Comparison of Two Exercise Interventions to Improve Gait in Older Persons (PRIME)
Comparison of Two Exercise Interventions to Improve Gait in Older Persons: The PRIME (Program to Improve Mobility in The Elderly) Study
研究概览
详细说明
The purpose of this research study is to compare two different exercise treatments for walking problems in older adults. We want to determine if participation in the exercise programs for 3 months will improve walking abilities by improving balance and strength.
Adults aged 65 years or older, who are able to walk without the help of another person, are being asked to participate. If you are able to walk independently and you have medical clearance from your physician to participate in activities requiring low to moderate physical activity, you are invited to participate. We plan to enroll 40 older adults, all who have small problems with walking due to balance or strength, in this research study.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Pennsylvania
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Pittsburgh、Pennsylvania、美国、15260
- University of Pittsburgh
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- 65 years of age and older
- Ambulatory without an assistive device or the assistance of another person
- Usual 4 meter gait speed ≥1.0 m/s
- Completes a figure-of-eight walk in > 8.0 seconds
Exclusion Criteria:
Inability to participate in testing:
- persistent lower extremity pain that is present on most days of the week and crepitus, tenderness or enlargement of joints of the lower extremity (arthritis).84
- back pain that is present on most days of the weeks and interferes with walking and activities of daily living or back pain that increases with walking (lumbar stenosis)
- calf pain or cramping which worsens with walking and is relieved by rest (PAD)
- refusal to walk on a treadmill
Safety concerns:
- dyspnea at rest or during activities of daily living or use supplemental oxygen (CHF, COPD)
- any acute illness or medical condition that is not stable according to the approving physician
- resting systolic blood pressure ≥ 200 mm Hg or diastolic blood pressure ≥ 100 mm Hg or resting heart rate > 100 or < 40 beats per minute85
- diagnosed dementia or cognitive impairment defined as a MMSE score < 24
- hospitalized in the past 6 months for acute illness or surgery, other than minor surgical procedures
- severe visual impairment with visual acuity < 20/70 with best correction
- history of stroke
- fixed or fused lower extremity joints such as hip, knee or ankle
- lower extremity strength <4/5 on manual muscle testing
- lower extremity amputation
- progressive movement disorder such as MS, ALS or Parkinson's disease
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的:skill-based exercise
2 times per week for 12 weeks.
warm-up, stretching, strengthening, and skill-based exercises.
Pre-gait and gait activities including stepping patterns and walking patterns and treadmill training at various walking speeds
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2 times per week for 12 weeks Pre gait and gait activities
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有源比较器:aerobic exercise training
warm-up, strengthening and aerobic conditioning (treadmill walking)
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2 times per week for 12 weeks.
aerobic conditioning exercise consisting of treadmill walking
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Gait
大体时间:12 weeks
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gait characteristics, smoothness of walking, 6 MWT, complex walking tests, GARS-M, SPPB, energy cost, SAFFE, GES, figure of 8
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12 weeks
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Physical function
大体时间:12 weeks
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LLFDI function and disability scales
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12 weeks
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Physical Activity
大体时间:12 weeks
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Actigraph accelerometer
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12 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Disability and health care costs
大体时间:6 months post exercise
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Late Life Function and disability index, fall history and health care cost questionnaire will be administered through a phone interview 6 months following completion of the exercise program
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6 months post exercise
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合作者和调查者
出版物和有用的链接
一般刊物
- Brach JS, Lowry K, Perera S, Hornyak V, Wert D, Studenski SA, VanSwearingen JM. Improving motor control in walking: a randomized clinical trial in older adults with subclinical walking difficulty. Arch Phys Med Rehabil. 2015 Mar;96(3):388-94. doi: 10.1016/j.apmr.2014.10.018. Epub 2014 Nov 10.
- Brach JS, Van Swearingen JM, Perera S, Wert DM, Studenski S. Motor learning versus standard walking exercise in older adults with subclinical gait dysfunction: a randomized clinical trial. J Am Geriatr Soc. 2013 Nov;61(11):1879-86. doi: 10.1111/jgs.12506. Epub 2013 Oct 28.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- PRO09080228
- K23AG026766 (美国 NIH 拨款/合同)
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