EGFR Targeted Photoimmunotherapy With ASP-1929 for Locally Advanced Pancreatic Cancer

Inclusion Criteria:

1. Pathologically confirmed pancreatic adenocarcinoma.
2. Clinically staged locally advanced or borderline resectable pancreatic adenocarcinoma.
3. Completed neoadjuvant chemotherapy
4. Neoadjuvant radiation is allowed
5. Planned surgical exploration
6. Treatment with ASP-1929 will be at least 4 - 10 weeks after last chemotherapy and radiation.
7. Patients with a history of biliary obstruction must have adequate biliary drainage.

8. Patients meeting the following laboratory criteria for Adequate Organ and Bone Marrow Function:

   Platelet Count ≥ 75,000/mm3. Hemoglobin ≥ 8.0 g/dL [NOTE: Participants requiring ongoing transfusions or growth factor support to maintain hemoglobin ≥8.0 g/dL are not eligible] Absolute neutrophil count ≥ 1,000/mm3. [Granulocyte-colony stimulating factor administration is not allowed within 1 week prior to C1D1] Alanine aminotransferase (ALT) ≤ 3×ULN Aspartate aminotransferase (AST) ≤ 3×ULN Total Bilirubin ≤ 1.5×ULN or < 3×ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) Creatinine ≤ 3×ULN

9. Age ≥ 18
10. ECOG performance status 0-1
11. For women of pregnancy potential, a negative pregnancy test within 7 days prior to registration.
12. Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

1. Patients with distant metastases.
2. Patients with medical co-morbidities that make them not candidates for surgical exploration
3. Planned concomitant, non-protocol directed anti-cancer therapy for at least 8 weeks after ASP-1929
4. Patients with unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved to Grade ≤ 1 or baseline. Note: Subjects may be enrolled with chronic, stable Grade 2.
5. History of significant (Grade ≥ 3) cetuximab infusion reactions
6. Photosensitizing medications must be discontinued 4 weeks before ASP-1929 PIT treatment, unless medically required.
7. No uncontrolled intercurrent illness including but not limited to symptomatic CHF, unstable angina, clinically significant severe cardiac arrhythmia, psychiatric illness or social situations that would limit compliance with study requirements.
8. Any other condition which, in the investigator's opinion, deems the patient an unsuitable candidate to receive ASP-1929 and/or be exposed to PIT illumination.
9. Women who are pregnant or nursing.
10. Patients with concomitant malignancies not expected to cause death within 5 years are eligible.