Peripheral pULSe Assessment and Arterial pRessure (PULSAR) (PULSAR)
Association Between Palpable Peripheral Pulses and Arterial Blood Pressure in Patients With Circulatory Shock: An International Prospective Multicenter Observational Cohort Study
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure. Peripheral pulse palpation is routinely used in emergency medicine, trauma care, critical care, and cardiopulmonary resuscitation as a rapid clinical assessment of circulation. However, the association between palpable pulses and actual arterial blood pressure remains poorly validated.
Patients treated in emergency departments, intensive care units, operating rooms, and other acute care settings will undergo routine pulse palpation at predefined anatomical locations including carotid, femoral, and radial arteries. Simultaneously measured non-invasive and/or invasive arterial blood pressure values will be recorded from routine clinical monitoring systems. Additional clinical variables relevant to circulatory status will also be collected.
The study seeks to define blood pressure thresholds associated with pulse palpability and evaluate the agreement between invasive and non-invasive blood pressure measurements in patients with circulatory shock.
Visão geral do estudo
Status
Intervenção / Tratamento
Descrição detalhada
The presence or absence of palpable peripheral pulses is widely used as a rapid bedside indicator of circulatory status during trauma care, emergency medicine, intensive care, and cardiopulmonary resuscitation. Advanced Trauma Life Support (ATLS) teaching traditionally assumes that palpable pulses at different anatomical sites correspond to specific systolic blood pressure thresholds. However, these assumptions are based on limited evidence from small observational studies.
This international multicenter prospective observational cohort study aims to investigate the relationship between palpable carotid, femoral, and radial pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure.
Patients receiving routine hemodynamic monitoring with non-invasive blood pressure (NIBP) and/or invasive arterial blood pressure (IBP) monitoring will be included. Pulse palpation will be performed during routine clinical care without altering treatment or management.
The primary objective is to determine the association between pulse palpability and measured systolic blood pressure. Secondary objectives include identifying blood pressure thresholds associated with pulse palpability, evaluating agreement between invasive and non-invasive blood pressure measurements, and assessing whether patient factors such as vascular disease or vasoactive medication use influence pulse palpability.
Tipo de estudo
Inscrição (Estimado)
Contactos e Locais
Contato de estudo
- Nome: Mattias Günther, MD PhD
- Número de telefone: 46812361000
- E-mail: mattias.gunther@ki.se
Locais de estudo
-
-
Stockholm County
-
Stockholm, Stockholm County, Suécia, 11883
- Recrutamento
- Region Stockholm, all hospitals
-
Contato:
- Mattias Günther, MD PhD
- Número de telefone: 46812361000
- E-mail: mattias.gunther@ki.se
-
-
Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
- Adulto
- Adulto mais velho
Aceita Voluntários Saudáveis
Método de amostragem
População do estudo
Descrição
Inclusion Criteria:
- Clinical signs of circulatory shock or impending circulatory failure
- Availability of non-invasive and/or invasive arterial blood pressure monitoring
- Pulse palpation possible without interfering with emergency care
Exclusion Criteria:
- Peripheral vascular conditions preventing reliable pulse palpation
- Major extremity amputation affecting assessment sites
- Clinical situations where study procedures interfere with life-saving treatment
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
Coortes e Intervenções
Grupo / Coorte |
Intervenção / Tratamento |
|---|---|
|
Patients With Circulatory Shock
Adult patients with clinical signs of circulatory shock or impending circulatory failure undergoing routine hemodynamic monitoring with non-invasive and/or invasive arterial blood pressure measurement during standard clinical care.
|
Manual palpation of carotid, femoral, and radial pulses performed during routine clinical care in patients with circulatory instability.
Simultaneous arterial blood pressure measurements are recorded from standard monitoring systems.
No study-specific treatment or intervention is administered.
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Association between palpable pulses and systolic arterial blood pressure
Prazo: During episodes of circulatory instability, up to 24 hours after inclusion
|
Relationship between palpable carotid, femoral, and radial pulses and simultaneously measured systolic arterial blood pressure.
|
During episodes of circulatory instability, up to 24 hours after inclusion
|
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Mean arterial pressure associated with pulse palpability
Prazo: During episodes of circulatory instability, up to 24 hours after inclusion
|
Relationship between pulse palpability and mean arterial pressure (MAP).
|
During episodes of circulatory instability, up to 24 hours after inclusion
|
|
Agreement between non-invasive and invasive blood pressure measurements
Prazo: During episodes of circulatory instability, up to 24 hours after inclusion
|
Agreement between oscillometric non-invasive blood pressure and invasive arterial blood pressure measurements.
|
During episodes of circulatory instability, up to 24 hours after inclusion
|
|
Effect of vascular disease and vasoactive medication on pulse palpability
Prazo: During hospital admission, up to 30 days
|
Influence of peripheral vascular disease, atherosclerosis, age, and vasoactive medications on pulse palpability.
|
During hospital admission, up to 30 days
|
Colaboradores e Investigadores
Patrocinador
Publicações e links úteis
Publicações Gerais
- Kim SH, Lilot M, Sidhu KS, Rinehart J, Yu Z, Canales C, Cannesson M. Accuracy and precision of continuous noninvasive arterial pressure monitoring compared with invasive arterial pressure: a systematic review and meta-analysis. Anesthesiology. 2014 May;120(5):1080-97. doi: 10.1097/ALN.0000000000000226.
- Gunther M, Dahlberg M, Rostami A, Azadali A, Arborelius UP, Linder F, Rostami E. Incidence, Demographics, and Outcomes of Penetrating Trauma in Sweden During the Past Decade. Front Neurol. 2021 Nov 15;12:730405. doi: 10.3389/fneur.2021.730405. eCollection 2021.
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Estimado)
Conclusão Primária (Estimado)
Conclusão do estudo (Estimado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- 2026-02475-01
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
Descrição do plano IPD
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .
Ensaios clínicos em Peripheral Pulse Palpation
-
First Affiliated Hospital Xi'an Jiaotong UniversityXijing Hospital; Children's Hospital of Fudan University; Shaanxi Provincial People... e outros colaboradoresDesconhecidoParalisia cerebral | Lesão Cerebral, CrônicaChina
-
[Redacted]RetidoDoença arterial periférica | Doença Arterial Oclusiva Periférica | ALMOFADA | DAP - Doença Arterial Periférica | Oclusões Totais Crônicas | Oclusão da Artéria
-
ID3 MedicalAtivo, não recrutandoDoença arterial periféricaBélgica, França
-
Avantec VascularBright Research Partners; Yale Cardiovascular Research GroupRecrutamentoDoença arterial periféricaEstados Unidos
-
Marc Bosiers, MDConcluídoAneurisma da Aorta Toracoabdominal, Sem Menção de Ruptura | Aneurisma da Aorta Abdominal, Sem Menção de RupturaAlemanha
-
a2 Milk Company Ltd.Xinhua Hospital, Shanghai Jiao Tong University School of MedicineConcluídoInfecção respiratória | Doença DiarreicaChina
-
Edgard Costa de VilhenaAmparo Maternal Maternidade SocialConcluídoExcesso de peso | Gravidez | Distúrbio mentalBrasil
-
Charite University, Berlin, GermanyCompany HeVaTechConcluído
-
Massachusetts Eye and Ear InfirmaryNational Eye Institute (NEI)Ativo, não recrutandoHemianopsia homônimaEstados Unidos
-
B. Braun Medical Inc.RescindidoComplicações associadas ao dispositivoEstados Unidos