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Cesarean Anesthesia Blood Gas

6 oktober 2026 bijgewerkt door: ali kahvecioğlu, Bagcilar Training and Research Hospital

Effects of Spinal and General Anesthesia Techniques on Maternal-Fetal Blood Gas Gradients and Fetal Carboxyhemoglobin Levels in Cesarean Delivery: A Prospective Observational Cohort Study

This prospective observational cohort study will evaluate maternal and fetal blood gas parameters in women undergoing cesarean delivery under spinal or general anesthesia. Maternal venous blood samples will be obtained immediately before anesthesia induction, and umbilical arterial blood samples will be obtained after delivery and cord clamping. Blood gas parameters, including pH, pCO2, pO2, bicarbonate, base excess, lactate, and fetal carboxyhemoglobin levels, will be compared between the spinal and general anesthesia groups. The study will also evaluate maternal-fetal blood gas gradients, Apgar scores, neonatal intensive care requirements, and the relationship between smoking exposure and fetal carboxyhemoglobin levels.

Studie Overzicht

Toestand

Werving

Conditie

Interventie / Behandeling

Studietype

Observationeel

Inschrijving (Geschat)

134

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studiecontact

Studie Locaties

  • Turkije (Türkiye)
    • Istanbul
      • Istanbul, Istanbul, Turkije (Türkiye), 59050
        • Werving
        • Bağcılar Training and Research Hospital
        • Contact:

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

18 jaar en ouder (Volwassen, Oudere volwassene)

Accepteert gezonde vrijwilligers

Nee

Geslachten die in aanmerking komen voor studie

Vrouw

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

Pregnant women undergoing cesarean delivery at the Obstetrics and Gynecology Clinic of Bagcilar Training and Research Hospital. The study is a prospective observational cohort comparing maternal and fetal blood gas parameters and fetal carboxyhemoglobin levels according to the observed anesthesia technique (spinal or general anesthesia).

Beschrijving

Inclusion Criteria:

  • Adult women undergoing cesarean delivery at the study center.
  • Patients receiving spinal or general anesthesia for cesarean delivery.

Exclusion Criteria:

  • Patients who are not eligible for participation according to the study protocol.
  • Patients in whom spinal anesthesia is converted to general anesthesia because of inadequate spinal block and pain during surgery.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Observatiemodellen: COHORT
  • Tijdsperspectieven: PROSPECTIVE

Cohorten en interventies

Groep / Cohort
Interventie / Behandeling
Spinal Anesthesia

Participants undergoing cesarean delivery who receive spinal anesthesia as the anesthesia technique.
Ander: Anesthesia Technique

Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study.
General Anesthesia

Participants undergoing cesarean delivery who receive general anesthesia as the anesthesia technique.
Ander: Anesthesia Technique

Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Umbilical artery pH
Tijdsspanne: Immediately after delivery

Umbilical arterial pH measured after delivery and cord clamping.
Immediately after delivery

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Maternal venous pH
Tijdsspanne: Immediately before anesthesia induction

Maternal venous pH measured immediately before anesthesia induction.
Immediately before anesthesia induction
Umbilical artery pCO2
Tijdsspanne: Immediately after delivery

Umbilical arterial pCO2 measured after delivery and cord clamping.
Immediately after delivery
Umbilical artery pO2
Tijdsspanne: Immediately after delivery

Umbilical arterial pO2 measured after delivery and cord clamping.
Immediately after delivery
Maternal venous pCO2
Tijdsspanne: Immediately before anesthesia induction

Maternal venous pCO2 measured immediately before anesthesia induction
Immediately before anesthesia induction
Maternal venous pO2
Tijdsspanne: Immediately before anesthesia induction

Maternal venous pO2 measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery HCO3
Tijdsspanne: Immediately after delivery

Umbilical arterial bicarbonate measured after delivery and cord clamping.
Immediately after delivery
Maternal venous HCO3
Tijdsspanne: Immediately before anesthesia induction

Maternal venous bicarbonate measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery BE
Tijdsspanne: Immediately after delivery

Umbilical arterial base excess measured after delivery and cord clamping
Immediately after delivery
Maternal venous BE
Tijdsspanne: Immediately before anesthesia induction

Maternal venous base excess measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery lactate
Tijdsspanne: Immediately after delivery

Umbilical arterial lactate measured after delivery and cord clamping
Immediately after delivery
Maternal venous lactate
Tijdsspanne: Immediately before anesthesia induction

Maternal venous lactate measured immediately before anesthesia induction
Immediately before anesthesia induction
Umbilical artery FCOHb
Tijdsspanne: Immediately after delivery

Fetal carboxyhemoglobin measured in umbilical arterial blood after delivery and cord clamping
Immediately after delivery
Maternal venous FCOHb
Tijdsspanne: Immediately before anesthesia induction

Maternal carboxyhemoglobin measured in venous blood immediately before anesthesia induction
Immediately before anesthesia induction
Maternal-fetal pH gradient (ΔpH)
Tijdsspanne: Immediately after delivery

Difference between maternal venous pH and umbilical arterial pH
Immediately after delivery
Maternal-fetal pCO2 gradient (ΔpCO2)
Tijdsspanne: Immediately after delivery

Difference between maternal venous pCO2 and umbilical arterial pCO2
Immediately after delivery
Maternal-fetal lactate gradient (Δlactate)
Tijdsspanne: Immediately after delivery

Difference between maternal venous lactate and umbilical arterial lactate
Immediately after delivery
Apgar score at 1 minute
Tijdsspanne: 1 minute after birth

Apgar score assessed 1 minute after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition.
1 minute after birth
Apgar score at 5 minutes
Tijdsspanne: 5 minutes after birth

Apgar score assessed 5 minutes after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition.
5 minutes after birth
Neonatal intensive care unit admission
Tijdsspanne: During the immediate neonatal period

Requirement for admission to the neonatal intensive care unit after birth
During the immediate neonatal period
Neonatal intubation
Tijdsspanne: During the immediate neonatal period

Requirement for endotracheal intubation after birth
During the immediate neonatal period
Maternal hypotension requiring treatment
Tijdsspanne: From anesthesia induction until the end of surgery

Occurrence of maternal hypotension requiring pharmacologic treatment during cesarean delivery
From anesthesia induction until the end of surgery
Maternal vasopressor requirement
Tijdsspanne: From anesthesia induction until the end of surgery

Requirement for vasopressor administration for management of maternal hypotension during cesarean delivery
From anesthesia induction until the end of surgery
Smoking exposure and fetal FCOHb
Tijdsspanne: Immediately after delivery

Association between maternal smoking exposure status and fetal carboxyhemoglobin level measured in umbilical arterial blood
Immediately after delivery

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Bagcilar Training and Research Hospital

Onderzoekers

  • Hoofdonderzoeker: Ali KAHVECİOĞLU, MD, University of Health Sciences, Bağcılar Training and Research Hospital

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

1 oktober 2026

Primaire voltooiing (Geschat)

31 december 2026

Studie voltooiing (Geschat)

31 december 2026

Studieregistratiedata

Eerst ingediend

28 september 2026

Eerst ingediend dat voldeed aan de QC-criteria

1 oktober 2026

Eerst geplaatst (Werkelijk)

6 oktober 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

8 oktober 2026

Laatste update ingediend die voldeed aan QC-criteria

6 oktober 2026

Laatst geverifieerd

1 oktober 2026

Meer informatie

Termen gerelateerd aan deze studie

Andere studie-ID-nummers

  • E-10840098-50.04-4657

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

NEE

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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