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Cesarean Anesthesia Blood Gas

6. oktober 2026 oppdatert av: ali kahvecioğlu, Bagcilar Training and Research Hospital

Effects of Spinal and General Anesthesia Techniques on Maternal-Fetal Blood Gas Gradients and Fetal Carboxyhemoglobin Levels in Cesarean Delivery: A Prospective Observational Cohort Study

This prospective observational cohort study will evaluate maternal and fetal blood gas parameters in women undergoing cesarean delivery under spinal or general anesthesia. Maternal venous blood samples will be obtained immediately before anesthesia induction, and umbilical arterial blood samples will be obtained after delivery and cord clamping. Blood gas parameters, including pH, pCO2, pO2, bicarbonate, base excess, lactate, and fetal carboxyhemoglobin levels, will be compared between the spinal and general anesthesia groups. The study will also evaluate maternal-fetal blood gas gradients, Apgar scores, neonatal intensive care requirements, and the relationship between smoking exposure and fetal carboxyhemoglobin levels.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Studietype

Observasjonsmessig

Registrering (Antatt)

134

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Tyrkia (Türkiye)
    • Istanbul
      • Istanbul, Istanbul, Tyrkia (Türkiye), 59050
        • Rekruttering
        • Bağcılar Training and Research Hospital
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Hunn

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Pregnant women undergoing cesarean delivery at the Obstetrics and Gynecology Clinic of Bagcilar Training and Research Hospital. The study is a prospective observational cohort comparing maternal and fetal blood gas parameters and fetal carboxyhemoglobin levels according to the observed anesthesia technique (spinal or general anesthesia).

Beskrivelse

Inclusion Criteria:

  • Adult women undergoing cesarean delivery at the study center.
  • Patients receiving spinal or general anesthesia for cesarean delivery.

Exclusion Criteria:

  • Patients who are not eligible for participation according to the study protocol.
  • Patients in whom spinal anesthesia is converted to general anesthesia because of inadequate spinal block and pain during surgery.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Observasjonsmodeller: COHORT
  • Tidsperspektiver: PROSPECTIVE

Kohorter og intervensjoner

Gruppe / Kohort
Intervensjon / Behandling
Spinal Anesthesia

Participants undergoing cesarean delivery who receive spinal anesthesia as the anesthesia technique.
Annen: Anesthesia Technique

Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study.
General Anesthesia

Participants undergoing cesarean delivery who receive general anesthesia as the anesthesia technique.
Annen: Anesthesia Technique

Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Umbilical artery pH
Tidsramme: Immediately after delivery

Umbilical arterial pH measured after delivery and cord clamping.
Immediately after delivery

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Maternal venous pH
Tidsramme: Immediately before anesthesia induction

Maternal venous pH measured immediately before anesthesia induction.
Immediately before anesthesia induction
Umbilical artery pCO2
Tidsramme: Immediately after delivery

Umbilical arterial pCO2 measured after delivery and cord clamping.
Immediately after delivery
Umbilical artery pO2
Tidsramme: Immediately after delivery

Umbilical arterial pO2 measured after delivery and cord clamping.
Immediately after delivery
Maternal venous pCO2
Tidsramme: Immediately before anesthesia induction

Maternal venous pCO2 measured immediately before anesthesia induction
Immediately before anesthesia induction
Maternal venous pO2
Tidsramme: Immediately before anesthesia induction

Maternal venous pO2 measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery HCO3
Tidsramme: Immediately after delivery

Umbilical arterial bicarbonate measured after delivery and cord clamping.
Immediately after delivery
Maternal venous HCO3
Tidsramme: Immediately before anesthesia induction

Maternal venous bicarbonate measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery BE
Tidsramme: Immediately after delivery

Umbilical arterial base excess measured after delivery and cord clamping
Immediately after delivery
Maternal venous BE
Tidsramme: Immediately before anesthesia induction

Maternal venous base excess measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery lactate
Tidsramme: Immediately after delivery

Umbilical arterial lactate measured after delivery and cord clamping
Immediately after delivery
Maternal venous lactate
Tidsramme: Immediately before anesthesia induction

Maternal venous lactate measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery FCOHb
Tidsramme: Immediately after delivery

Fetal carboxyhemoglobin measured in umbilical arterial blood after delivery and cord clamping
Immediately after delivery
Maternal venous FCOHb
Tidsramme: Immediately before anesthesia induction

Maternal carboxyhemoglobin measured in venous blood immediately before anesthesia induction
Immediately before anesthesia induction
Maternal-fetal pH gradient (ΔpH)
Tidsramme: Immediately after delivery

Difference between maternal venous pH and umbilical arterial pH
Immediately after delivery
Maternal-fetal pCO2 gradient (ΔpCO2)
Tidsramme: Immediately after delivery

Difference between maternal venous pCO2 and umbilical arterial pCO2
Immediately after delivery
Maternal-fetal lactate gradient (Δlactate)
Tidsramme: Immediately after delivery

Difference between maternal venous lactate and umbilical arterial lactate
Immediately after delivery
Apgar score at 1 minute
Tidsramme: 1 minute after birth

Apgar score assessed 1 minute after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition.
1 minute after birth
Apgar score at 5 minutes
Tidsramme: 5 minutes after birth

Apgar score assessed 5 minutes after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition.
5 minutes after birth
Neonatal intensive care unit admission
Tidsramme: During the immediate neonatal period

Requirement for admission to the neonatal intensive care unit after birth
During the immediate neonatal period
Neonatal intubation
Tidsramme: During the immediate neonatal period

Requirement for endotracheal intubation after birth
During the immediate neonatal period
Maternal hypotension requiring treatment
Tidsramme: From anesthesia induction until the end of surgery

Occurrence of maternal hypotension requiring pharmacologic treatment during cesarean delivery
From anesthesia induction until the end of surgery
Maternal vasopressor requirement
Tidsramme: From anesthesia induction until the end of surgery

Requirement for vasopressor administration for management of maternal hypotension during cesarean delivery
From anesthesia induction until the end of surgery
Smoking exposure and fetal FCOHb
Tidsramme: Immediately after delivery

Association between maternal smoking exposure status and fetal carboxyhemoglobin level measured in umbilical arterial blood
Immediately after delivery

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Bagcilar Training and Research Hospital

Etterforskere

  • Hovedetterforsker: Ali KAHVECİOĞLU, MD, University of Health Sciences, Bağcılar Training and Research Hospital

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. oktober 2026

Primær fullføring (Antatt)

31. desember 2026

Studiet fullført (Antatt)

31. desember 2026

Datoer for studieregistrering

Først innsendt

28. september 2026

Først innsendt som oppfylte QC-kriteriene

1. oktober 2026

Først lagt ut (Faktiske)

6. oktober 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

8. oktober 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

6. oktober 2026

Sist bekreftet

1. oktober 2026

Mer informasjon

Begreper knyttet til denne studien

Andre studie-ID-numre

  • E-10840098-50.04-4657

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

NEI

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Nei

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Nei

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