The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis
研究概览
详细说明
In other studies, TNFR:Fc significantly reduced joint pain and swelling in adult patients with rheumatoid arthritis, and the Food and Drug Administration has approved the drug for that use. Because medicines for arthritis often help patients with eye inflammation, this study will examine whether TNFR:Fc can help patients with uveitis.
Patients with uveitis who are not responding well to standard treatment, such as steroids, and patients who have side effects from other medicines used to treat their uveitis or have refused treatment because of possible side effects may be eligible for this study. Candidates will be screened with a medical history, physical examination, and eye examination. The eye exam includes a check of vision and eye pressure, examination of the back of the eye (retina), and front of the eye, including measurements of protein and inflammation. Candidates will also undergo fluorescein angiography-a procedure in which photographs are taken of the retina to see if there is any leakage in the eye's blood vessels. A blood test and joint evaluation will also be done.
Study participants will be given an injection of TNFR:Fc twice a week for up to 12 months and may continue other medicines they may be taking, such as prednisone or methotrexate. They will have follow-up examinations at week two and months one, two, three and four. Those who wish to continue treatment after the fourth month can receive the drug for another eight months and will have follow-up exams at months six, nine and 12, and one month after treatment ends. Each follow-up visit will include a repeat of the screening exams and an evaluation of side effects or discomfort from the medicine.
研究类型
阶段
- 第三阶段
联系人和位置
学习地点
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Maryland
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Bethesda、Maryland、美国、20892
- 招聘中
- National Institutes of Health
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接触：
- Susan H Smith
- 电话号码：391-435-4559
- 邮箱：smithsmith@intra.nei.nih.gov
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首席研究员：
- Janine A Smith, M.D.
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Must meet American College of Rheumatology Criteria for JRA.
Must have active anterior uveitis defined as the presence of inflammatory cells (Grade 1+ or higher) in the anterior chamber of at least one eye or the current use of topical corticosteroids to control exacerbation of disease at a frequency of TID or higher.
Age between 2 and 18 years, inclusive.
Ability to undergo slit lamp biomicroscopy for assessment of anterior chamber cells.
Ability to comply with study requirements.
Be up to date on all recommended childhood immunizations.
Using current arthritis regimen for at least 8 weeks prior to enrollment.
No media opacity that precludes assessment of anterior chamber inflammation.
No periocular injection of corticosteroids within 2 months of baseline, or used a systemic experimental therapy within one month of baseline evaluation.
Not currently receiving disease modifying antirheumatic therapy (DMARD), with the exception of prednisone at a dose no greater than 1.0 mg/kg/day, or methotrexate at a dose no greater than 15 mg/m(2)/week.
No active eye or joint inflammation requiring immediate addition or increase in systemic anti-inflammatory medications.
No females who are pregnant or lactating.
No refusal to use contraception during the study and 6 months after termination of active study therapy, if child-bearing or fathering potential exists.
No use of Latanoprost within two weeks prior to enrollment, or have a current or likely need for Latanoprost during the course of the study.
No hypersensitivity to fluorescein dye.
No active serious infections or history of recurring serious infections.
No evidence of spondyloarthropathy or entheseopathy.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
合作者和调查者
研究记录日期
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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