CWs who smoke in Hong Kong, integrating NRT sampling, chewing gum support, and chatbot-delivered instant messaging. NRT is an evidence-based pharmacotherapy for reducing nicotine withdrawal symptoms and supporting smoking abstinence, and has been widely used in community-based cessation interventions. For CWs, short-term NRT sampling may provide immediate access to evidence-based pharmacological support, reduce early withdrawal symptoms, and lower the initial barrier to treatment uptake in a worksite setting. Chewing gum may complement NRT sampling by serving as a low-cost behavioral substitute for smoking, particularly by replacing the hand-to-mouth and oral routines associated with cigarette use. Chatbot-delivered instant messaging support can further extend the intervention beyond the worksite by providing 24/7 support, reminders for NRT and chewing gum use, and real-time assistance during cravings or high-risk smoking situations.

Studietype

Intervensjonell

Registrering (Antatt)

200

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

  • Navn: Man Ping Wang, PhD
  • Telefonnummer: +852 3917 6636
  • E-post: mpwang@hku.hk

Studer Kontakt Backup

Studiesteder

  • Hong Kong
    • Hong Kong
      • Hong Kong, Hong Kong, Hong Kong, 999077
        • Hong Kong Council on Smoking and Health (COSH)
        • Ta kontakt med:
          • Fung Wong
          • Telefonnummer: +852 2180 5186
        • Underetterforsker:
          • Tai Hing Lam, MD
        • Underetterforsker:
          • Tzu Tsun Luk, PhD
        • Underetterforsker:
          • Xiaoyun Xie, MPH
        • Underetterforsker:
          • Mengyao Li, Mphil
        • Underetterforsker:
          • Ziqiu Guo, PhD
        • Underetterforsker:
          • Yilan Wu, Mphil

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Nei

Beskrivelse

Inclusion Criteria:

  1. Hong Kong residents aged 18 or above
  2. Smoke at least one cigarette per day in the preceding 3-month
  3. Able to communicate in Cantonese (including reading and writing Chinese)
  4. Saliva cotinine 30 ng/ml or above
  5. Intent to quit / reduce smoking
  6. Have instant messaging tool (WhatsApp) installed
  7. Able to use instant messaging tool (e.g., WhatsApp) for communication.

Exclusion Criteria:

  1. Smokers who are participating in other smoking cessation programmes
  2. Smokers who are using any smoking cessation medication
  3. Smokers who are presenting with the following oral diseases, including recent oral surgery or tooth extraction, unstable dentures, significant tooth mobility or advanced periodontal disease, temporomandibular pain or dysfunction, or painful oral mucosal lesions

