- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00526942
Behavioral and Physiological Effects of Visual Training
Computer-Based Cognitive Training in Normal Healthy Aging: Pilot Study of Behavioral and Physiological Effects of Visual Sweeps Training Exercise, 2-Arm Model
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Virtually all adults will suffer a decline in their cognitive capacities to some degree. Typically, cognitive decline is characterized by a slow, progressive decline in abilities (frequently in memory, attention, inhibition and speed of processing) relative to younger adults, commonly called normal aging, age-associated memory impairment, age-consistent memory impairment, benign senescent forgetfulness, late-life forgetfulness, ageing-associated cognitive decline, and the preferred term, age-related cognitive decline (ARCD) As virtually all adults experience a reduction in their cognitive abilities with age, ARCD has generally been considered to be a normal, inevitable, and irreversible part of aging; and the extremely severe forms of pathological cognitive decline (e.g., Alzheimer's disease, AD) have dominated therapeutic research in this area. However, ARCD represents an important cause of quality of life decline in almost every older adult, as the impact of forgetfulness and mental slowing increasingly change the abilities of individuals to successfully manage their day-to-day activities. Therapeutic approaches targeting the specific problems of ARCD in normal aging (as opposed to the pathological problems of AD) would unto themselves represent important clinical advances.
This trial investigates the effects of a computer-based visual training exercise built on the principles of positive brain plasticity and designed for use by healthy mature individuals. The program is specifically designed to improve the fidelity of sensory representations in early visual cortex.
Undersøgelsestype
Tilmelding (Forventet)
Fase
- Fase 2
- Fase 1
Kontakter og lokationer
Studiekontakt
- Navn: Daniel Tinker, BS
- Telefonnummer: 3541 4153943100
- E-mail: daniel.tinker@positscience.com
Undersøgelse Kontakt Backup
- Navn: Cate Stasio, BA
- Telefonnummer: 3546 4153943100
- E-mail: cate.stasio@positscience.com
Studiesteder
-
-
California
-
San Francisco Bay Area, California, Forenede Stater, 94104
- Rekruttering
- Posit Science Corporation
-
Kontakt:
- Cate Stasio, BA
- Telefonnummer: 3546 4153943100
- E-mail: cate.stasio@positscience.com
-
Kontakt:
- Daniel Tinker, BS
- Telefonnummer: 3541 415-394-3100
- E-mail: daniel.tinker@positscience.com
-
Ledende efterforsker:
- Joseph L Hardy, PhD
-
Underforsker:
- Daniel Tinker, BS
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Age 60 or older at the time of consent.
- Mini-Mental Status Examination (MMSE) score of 26 or higher.
- Adequate visual capacity adequate to read.
- Adequate hearing capacity.
- Willing and able to commit to study time requirements.
Exclusion Criteria:
- Self-report of current diagnosis or history of major neurological illness.
- Self-report of current diagnosis or history of psychiatric illness. c. History of psychiatric hospitalization in the past twenty years.
- History of a stroke, transient ischemic attack (TIA) or traumatic brain injury within the past year; or lifetime history of stroke, TIA, or traumatic brain injury that has left residual expressive or receptive language problems. - Fibromyalgia or symptoms of severe tremor.
- Self-report of current substance abuse, including alcoholism.
- Current useof medications with substantial CNS effects. Inappropriate behaviors during screening or baseline visits.
- Inability to perform behavioral evaluations.
- Participant is not capable of giving informed consent or unable to comprehend and/or follow instructions.
- Participant is enrolled in a concurrent clinical study that could affect the outcome of this study.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Ingen indgriben: I
No contact control (NCC)
|
|
Eksperimentel: II
Computerized, SAAGE-designed, visual memory-based cognitive training
|
Training sessions take 40 minutes per day, five days per week for a total goal of 15, 40-minute sessions.
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Improvement in visual memory assessment after training or no-contact period.
Tidsramme: 6-8 weeks
|
6-8 weeks
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
Improvement on at least 1 of the Computerized Visual Attention, Speed and Memory Tests conducted.
Tidsramme: 6-8 weeks
|
6-8 weeks
|
Improvement on the computerized cognitive assessments.
Tidsramme: 6-8 weeks
|
6-8 weeks
|
Improvement on exercise-based assessments.
Tidsramme: 6-8 weeks
|
6-8 weeks
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Joseph L Hardy, PhD, Posit Science Corporation
Publikationer og nyttige links
Generelle publikationer
- Bischkopf J, Busse A, Angermeyer MC. Mild cognitive impairment--a review of prevalence, incidence and outcome according to current approaches. Acta Psychiatr Scand. 2002 Dec;106(6):403-14. doi: 10.1034/j.1600-0447.2002.01417.x.
- Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul;77(7):681-96. doi: 10.4065/77.7.681.
- Ahissar E, Nagarajan S, Ahissar M, Protopapas A, Mahncke H, Merzenich MM. Speech comprehension is correlated with temporal response patterns recorded from auditory cortex. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13367-72. doi: 10.1073/pnas.201400998.
- Park HL, O'Connell JE, Thomson RG. A systematic review of cognitive decline in the general elderly population. Int J Geriatr Psychiatry. 2003 Dec;18(12):1121-34. doi: 10.1002/gps.1023.
- Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep. 2004 Sep;4(5):374-80. doi: 10.1007/s11910-004-0084-7.
Datoer for undersøgelser
Studer store datoer
Studiestart
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- RES-203-2007
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .