Oxidative Stress on Muscle Dysfunction in Hemodialysis Patient (POPEYE)

Inclusion Criteria:

• Age between 40-80 years old
• less than 150min by week of moderate to vigorous physical activity
• Chronic renal failure (glomerular filtration rate less than 15mL by min) requiring hemodialysis
• Patient placed on the kidney transplant waiting list of MontpellierCHU
• No indication against temporary kidney transplant
• Review cardiovascular older than two years
• Patient not under guardianship or trusteeship
• Clinically stable state Absence or recent infection within 3 months prior to inclusion Absence of progressive neoplasia No recent acute decompensation of chronic disease (thrust of heart failure, respiratory decompensated cirrhosis).

Absence of recent stroke

• musculoskeletal and neurological states of the lower limbs which allow the realization of the proposed functional tests.
• Patient has given written informed consent
• Absence of congenital or genetic degenerative muscle disease

Exclusion Criteria:

• Terminal chronic renal failure without replacement therapy
• Local anesthesic hypersensibility
• Corticosteroid treatment upper than 3 month
• COPD
• Oral anticoagulants
• Previous renal transplantation
• Subject not affiliated with a social security scheme, beneficiary or not such a plan
• Major subject protected by law or unable to consent under Article L 1121-8 of the Public Health Code
• Vulnerable person under Article L.1121-6 of the Public Health Code