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Helsetjenesteforskning
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Enkelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Intervensjonsgruppe
Atferdsmessig: Selvhjelpshefte for røykeslutt
Innholdet inkluderer informasjon om fordelene ved å slutte, røyke og sykdommer, metoder for å slutte, hvordan man håndterer abstinenssymptomer, erklæring om å slutte mv.
Atferdsmessig: Tildelingsråd
Tildelingsråd inkluderer spør om røykehistorie, advare om den høye risikoen, anbefaler å slutte, henvise røykere til røykesluttingstjenester (med henvisningskort), og gjør det igjen.
Atferdsmessig: Henvisningskort
Innholdet består av kort informasjon og et høydepunkt av eksisterende røykeslutt -tjenester, kontaktmetoder, motivasjonsinformasjon og sterke støttende meldinger eller slagord.
Atferdsmessig: Brief leaflet on health warning and smoking cessation
The contents of the leaflet include (1) highlights of the absolute risk of death due to smoking; (2) the whole list of diseases caused by active and secondhand smoking; (3) ten horrible pictorial warnings of health consequences of smoking and second-hand smoking in one page to maximize the impacts; (4) benefits of SC and (5) simple messages to encourage participants to quit smoking.
Legemiddel: 1-week nicotine gum
Participants in both group will receive a 1-week supply of free nicotine gum (2 mg or 4 mg). The dosage of nicotine gum will be guided by participants' daily cigarette consumption, in accordance with recommendations from the Department of Health. Research assistants will explain the benefits of NRT for smoking cessation, provide instructions on the correct use of nicotine gum, encourage participants to continue using nicotine gum after completing the free sample where appropriate, and advise participants to reduce smoking or make a quit attempt when using NRT.
Atferdsmessig: 3-week chewing gum
Participants in the intervention group will receive 6 packs of chewing gum at baseline (2 packs per week). Chewing gum will be presented as a practical strategy to replace the hand-to-mouth and oral routines associated with smoking, particularly during work breaks, after meals, in other smoking-related situations at construction sites, or when participants are unwilling to use nicotine gum.
Atferdsmessig: 12-week chatbot-based instant messaging support
Participants in the intervention group will receive 12 weeks of instant messaging support delivered by the LLM-based chatbot accessible via WhatsApp platform. The chatbot, powered by Claude model (or more advanced model available) using prompt-engineering and agent-based techniques, will deliver theory-based and structured intervention alongside freeform, on-demand support. The structured intervention session deploys the 5As model (Ask, Advise, Assess, Assist, and Arrange follow-up) and 5Rs model (Relevance, Risks, Rewards, Roadblocks, Repetition), as used in our previous telephone-counselling trials and recommended by WHO for brief SC intervention.
Atferdsmessig: Brief video
Participants in both groups will receive a brief motivational video (15-second) via WhatsApp. The video will feature a construction worker who successfully quit smoking in our previous trial, providing a relatable peer role model for participants. The video will welcome participants to the programme, encourage them to make a quit attempt, and promote early use of nicotine gum as a practical strategy for managing cravings and supporting smoking cessation.
Aktiv komparator: Kontrollgruppe
Atferdsmessig: Selvhjelpshefte for røykeslutt
Innholdet inkluderer informasjon om fordelene ved å slutte, røyke og sykdommer, metoder for å slutte, hvordan man håndterer abstinenssymptomer, erklæring om å slutte mv.
Atferdsmessig: Tildelingsråd
Tildelingsråd inkluderer spør om røykehistorie, advare om den høye risikoen, anbefaler å slutte, henvise røykere til røykesluttingstjenester (med henvisningskort), og gjør det igjen.
Atferdsmessig: Henvisningskort
Innholdet består av kort informasjon og et høydepunkt av eksisterende røykeslutt -tjenester, kontaktmetoder, motivasjonsinformasjon og sterke støttende meldinger eller slagord.
Atferdsmessig: Brief leaflet on health warning and smoking cessation
The contents of the leaflet include (1) highlights of the absolute risk of death due to smoking; (2) the whole list of diseases caused by active and secondhand smoking; (3) ten horrible pictorial warnings of health consequences of smoking and second-hand smoking in one page to maximize the impacts; (4) benefits of SC and (5) simple messages to encourage participants to quit smoking.
Legemiddel: 1-week nicotine gum
Participants in both group will receive a 1-week supply of free nicotine gum (2 mg or 4 mg). The dosage of nicotine gum will be guided by participants' daily cigarette consumption, in accordance with recommendations from the Department of Health. Research assistants will explain the benefits of NRT for smoking cessation, provide instructions on the correct use of nicotine gum, encourage participants to continue using nicotine gum after completing the free sample where appropriate, and advise participants to reduce smoking or make a quit attempt when using NRT.
Atferdsmessig: Brief video
Participants in both groups will receive a brief motivational video (15-second) via WhatsApp. The video will feature a construction worker who successfully quit smoking in our previous trial, providing a relatable peer role model for participants. The video will welcome participants to the programme, encourage them to make a quit attempt, and promote early use of nicotine gum as a practical strategy for managing cravings and supporting smoking cessation.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Biokjemisk validert abstinens
Tidsramme: 6 måneders oppfølging
Definert som utåndet CO-nivå <4ppm og spyttkotininnivå ≤30 ng/ml
6 måneders oppfølging

