Study of Camtobell Inj (Belotecan) on Weekly Schedule in Non-small Cell Lung Cancer (NSCLC) Patients Previously Treated With Chemotherapy

Inclusion Criteria:

• 19 Years and older
• Histologically or cytologically confirmed locally advanced or metastatic NSCLC(Stage IIIB or IV)
• ≥ one measureable or evaluable lesion, <25% of the bone marrow had been irradiated
• prior platinum based chemotherapy
• ECOG PS ≤ 2
• Life expectancy > 3 months

• Adequate organ function:

  • hematology: ANC ≥ 1.5×109/L, Platelet ≥ 100×109/L, hemoglobin ≥ 9.0g/dL
  • hepatic: total bilirubin ≤ 1.5×ULN, AST/ALT ≤ 2.0×ULN, ALP ≤2.0×ULN
  • renal: serum creatinine ≤ 1.5×ULN
• Signed a written informed consent

Exclusion Criteria:

• Active infection
• Symptomatic brain lesion
• Any other type of cancer during the previous 5 years except appropriately treated basal cell carcinoma of the skin or in situ carcinoma of the cervix
• Severe concurrent diseases
• Prior anticancer therapy within 4 weeks before enroll
• Active pregnancy test