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Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients (POCDTURMSTUD)

20 juli 2026 bijgewerkt door: Eylem Yaşar, Muğla Sıtkı Koçman University

Prediction of Postoperative Cognitive Dysfunction and Delirium: A Prospective Observational Study to Develop a Risk Score in Elderly Patients Undergoing Transurethral Resection

Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality of life. Identifying patients who are more likely to develop postoperative cognitive dysfunction or delirium remains a practical challenge in daily clinical practice. Better recognition of these patients may help tailor perioperative care and improve outcomes.

This prospective observational study aims to identify perioperative factors associated with POCD and delirium in elderly patients undergoing transurethral resection and to develop a clinically applicable risk prediction model. Cognitive function and delirium are assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

Cognitive function and delirium will be evaluated using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

The results of this study may support clinicians in recognizing vulnerable patients earlier and may contribute to more individualized perioperative management.

Studie Overzicht

Toestand

Werving

Conditie

Interventie / Behandeling

Diagnostische toets: Cognitive and Delirium Assessment (MoCA and CAM)

Gedetailleerde beschrijving

Postoperative cognitive dysfunction (POCD) and delirium are frequently encountered in elderly patients after surgery and are linked to unfavorable clinical outcomes. Transurethral resection procedures, which are commonly performed in this age group, may further increase this risk due to both patient-related and perioperative factors.

In this prospective observational cohort, patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital are followed to determine the incidence of POCD and delirium and to identify perioperative factors associated with their development.

Before surgery, demographic characteristics, comorbidities, frailty status, and baseline cognitive function are recorded. Baseline cognitive function is assessed using the Montreal Cognitive Assessment (MoCA). During surgery, the anesthesia technique, procedure duration, intraoperative hemodynamic changes, and perioperative events are recorded.

After surgery, cognitive function and delirium are assessed at predefined intervals using MoCA and the Confusion Assessment Method (CAM).

The primary objective is to identify factors independently associated with POCD and delirium. In addition, a prediction model is developed using multivariable logistic regression, and its performance is evaluated by receiver operating characteristic (ROC) analysis.

The results may help to better recognize patients at higher risk and support more tailored perioperative management strategies in elderly surgical populations.

Studietype

Observationeel

Inschrijving (Geschat)

150

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studiecontact

Naam: Eylem Yasar, MD
Telefoonnummer: +905332392622
E-mail: eylemtarakci@gmail.com

Studie Contact Back-up

Naam: Melike Korkmaz Toker, MD
Telefoonnummer: +905054747098
E-mail: meltoker@gmail.com

Studie Locaties

Turkije (Türkiye)
- - Muğla, Turkije (Türkiye), 48000
    - Werving
    - Muğla Training and Research Hospital
    - Contact:
      
      Eylem Yasar, MD
      
      Telefoonnummer: +905332392622
      
      E-mail: eylemtarakci@gmail.com
    - Contact:
      
      Melike Korkmaz Toker, MD
      
      Telefoonnummer: +90 505 474 7098
      
      E-mail: meltoker@gmail.com

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

Oudere volwassene

Accepteert gezonde vrijwilligers

Nee

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

The study population consists of patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital. These patients represent an elderly surgical population at risk for postoperative cognitive dysfunction and delirium. Participants are enrolled consecutively according to eligibility criteria and followed throughout the perioperative period.

Beschrijving

Inclusion Criteria:

Age ≥65 years
Scheduled for transurethral resection procedure
ASA physical status I-III
Able to provide informed consent
Adequate cognitive function to complete preoperative assessment

Exclusion Criteria:

Pre-existing diagnosis of dementia or severe cognitive impairment (MoCA <18)
Severe visual or hearing impairment preventing cognitive assessment
History of psychiatric disease requiring antipsychotic or sedative medication
Neurological disorders associated with increased delirium risk (e.g., Parkinson's disease, epilepsy)
Inability to complete study assessments

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat	Maatregel Beschrijving	Tijdsspanne
Incidence of postoperative cognitive dysfunction and delirium Tijdsspanne: Baseline (preoperative) and postoperative days 1, 2, and 3	Postoperative cognitive dysfunction and delirium assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). POCD is defined as a decline in MoCA score compared with baseline, and delirium is identified based on CAM criteria.	Baseline (preoperative) and postoperative days 1, 2, and 3

Secundaire uitkomstmaten

Uitkomstmaat	Maatregel Beschrijving	Tijdsspanne
Risk factors associated with POCD and delirium Tijdsspanne: From baseline (preoperative) through postoperative day 3	Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium. Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium.	From baseline (preoperative) through postoperative day 3
Performance of the predictive risk model Tijdsspanne: Through study completion (anticipated November 2026)	Assessment of the predictive model for POCD and delirium using multivariable logistic regression and receiver operating characteristic (ROC) curve analysis.	Through study completion (anticipated November 2026)

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Muğla Sıtkı Koçman University

Onderzoekers

Hoofdonderzoeker: Eylem Yasar, MD, Muğla Training and Research Hospital

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

5 april 2026

Primaire voltooiing (Geschat)

1 oktober 2026

Studie voltooiing (Geschat)

15 november 2026

Studieregistratiedata

Eerst ingediend

13 juli 2026

Eerst ingediend dat voldeed aan de QC-criteria

20 juli 2026

Eerst geplaatst (Werkelijk)

22 juli 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)