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Biokjemisk validert abstinens
Tidsramme: 3 måneders oppfølging
Definert som utåndet CO-nivå <4ppm og spyttkotininnivå ≤30 ng/ml
3 måneders oppfølging
Selvrapportert 7-dagers poengutbredelse avholdenhet
Tidsramme: 3- og 6-måneders oppfølging
Røykere som ikke røyk
3- og 6-måneders oppfølging
Selvrapportert reduksjon
Tidsramme: 1-, 2-, 3- og 6-måneders oppfølging
Definert av minst 50% reduksjon i baseline daglig antall sigaretter
1-, 2-, 3- og 6-måneders oppfølging
Selvrapportert bruk av røykesluttstjeneste
Tidsramme: 1-, 2-, 3- og 6-måneders oppfølging
Bruk av røykesluttstjeneste ved 1-, 2-, 3- og 6-måneders oppfølging.
1-, 2-, 3- og 6-måneders oppfølging
Family well-being
Tidsramme: 3- and 6-month follow-ups
Family well-being will be assessed using the 3H scale, which measures perceived family health, happiness, and harmony on a 0-10 scale.
3- and 6-month follow-ups
Perceived family happiness
Tidsramme: 3- and 6-month follow-ups
Perceived family happiness will be measured using a single-item self-reported family happiness scale ranging from 0 to 10.
3- and 6-month follow-ups

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Recruitment rate
Tidsramme: Baseline
Defined as the number of participants divided by the number of eligible smokers
Baseline
Retention rate
Tidsramme: 1-, 2-, 3- and 6-month follow-ups
Defined as the number of participants who completed the follow-up divided by the number of participants
1-, 2-, 3- and 6-month follow-ups
Acceptability of NRT sampling
Tidsramme: 1-, 2-, 3- and 6-month follow-ups
Acceptability of NRT sampling will be assessed through 4 brief items (score range from 0 to10) on perceived usefulness for craving relief, perceived side effects, willingness to continue using NRT after the free sample, and overall satisfaction with the NRT gum.
1-, 2-, 3- and 6-month follow-ups
Acceptability of chewing gum
Tidsramme: 1-, 2-, 3- and 6-month follow-ups
Acceptability of chewing gum will be assessed through 3 brief items (score range from 0 to 10) on perceived usefulness for behavioral substitution, perceived fit with construction worksite routines, and willingness to continue using chewing gum as a cessation aid.
1-, 2-, 3- and 6-month follow-ups
Self-reported adverse events
Tidsramme: 1-, 2-, 3- and 6-month follow-ups
Self-reported adverse events related to nicotine gum and chewing gum will be assessed using a binary question: "Have you experienced any adverse events when using nicotine gum or chewing gum?"
1-, 2-, 3- and 6-month follow-ups
Chatbot usability
Tidsramme: 3-month follow-up
Chatbot usability will be evaluated using the 11-item Bot Usability Scale (BUS), which assesses perceived effectiveness, efficiency, and satisfaction. The score of the Bot Usability Scale ranges from 0 to 100, with the higher score indicating more usability of the chatbot.
3-month follow-up

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

The University of Hong Kong

Etterforskere

  • Hovedetterforsker: Man Ping Wang, PhD, The University of Hong Kong

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

20. juni 2026

Primær fullføring (Antatt)

31. mai 2027

Studiet fullført (Antatt)

30. juni 2027

Datoer for studieregistrering

Først innsendt

9. juni 2026

Først innsendt som oppfylte QC-kriteriene

9. juni 2026

Først lagt ut (Faktiske)

15. juni 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

17. juni 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

14. juni 2026

Sist bekreftet

1. juni 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • Build to Quit

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