Calorimetry, Insulin Resistance and Energy Metabolism Study to Understand the Risk of Obesity in Kidney Transplanted Patients (CALIMERO)

Inclusion Criteria:

• Male patient, affiliated to a social security system
• Aged 35 to 65 years
• Renal transplant for more than a year and less than 6 years
• Treated by anticalcineurin
• Patient stopped all treatment with corticosteroids for more than 3 months
• Patient with stable renal function defined by a calculated creatinine clearance between 30 and 90 mL/min/1, 73m according to the Cockcroft and Gault
• Written informed consent after detailed explanation of the protocol.
• Increase in body weight of at least 3kg during the two years prior to the inclusion of 10 patients. Stable or increasing weight less than 1kg for 10 other patients.
• HIV and HCV serology negative

Exclusion Criteria:

• Female patients
• Diabetic (type 1 or type 2) before transplantation or patients who developed diabetes after transplantation and requiring anti-diabetic treatment at the time of inclusion
• Obese patient at the time of transplantation, as defined by a body mass index> 30%
• Multiple kidney transplant or other organ transplant the kidney
• Patient with lower limb edema, congestive heart failure, and/or uncontrolled hypertension.
• Patient with a change in body weight> 3 kg in the last 3 months
• Patient with an infection 3 months before inclusion
• Subjects infected with hepatitis B, hepatitis C virus or human immunodeficiency
• Patient with acute rejection within 3 months prior to inclusion
• Patient not treated by anticalcineurin
• Patient with a modification of immunosuppressive therapy within 3 months prior to inclusion
• Patient with unstable psychiatric condition
• Patient smoking> 5 cigarettes / day
• Alcoholic patient (unweaned)
• Patient with stage 4 renal failure (<30 mL/min/1, 73m ²) and stage 5 (<15 mL/min/1, 73m ²)
• hemodialysis patient
• Patient with acute renal failure defined by a 25% increase in creatinine within 3 months prior to inclusion
• Person under guardianship or not subject to social security
• Person in period Exclusion File National Healthy Volunteers
• Person who refuses to give his written consent to participation