Behavioral and Physiological Effects of Visual Training
Computer-Based Cognitive Training in Normal Healthy Aging: Pilot Study of Behavioral and Physiological Effects of Visual Sweeps Training Exercise, 2-Arm Model
研究概览
详细说明
Virtually all adults will suffer a decline in their cognitive capacities to some degree. Typically, cognitive decline is characterized by a slow, progressive decline in abilities (frequently in memory, attention, inhibition and speed of processing) relative to younger adults, commonly called normal aging, age-associated memory impairment, age-consistent memory impairment, benign senescent forgetfulness, late-life forgetfulness, ageing-associated cognitive decline, and the preferred term, age-related cognitive decline (ARCD) As virtually all adults experience a reduction in their cognitive abilities with age, ARCD has generally been considered to be a normal, inevitable, and irreversible part of aging; and the extremely severe forms of pathological cognitive decline (e.g., Alzheimer's disease, AD) have dominated therapeutic research in this area. However, ARCD represents an important cause of quality of life decline in almost every older adult, as the impact of forgetfulness and mental slowing increasingly change the abilities of individuals to successfully manage their day-to-day activities. Therapeutic approaches targeting the specific problems of ARCD in normal aging (as opposed to the pathological problems of AD) would unto themselves represent important clinical advances.
This trial investigates the effects of a computer-based visual training exercise built on the principles of positive brain plasticity and designed for use by healthy mature individuals. The program is specifically designed to improve the fidelity of sensory representations in early visual cortex.
研究类型
注册 (预期的)
阶段
- 阶段2
- 阶段1
联系人和位置
学习地点
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California
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San Francisco Bay Area、California、美国、94104
- 招聘中
- Posit Science Corporation
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接触：
- Cate Stasio, BA
- 电话号码：3546 4153943100
- 邮箱：cate.stasio@positscience.com
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接触：
- Daniel Tinker, BS
- 电话号码：3541 415-394-3100
- 邮箱：daniel.tinker@positscience.com
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首席研究员：
- Joseph L Hardy, PhD
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副研究员：
- Daniel Tinker, BS
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Age 60 or older at the time of consent.
- Mini-Mental Status Examination (MMSE) score of 26 or higher.
- Adequate visual capacity adequate to read.
- Adequate hearing capacity.
- Willing and able to commit to study time requirements.
Exclusion Criteria:
- Self-report of current diagnosis or history of major neurological illness.
- Self-report of current diagnosis or history of psychiatric illness. c. History of psychiatric hospitalization in the past twenty years.
- History of a stroke, transient ischemic attack (TIA) or traumatic brain injury within the past year; or lifetime history of stroke, TIA, or traumatic brain injury that has left residual expressive or receptive language problems. - Fibromyalgia or symptoms of severe tremor.
- Self-report of current substance abuse, including alcoholism.
- Current useof medications with substantial CNS effects. Inappropriate behaviors during screening or baseline visits.
- Inability to perform behavioral evaluations.
- Participant is not capable of giving informed consent or unable to comprehend and/or follow instructions.
- Participant is enrolled in a concurrent clinical study that could affect the outcome of this study.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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无干预：I
No contact control (NCC)
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实验性的：II
Computerized, SAAGE-designed, visual memory-based cognitive training
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Training sessions take 40 minutes per day, five days per week for a total goal of 15, 40-minute sessions.
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Improvement in visual memory assessment after training or no-contact period.
大体时间：6-8 weeks
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6-8 weeks
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Improvement on at least 1 of the Computerized Visual Attention, Speed and Memory Tests conducted.
大体时间：6-8 weeks
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6-8 weeks
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Improvement on the computerized cognitive assessments.
大体时间：6-8 weeks
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6-8 weeks
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Improvement on exercise-based assessments.
大体时间：6-8 weeks
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6-8 weeks
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合作者和调查者
调查人员
- 首席研究员：Joseph L Hardy, PhD、Posit Science Corporation
出版物和有用的链接
一般刊物
- Bischkopf J, Busse A, Angermeyer MC. Mild cognitive impairment--a review of prevalence, incidence and outcome according to current approaches. Acta Psychiatr Scand. 2002 Dec;106(6):403-14. doi: 10.1034/j.1600-0447.2002.01417.x.
- Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul;77(7):681-96. doi: 10.4065/77.7.681.
- Ahissar E, Nagarajan S, Ahissar M, Protopapas A, Mahncke H, Merzenich MM. Speech comprehension is correlated with temporal response patterns recorded from auditory cortex. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13367-72. doi: 10.1073/pnas.201400998.
- Park HL, O'Connell JE, Thomson RG. A systematic review of cognitive decline in the general elderly population. Int J Geriatr Psychiatry. 2003 Dec;18(12):1121-34. doi: 10.1002/gps.1023.
- Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep. 2004 Sep;4(5):374-80. doi: 10.1007/s11910-004-0084-7.
研究记录日期
研究主要日期
学习开始
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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