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Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients (POCDTURMSTUD)

20. juli 2026 oppdatert av: Eylem Yaşar, Muğla Sıtkı Koçman University

Prediction of Postoperative Cognitive Dysfunction and Delirium: A Prospective Observational Study to Develop a Risk Score in Elderly Patients Undergoing Transurethral Resection

Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality of life. Identifying patients who are more likely to develop postoperative cognitive dysfunction or delirium remains a practical challenge in daily clinical practice. Better recognition of these patients may help tailor perioperative care and improve outcomes.

This prospective observational study aims to identify perioperative factors associated with POCD and delirium in elderly patients undergoing transurethral resection and to develop a clinically applicable risk prediction model. Cognitive function and delirium are assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

Cognitive function and delirium will be evaluated using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

The results of this study may support clinicians in recognizing vulnerable patients earlier and may contribute to more individualized perioperative management.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Diagnostisk test: Cognitive and Delirium Assessment (MoCA and CAM)

Detaljert beskrivelse

Postoperative cognitive dysfunction (POCD) and delirium are frequently encountered in elderly patients after surgery and are linked to unfavorable clinical outcomes. Transurethral resection procedures, which are commonly performed in this age group, may further increase this risk due to both patient-related and perioperative factors.

In this prospective observational cohort, patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital are followed to determine the incidence of POCD and delirium and to identify perioperative factors associated with their development.

Before surgery, demographic characteristics, comorbidities, frailty status, and baseline cognitive function are recorded. Baseline cognitive function is assessed using the Montreal Cognitive Assessment (MoCA). During surgery, the anesthesia technique, procedure duration, intraoperative hemodynamic changes, and perioperative events are recorded.

After surgery, cognitive function and delirium are assessed at predefined intervals using MoCA and the Confusion Assessment Method (CAM).

The primary objective is to identify factors independently associated with POCD and delirium. In addition, a prediction model is developed using multivariable logistic regression, and its performance is evaluated by receiver operating characteristic (ROC) analysis.

The results may help to better recognize patients at higher risk and support more tailored perioperative management strategies in elderly surgical populations.

Studietype

Observasjonsmessig

Registrering (Antatt)

150

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Navn: Eylem Yasar, MD
Telefonnummer: +905332392622
E-post: eylemtarakci@gmail.com

Studer Kontakt Backup

Navn: Melike Korkmaz Toker, MD
Telefonnummer: +905054747098
E-post: meltoker@gmail.com

Studiesteder

Tyrkia (Türkiye)
- - Muğla, Tyrkia (Türkiye), 48000
    - Rekruttering
    - Muğla Training and Research Hospital
    - Ta kontakt med:
      
      Eylem Yasar, MD
      
      Telefonnummer: +905332392622
      
      E-post: eylemtarakci@gmail.com
    - Ta kontakt med:
      
      Melike Korkmaz Toker, MD
      
      Telefonnummer: +90 505 474 7098
      
      E-post: meltoker@gmail.com

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Eldre voksen

Tar imot friske frivillige

Nei

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

The study population consists of patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital. These patients represent an elderly surgical population at risk for postoperative cognitive dysfunction and delirium. Participants are enrolled consecutively according to eligibility criteria and followed throughout the perioperative period.

Beskrivelse

Inclusion Criteria:

Age ≥65 years
Scheduled for transurethral resection procedure
ASA physical status I-III
Able to provide informed consent
Adequate cognitive function to complete preoperative assessment

Exclusion Criteria:

Pre-existing diagnosis of dementia or severe cognitive impairment (MoCA <18)
Severe visual or hearing impairment preventing cognitive assessment
History of psychiatric disease requiring antipsychotic or sedative medication
Neurological disorders associated with increased delirium risk (e.g., Parkinson's disease, epilepsy)
Inability to complete study assessments

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Incidence of postoperative cognitive dysfunction and delirium Tidsramme: Baseline (preoperative) and postoperative days 1, 2, and 3	Postoperative cognitive dysfunction and delirium assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). POCD is defined as a decline in MoCA score compared with baseline, and delirium is identified based on CAM criteria.	Baseline (preoperative) and postoperative days 1, 2, and 3

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Risk factors associated with POCD and delirium Tidsramme: From baseline (preoperative) through postoperative day 3	Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium. Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium.	From baseline (preoperative) through postoperative day 3
Performance of the predictive risk model Tidsramme: Through study completion (anticipated November 2026)	Assessment of the predictive model for POCD and delirium using multivariable logistic regression and receiver operating characteristic (ROC) curve analysis.	Through study completion (anticipated November 2026)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Muğla Sıtkı Koçman University

Etterforskere

Hovedetterforsker: Eylem Yasar, MD, Muğla Training and Research Hospital

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

5. april 2026

Primær fullføring (Antatt)

1. oktober 2026

Studiet fullført (Antatt)

15. november 2026

Datoer for studieregistrering

Først innsendt

13. juli 2026

Først innsendt som oppfylte QC-kriteriene

20. juli 2026

Først lagt ut (Faktiske)

22. juli 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)