Application of the Stem Cell Therapy in the End Stage Liver Disease and Assessment Its Consequences in the Quality of Live Style as Well as Development of HCC.

Inclusion Criteria:

• Male or female patients aged from 20 to 65 years of age.
• Evidence of chronic liver insufficiency.
• The presence of decreased serum albumin and/or increased bilirubin and/or increased international normalized ratio (INR).
• Patient is unlikely to receive a liver transplant.
• Ability to give written consent
• Women of childbearing potential may be included, but must use a reliable and appropriate contraceptive method

Exclusion Criteria:

• Patients below the age of 20 or above the age of 65 years
• Pregnant or lactating women
• Patients with recent recurrent GI bleeding or spontaneous bacterial peritonitis
• Patients with evidence of HIV or other life threatening infection
• Patients unable to give informed consent
• Patients with a history of hypersensitivity to G-CSF
• Patients who have been included in any other clinical trial within the previous month
• Patient with recurrent attacks of hepatic encephalopathy.
• Evedince of portal vein thrombosis by ultrasound.