Study of the Development of Human Immune System of Newborns by Antigen Chips
The immune system is a dynamic, constantly evolving network. Excluding autoimmune diseases, healthy individuals are also known to have a large number of circulating antibodies that can recognize proteins of their own tissues. These antibodies are known as natural antibodies and previous studies suggested that some features of these "self" components are shared by individuals in certain physiological states. Thus, monitoring self immunoglobulins can provide an overview of the various states of the immune system. To do so, and in the process to obtain systems biology view of the immune system, the newly developed Antigen Chip technology has been used.
To further investigate this subject we plan to carry out broader investigations that will be conducted in collaboration with the group of Prof. Eshel Ben-Jacob from the university of Tel-Aviv and Prof. Irun Cohen from the Weizmann Institute that have the required experimental and analytical expertise and facilities. The studies will include follow-up on the immune state of babies and their mothers for several months post birth using the Antigen Chip and analyzed by the Immune holography method. The investigations will also include comparative studies between the immune signature of different body fluids, the effects of feeding, and the effect method and time of labor.
研究概览
地位
详细说明
研究类型
注册 (预期的)
联系人和位置
学习地点
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Ramat Gan、以色列、52621
- Sheba Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Term and preterm newborns and their mothers
- Age 1 day to 7 weeks
Exclusion Criteria:
- Maternal immune dieases
- Major congential malformations
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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preterms
mother and preterm babies
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term-bfing
term breastfed babies and mothers
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term-PIF
term non breastfed babies and mothers
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c-section
c-section babies and their mothers
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- SHEBA-08-5441-AM-CTIL
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