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Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients (POCDTURMSTUD)

20 juli 2026 uppdaterad av: Eylem Yaşar, Muğla Sıtkı Koçman University

Prediction of Postoperative Cognitive Dysfunction and Delirium: A Prospective Observational Study to Develop a Risk Score in Elderly Patients Undergoing Transurethral Resection

Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality of life. Identifying patients who are more likely to develop postoperative cognitive dysfunction or delirium remains a practical challenge in daily clinical practice. Better recognition of these patients may help tailor perioperative care and improve outcomes.

This prospective observational study aims to identify perioperative factors associated with POCD and delirium in elderly patients undergoing transurethral resection and to develop a clinically applicable risk prediction model. Cognitive function and delirium are assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

Cognitive function and delirium will be evaluated using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM).

The results of this study may support clinicians in recognizing vulnerable patients earlier and may contribute to more individualized perioperative management.

Studieöversikt

Status

Rekrytering

Betingelser

Intervention / Behandling

Diagnostiskt test: Cognitive and Delirium Assessment (MoCA and CAM)

Detaljerad beskrivning

Postoperative cognitive dysfunction (POCD) and delirium are frequently encountered in elderly patients after surgery and are linked to unfavorable clinical outcomes. Transurethral resection procedures, which are commonly performed in this age group, may further increase this risk due to both patient-related and perioperative factors.

In this prospective observational cohort, patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital are followed to determine the incidence of POCD and delirium and to identify perioperative factors associated with their development.

Before surgery, demographic characteristics, comorbidities, frailty status, and baseline cognitive function are recorded. Baseline cognitive function is assessed using the Montreal Cognitive Assessment (MoCA). During surgery, the anesthesia technique, procedure duration, intraoperative hemodynamic changes, and perioperative events are recorded.

After surgery, cognitive function and delirium are assessed at predefined intervals using MoCA and the Confusion Assessment Method (CAM).

The primary objective is to identify factors independently associated with POCD and delirium. In addition, a prediction model is developed using multivariable logistic regression, and its performance is evaluated by receiver operating characteristic (ROC) analysis.

The results may help to better recognize patients at higher risk and support more tailored perioperative management strategies in elderly surgical populations.

Studietyp

Observationell

Inskrivning (Beräknad)

150

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studiekontakt

Namn: Eylem Yasar, MD
Telefonnummer: +905332392622
E-post: eylemtarakci@gmail.com

Studera Kontakt Backup

Namn: Melike Korkmaz Toker, MD
Telefonnummer: +905054747098
E-post: meltoker@gmail.com

Studieorter

Turkiet (Türkiye)
- - Muğla, Turkiet (Türkiye), 48000
    - Rekrytering
    - Muğla Training and Research Hospital
    - Kontakt:
      
      Eylem Yasar, MD
      
      Telefonnummer: +905332392622
      
      E-post: eylemtarakci@gmail.com
    - Kontakt:
      
      Melike Korkmaz Toker, MD
      
      Telefonnummer: +90 505 474 7098
      
      E-post: meltoker@gmail.com

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

Äldre vuxen

Tar emot friska volontärer

Nej

Testmetod

Icke-sannolikhetsprov

Studera befolkning

The study population consists of patients aged 65 years and older undergoing transurethral resection at Mugla Training and Research Hospital. These patients represent an elderly surgical population at risk for postoperative cognitive dysfunction and delirium. Participants are enrolled consecutively according to eligibility criteria and followed throughout the perioperative period.

Beskrivning

Inclusion Criteria:

Age ≥65 years
Scheduled for transurethral resection procedure
ASA physical status I-III
Able to provide informed consent
Adequate cognitive function to complete preoperative assessment

Exclusion Criteria:

Pre-existing diagnosis of dementia or severe cognitive impairment (MoCA <18)
Severe visual or hearing impairment preventing cognitive assessment
History of psychiatric disease requiring antipsychotic or sedative medication
Neurological disorders associated with increased delirium risk (e.g., Parkinson's disease, epilepsy)
Inability to complete study assessments

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Vad mäter studien?

Primära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Incidence of postoperative cognitive dysfunction and delirium Tidsram: Baseline (preoperative) and postoperative days 1, 2, and 3	Postoperative cognitive dysfunction and delirium assessed using the Montreal Cognitive Assessment (MoCA) and the Confusion Assessment Method (CAM). POCD is defined as a decline in MoCA score compared with baseline, and delirium is identified based on CAM criteria.	Baseline (preoperative) and postoperative days 1, 2, and 3

Sekundära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Risk factors associated with POCD and delirium Tidsram: From baseline (preoperative) through postoperative day 3	Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium. Evaluation of perioperative variables (demographic characteristics, comorbidities, frailty status, anesthesia type, and intraoperative parameters) associated with the development of POCD and delirium.	From baseline (preoperative) through postoperative day 3
Performance of the predictive risk model Tidsram: Through study completion (anticipated November 2026)	Assessment of the predictive model for POCD and delirium using multivariable logistic regression and receiver operating characteristic (ROC) curve analysis.	Through study completion (anticipated November 2026)

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Muğla Sıtkı Koçman University

Utredare

Huvudutredare: Eylem Yasar, MD, Muğla Training and Research Hospital

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

5 april 2026

Primärt slutförande (Beräknad)

1 oktober 2026

Avslutad studie (Beräknad)

15 november 2026

Studieregistreringsdatum

Först inskickad

13 juli 2026

Först inskickad som uppfyllde QC-kriterierna

20 juli 2026

Första postat (Faktisk)

22 juli 2026

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)