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Replication: Meaning-centered Intervention for Internalizing Symptoms

11 augusti 2026 uppdaterad av: University of Groningen

Testing the Efficacy of a Meaning-centered Intervention for Individuals Who Tend to Feel Down or Anxious: a Replication

Young adults who experience depression and/or anxiety symptoms (i.e., internalizing symptoms) will be randomly allocated to a six-session meaning-centered intervention condition or a waitlist condition. Both conditions receive the same questionnaires at baseline, post assessment (intervention condition: immediately after the final session; waitlist: four weeks after baseline), and follow-up.

The researchers hypothesize that a meaning-centered intervention for individuals with internalizing symptoms will increase participants' meaning in life and reduce their internalizing symptoms at post assessment and 4-week follow-up when compared to a waitlist condition.

Studieöversikt

Detaljerad beskrivning

First-year psychology students at the University of Groningen will be screened for depression and anxiety symptoms. Those with heightened symptoms will be invited via e-mail to participate in the study. After filling out the baseline assessment online, participants will be randomly assigned to either a meaning-centered intervention condition, which will receive a meaning-centered intervention taking place approximately every four days, or a waitlist condition, which will be assigned no task. Participants in the intervention condition will follow six 1-hour online intervention sessions led by a trainer and conduct intervention-related homework assignments. The sessions can be followed in English, Dutch, or German. The intervention aims to increase participants' meaning in life and reduce their internalizing symptoms. Immediately after the final session (i.e. approximately one month after the baseline assessment), participants in the intervention condition will be asked to fill in the post assessment, which includes the same questionnaires as the baseline assessment. Additionally, they will be ask to provide feedback about the intervention regarding session and homework content. Participants in the waitlist control will be asked to complete the post assessment one month after their baseline assessment. One month after the post assessment, participants in both conditions are asked to fill in same set of questionnaires. Waitlist participants are offered to receive the intervention sessions after the study has finished. Participants are compensated with SONA credits. This study will replicate a previous study initially testing the meaning-centered intervention (https://clinicaltrials.gov/study/NCT07058181?aggFilters=status:,phase:&tab=researcher#trial-description).

Studietyp

Interventionell

Inskrivning (Beräknad)

140

Fas

  • Inte tillämpbar

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

  • Vuxen
  • Äldre vuxen

Tar emot friska volontärer

Nej

Beskrivning

Inclusion Criteria:

  • heightened internalizing symptoms (depression and/or anxiety symptoms) as indicated by PHQ-4 score of 2 or above on either the anxiety or depression subscale

Exclusion Criteria:

  • receiving psychotherapeutic treatment for a depressive or anxiety disorder
  • suicidality

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

  • Primärt syfte: Behandling
  • Tilldelning: Randomiserad
  • Interventionsmodell: Parallellt uppdrag
  • Maskning: Ingen (Open Label)

Vapen och interventioner

Deltagargrupp / Arm
Intervention / Behandling
Experimentell: Meaning-centered intervention
  • Participants receive a meaning-centered intervention consisting of six 1-hour online sessions led by a trainer.
  • Interventions: Behavioral: Meaning-centered intervention for individuals who tend to feel down or anxious
  • Six 1-hour individual online sessions, approximately every 4 days
  • Sessions led by a certified trainer based on intervention manual
  • Four sources of meaning will be explored: personal life story, dealing with life's limitations, creating one's own life, and meaningful experiences
  • Participants follow intervention using intervention the workbook
  • Homework assignments designed to deepen participants' experience and reflection on meaning in their daily lives
Andra namn:
  • Meaning-centered intervention for internalizing symptoms adapted from the intervention "Meaning-centered intervention for youth worrying about their weight and shape".
Inget ingripande: Waitlist control
- No task or intervention is assigned to participants in this arm.

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Depression Anxiety Stress Scale (DASS-21)
Tidsram: Time Frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)
self-report questionnaire: DASS-21: sum score (0-63), 4-point Likert scale (0-3), higher scores indicating higher internalizing symptoms)
Time Frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)
Meaning in Life Questionnaire (MLQ); presence of meaning subscale
Tidsram: Time Frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)
self-report questionnaire: MLQ: sum score (5-35), 7-point Likert scale (1-7), higher scores indicating higher presence of life meaning
Time Frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Beräknad)

1 oktober 2026

Primärt slutförande (Beräknad)

1 februari 2028

Avslutad studie (Beräknad)

1 februari 2028

Studieregistreringsdatum

Först inskickad

23 juni 2026

Först inskickad som uppfyllde QC-kriterierna

14 juli 2026

Första postat (Faktisk)

20 juli 2026

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

14 augusti 2026

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

11 augusti 2026

Senast verifierad

1 maj 2026

Mer information

Termer relaterade till denna studie

Plan för individuella deltagardata (IPD)

Planerar du att dela individuella deltagardata (IPD)?

NEJ

Läkemedels- och apparatinformation, studiedokument

Studerar en amerikansk FDA-reglerad läkemedelsprodukt

Nej

Studerar en amerikansk FDA-reglerad produktprodukt

Nej

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