Cesarean Anesthesia Blood Gas
Effects of Spinal and General Anesthesia Techniques on Maternal-Fetal Blood Gas Gradients and Fetal Carboxyhemoglobin Levels in Cesarean Delivery: A Prospective Observational Cohort Study
This prospective observational cohort study will evaluate maternal and fetal blood gas parameters in women undergoing cesarean delivery under spinal or general anesthesia. Maternal venous blood samples will be obtained immediately before anesthesia induction, and umbilical arterial blood samples will be obtained after delivery and cord clamping. Blood gas parameters, including pH, pCO2, pO2, bicarbonate, base excess, lactate, and fetal carboxyhemoglobin levels, will be compared between the spinal and general anesthesia groups. The study will also evaluate maternal-fetal blood gas gradients, Apgar scores, neonatal intensive care requirements, and the relationship between smoking exposure and fetal carboxyhemoglobin levels.
Przegląd badań
Status
Warunki
Interwencja / Leczenie
Typ studiów
Zapisy (Szacowany)
Kontakty i lokalizacje
Kontakt w sprawie studiów
- Nazwa: Ali KAHVECİOĞLU, MD
- Numer telefonu: +90 5549134317
- E-mail: ali.kahveci92@gmail.com
Lokalizacje studiów
-
-
Istanbul
-
Istanbul, Istanbul, Turcja (Türkiye), 59050
- Rekrutacyjny
- Bağcılar Training and Research Hospital
-
Kontakt:
- Ali KAHVECİOĞLU, MD
- Numer telefonu: +90 5549134317
- E-mail: ali.kahveci92@gmail.com
-
-
Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Metoda próbkowania
Badana populacja
Pregnant women undergoing cesarean delivery at the Obstetrics and Gynecology Clinic of Bagcilar Training and Research Hospital. The study is a prospective observational cohort comparing maternal and fetal blood gas parameters and fetal carboxyhemoglobin levels according to the observed anesthesia technique (spinal or general anesthesia).
Opis
Inclusion Criteria:
- Adult women undergoing cesarean delivery at the study center.
- Patients receiving spinal or general anesthesia for cesarean delivery.
Exclusion Criteria:
- Patients who are not eligible for participation according to the study protocol.
- Patients in whom spinal anesthesia is converted to general anesthesia because of inadequate spinal block and pain during surgery.
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
- Modele obserwacyjne: COHORT
- Perspektywy czasowe: PROSPECTIVE
Kohorty i interwencje
Grupa / Kohorta |
Interwencja / Leczenie |
|---|---|
|
Spinal Anesthesia
Participants undergoing cesarean delivery who receive spinal anesthesia as the anesthesia technique. |
Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study. |
|
General Anesthesia
Participants undergoing cesarean delivery who receive general anesthesia as the anesthesia technique. |
Observed anesthesia technique in women undergoing cesarean delivery. Participants received either spinal anesthesia or general anesthesia as part of routine clinical care; the anesthesia technique was not assigned by the study. |
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Umbilical artery pH
Ramy czasowe: Immediately after delivery
|
Umbilical arterial pH measured after delivery and cord clamping. |
Immediately after delivery
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Maternal venous pH
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous pH measured immediately before anesthesia induction. |
Immediately before anesthesia induction
|
|
Umbilical artery pCO2
Ramy czasowe: Immediately after delivery
|
Umbilical arterial pCO2 measured after delivery and cord clamping. |
Immediately after delivery
|
|
Umbilical artery pO2
Ramy czasowe: Immediately after delivery
|
Umbilical arterial pO2 measured after delivery and cord clamping. |
Immediately after delivery
|
|
Maternal venous pCO2
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous pCO2 measured immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Maternal venous pO2
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous pO2 measured immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Umbilical artery HCO3
Ramy czasowe: Immediately after delivery
|
Umbilical arterial bicarbonate measured after delivery and cord clamping. |
Immediately after delivery
|
|
Maternal venous HCO3
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous bicarbonate measured immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Umbilical artery BE
Ramy czasowe: Immediately after delivery
|
Umbilical arterial base excess measured after delivery and cord clamping |
Immediately after delivery
|
|
Maternal venous BE
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous base excess measured immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Umbilical artery lactate
Ramy czasowe: Immediately after delivery
|
Umbilical arterial lactate measured after delivery and cord clamping |
Immediately after delivery
|
|
Maternal venous lactate
Ramy czasowe: Immediately before anesthesia induction
|
Maternal venous lactate measured immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Umbilical artery FCOHb
Ramy czasowe: Immediately after delivery
|
Fetal carboxyhemoglobin measured in umbilical arterial blood after delivery and cord clamping |
Immediately after delivery
|
|
Maternal venous FCOHb
Ramy czasowe: Immediately before anesthesia induction
|
Maternal carboxyhemoglobin measured in venous blood immediately before anesthesia induction |
Immediately before anesthesia induction
|
|
Maternal-fetal pH gradient (ΔpH)
Ramy czasowe: Immediately after delivery
|
Difference between maternal venous pH and umbilical arterial pH |
Immediately after delivery
|
|
Maternal-fetal pCO2 gradient (ΔpCO2)
Ramy czasowe: Immediately after delivery
|
Difference between maternal venous pCO2 and umbilical arterial pCO2 |
Immediately after delivery
|
|
Maternal-fetal lactate gradient (Δlactate)
Ramy czasowe: Immediately after delivery
|
Difference between maternal venous lactate and umbilical arterial lactate |
Immediately after delivery
|
|
Apgar score at 1 minute
Ramy czasowe: 1 minute after birth
|
Apgar score assessed 1 minute after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition. |
1 minute after birth
|
|
Apgar score at 5 minutes
Ramy czasowe: 5 minutes after birth
|
Apgar score assessed 5 minutes after birth using the Apgar score (range, 0-10), with higher scores indicating better neonatal condition. |
5 minutes after birth
|
|
Neonatal intensive care unit admission
Ramy czasowe: During the immediate neonatal period
|
Requirement for admission to the neonatal intensive care unit after birth |
During the immediate neonatal period
|
|
Neonatal intubation
Ramy czasowe: During the immediate neonatal period
|
Requirement for endotracheal intubation after birth |
During the immediate neonatal period
|
|
Maternal hypotension requiring treatment
Ramy czasowe: From anesthesia induction until the end of surgery
|
Occurrence of maternal hypotension requiring pharmacologic treatment during cesarean delivery |
From anesthesia induction until the end of surgery
|
|
Maternal vasopressor requirement
Ramy czasowe: From anesthesia induction until the end of surgery
|
Requirement for vasopressor administration for management of maternal hypotension during cesarean delivery |
From anesthesia induction until the end of surgery
|
|
Smoking exposure and fetal FCOHb
Ramy czasowe: Immediately after delivery
|
Association between maternal smoking exposure status and fetal carboxyhemoglobin level measured in umbilical arterial blood |
Immediately after delivery
|
Współpracownicy i badacze
Śledczy
- Główny śledczy: Ali KAHVECİOĞLU, MD, University of Health Sciences, Bağcılar Training and Research Hospital
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
Zakończenie podstawowe (Szacowany)
Ukończenie studiów (Szacowany)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Rzeczywisty)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Inne numery identyfikacyjne badania
- E-10840098-50.04-4657
Plan dla danych uczestnika indywidualnego (IPD)
Planujesz udostępniać dane poszczególnych uczestników (IPD)?
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Bada produkt urządzenia regulowany przez amerykańską FDA
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