Iris Structural Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients
Comparison of the Efficacy of Tamsulosin and Silodosin on Anatomical Iris Changes in Patients With Benign Prostatic Hyperplasia: A Single-blind Randomized Clinical Trial
Inhibition of alpha-1 adrenergic receptors by drugs such as tamsulosin and silodosin, which are prescribed for the treatment of benign prostatic hyperplasia, can lead to intraoperative floppy iris syndrome (IFIS) during cataract surgery. IFIS is a phenomenon characterized by a small, poorly dilating pupil and causes surgical difficulty.
Main objective: To determine and compare changes in the anatomical structure of the iris in patients with BPH before and after treatment with tamsulosin and silodosin.
Men aged 50 years and older with a definitive diagnosis of BPH who have no prior history of alpha-blocker use will be enrolled in one of the two treatment arms - tamsulosin or silodosin. Imaging will be performed using an MS-39 device (manufactured by CSO, Italy); assessments will be conducted at two time points - before the start of treatment and after three months of continuous drug use. At baseline and three months after treatment, using AS-OCT, the DMR and SMR regions and other ocular angle indices will be measured. Medication adherence will be assessed by counting the capsules used by each patient.
Specific Objectives:
- To determine changes in the dilator muscle region (DMR) under scotopic, mesopic, photopic, and post-dilation conditions from baseline to the third month in the tamsulosin & silodosin groups and compare them.
- To determine changes in SMR under scotopic, mesopic, photopic, and post-dilation conditions from baseline to the third month in the tamsulosin & silodosin groups and compare them.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Studietype
Registrering (Antatt)
Fase
- Fase 4
Kontakter og plasseringer
Studiekontakt
- Navn: Mohsen Pourazizi, Assistant Professor
- Telefonnummer: 98 + 09379578055
- E-post: m.pourazizi@yahoo.com
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Beskrivelse
Inclusion Criteria:
- Men ≥ 50 years old with a definitive diagnosis of BPH by a urologist colleague.
- Patients with moderate symptoms based on the International Prostate Symptom Score (IPSS): score 8 to 19
- No prior use of alpha-blockers (tamsulosin, silodosin, doxazosin, etc.)
- Satisfactory vision for imaging and acceptable scan quality according to device criteria.
- Consent to participate in the study
Exclusion Criteria:
- Insufficient image quality in assessments
- History of intraocular surgery
- Uncontrolled hypertension
- Iris trauma
- Patient unwillingness to continue participation in the study
- Occurrence of unwanted systemic complications during the study
- Incorrect medication adherence during the study
- Diabetes
- Hypertension
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Aktiv komparator: Group 1: Tamsulosin
Tamsulosin 0.4 mg, daily.
|
Tamsulosin 0.4 mg, daily.
|
|
Aktiv komparator: Group 2: Silodosin
Silodosin 8 mg, daily.
|
Silodosin 8 mg, daily.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Changes in the dilator muscle region (DMR)
Tidsramme: From baseline to the third month.
|
To determine changes in the DMR under scotopic, mesopic, photopic, and post-dilation conditions.
|
From baseline to the third month.
|
|
Changes in the sphincter muscle region (SMR)
Tidsramme: From baseline to the third month
|
To determine changes in the SMR under scotopic, mesopic, photopic, and post-dilation conditions.
|
From baseline to the third month
|
|
Changes in the DMR/SMR ratio
Tidsramme: From baseline to the third month
|
To determine changes in the DMR/SMR ratio under scotopic, mesopic, photopic, and post-dilation conditions.
|
From baseline to the third month
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Studieleder: Mohsen Pourazizi, Isfahan University of Medical Sciences, Feiz Hospital, Isfahan Isfahan, Isfahan, Iran
Studierekorddatoer
Studer hoveddatoer
Studiestart (Antatt)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Urogenitale sykdommer
- Kjønnssykdommer
- Kjønnssykdommer, mannlige
- Prostata sykdommer
- Mannlige urogenitale sykdommer
- Øyesykdommer
- Uveal sykdommer
- Prostatahyperplasi
- Iris sykdommer
- Svovelforbindelser
- Organiske kjemikalier
- Hydrokarboner
- Hydrokarboner, syklisk
- Hydrokarboner, aromatisk
- Amides
- Benzenderivater
- Benzenesulfonamider
- Sulfonamider
- Sulfoner
- Tamsulosin
- silodosin
Andre studie-ID-numre
- IR.ARI.MUI.REC.1405.118
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