Panobinostat Plus Ifosfamide, Carboplatin, and Etoposide (ICE) Compared With ICE For Relapsed Hodgkin Lymphoma
Phase I Study of Panobinostat Plus ICE Chemotherapy Followed by a Randomized Phase-II Study of ICE Compared With Panobinostat Plus ICE for Patients With Relapsed and Refractory Classical Hodgkin Lymphoma
Objectives:
Primary objective:
- Phase-I: To determine the maximal tolerated dose (MTD) of panobinostat (LBH589) + Ifosfamide + Mesna, Carboplatin and Etoposide (ICE) combination
- Randomized Phase-II: To estimate the complete response (CR) rate in patients with relapsed and refractory classical Hodgkins Lymphoma (HL) receiving ICE versus PANOBINOSTAT plus ICE therapy
Secondary Objectives:
- To assess the safety and tolerability of the novel combination of PANOBINOSTAT (LBH589) plus ICE versus ICE in patients with relapsed and refractory HL
- To estimate the overall response rate (CR + partial response PR)
- To estimate the success rate of stem cell collection in patients eligible for stem cell transplant
- To estimate the percentage of patients who subsequently undergo autologous stem cell transplantation (ASCT)
- To estimate the event free survival (EFS) at 1 year after randomization
- To determine pretreatment expression level of histone deacetylases (HDAC1), HDAC2, and pSTAT3 and Signal transducer and activator of transcription protein (pSTAT6) by Immunohistochemistry (IHC) and correlate the results with treatment response
研究概览
地位
条件
详细说明
Phase I:
The Study Drugs:
Panobinostat is designed to block the function of enzymes that are found inside cancer cells. These enzymes trigger cells to grow and multiply out of control. By blocking these enzymes, it may slow down the growth of or kill cancer cells.
Ifosfamide is designed to slow or stop the growth of cancer cells.
Carboplatin is designed to interfere with the growth of cancer cells by stopping cell division, which may cause the cells to die.
Etoposide is designed to block cell growth.
Baseline Tests:
If you are found to be eligible to take part in this study, the following tests and procedures will be performed about 7 days before the first dose of the study drug:
- You will have a physical exam, including measurement of your height, weight, and vital signs (blood pressure and heart rate).
- You will have 1 electrocardiogram (ECG -- a test that measures the electrical activity of the heart).
- Blood (about 2 1/2 teaspoons) will be drawn for routine tests.
- Women who are able to become pregnant must have a negative blood (about 1 1/2 teaspoons) pregnancy test.
Study Groups:
You will be assigned to a dose level of panobinostat based on when you join this study. Up to 2 dose levels of panobinostat will be tested. Up to 6participants will be enrolled at each dose level. The first group of participants will receive the lowest dose level. Each new group will receive a higher dose than the group before it, if no intolerable side effects were seen. This will continue until the highest tolerable dose of panobinostat is found.
All participants will receive the same dose level of ICE.
Once the highest tolerable dose is found, up to 20 extra participants, called the expansion group, will receive the study drugs at that dose.
Study Drug Administration:
Each cycle is 14 days.
ICE Administration:
On Day 1 (+/- 2 days) of Cycles 1-3, you will receive ifosfamide by vein over 24 hours.
On Day 1 (+/- 2 days) of Cycles 1-3, you will receive carboplatin by vein over 1 hour.
On Days 1-3 (+/- 2 days) of Cycles 1-3, you will receive etoposide by vein over 2 hours.
You will also receive mesna to help prevent side effects. On Day 2 (+/- 2 days) of Cycles 1-3, you will receive mesna by vein over 12 hours.
You will also receive pegfilgrastim to help prevent side effects. Beginning 24-48 hours after the completion of chemotherapy of Cycles 1-3, you will take pegfilgrastim through a needle under the skin.
Panobinostat Administration:
You will take panobinostat by mouth starting Day -6 of Cycle 1 (6 days before your first dose of ICE). You will take the panobinostat on Days -6, -4, and -2 of Cycle 1 and Days 1, 3, 5, 8, 10, and 12 of Cycles 1 and 2.
If you are in the expansion group, you will take panobinostat by mouth starting Day -6 of Cycle 1 (6 days before your first dose of ICE). You will take the panobinostat on Days -6, -4, and -2 of Cycle 1 and Days 1, 3, and 5 of Cycles 1 and 2.
You should take panobinostat around the same time each day with 1 cup (8 ounces) of water. You should swallow the capsules whole and not chew them. You must avoid grapefruit or grapefruit juice and seville (sour) oranges while on study.
If you miss a dose of panobinostat, take it as soon as you remember it on the same day. However, if more than 12 hours have passed since you were supposed to take the dose, you should skip that day's dose. In that case, wait to take panobinostat until the next scheduled dosing day.
Study Visits:
On Days -6 and -2 of Cycle 1, you will have 2 ECGs.
Within 7 days before each ICE therapy:
- You will have a physical exam, including measurement of your height, weight, and vital signs.
- Blood (about 2 1/2 teaspoons) will be drawn for routine tests.
- You will be asked if you have had any side effects.
One (1) time a week, blood (2 1/2 teaspoons) will be drawn for routine tests.
On Day 1 of Cycles 2 and beyond, you will have an ECG.
After Cycle 3:
- You will have a CT scan of your head and neck, chest, abdomen, and pelvis to check the status of the disease.
- If your bone marrow was positive at screening, you will have a positron emission tomography (PET) scan to check the status of the disease.
Length of Study:
You be on study for up to 3 cycles (about 42 days). You will be taken off study early if the disease worsens or you experience intolerable side effects.
End-of-Study Visit:
After you are off study, you will have an end-of-study visit at which the following will be performed:
You will have a physical exam, including measurement of your weight and vital signs.
You will have an ECG.
This is an investigational study. Panobinostat is not FDA approved or commercially available. It is currently being used for research purposes only.
ICE is FDA approved and commercially available for the treatment of several types of lymphoma, including relapsed and refractory Hodgkins lymphoma. The combination of panobinostat and ICE for the treatment of Hodgkin's lymphoma is investigational.
Up to 102 patients will take part in this study. All will be enrolled at MD Anderson.
Phase II:
The Study Drugs:
Panobinostat is designed to block the function of enzymes that are found inside cancer cells. These enzymes trigger cells to grow and multiply out of control. By blocking these enzymes, it may slow down the growth of or kill cancer cells.
Ifosfamide is designed to slow or stop the growth of cancer cells.
Carboplatin is designed to interfere with the growth of cancer cells by stopping cell division, which may cause the cells to die.
Etoposide is designed to block cell growth.
Baseline Tests:
If you are found to be eligible to take part in this study, the following tests and procedures will be performed about 7 days before the first dose of the study drug:
- You will have a physical exam, including measurement of your height, weight, and vital signs (blood pressure and heart rate).
- You will have 1 electrocardiogram (ECG -- a test that measures the electrical activity of the heart).
- Blood (about 2 1/2 teaspoons) will be drawn for routine tests.
- Women who are able to become pregnant must have a negative blood (about 1 1/2 teaspoons) pregnancy test.
Study Groups:
You will be randomly assigned (as in the flip of a coin) to 1 of 2 groups.
- If you are in Group 1, you will receive ICE.
- If you are in Group 2, you will receive ICE and panobinostat.
Study Drug Administration:
Each cycle is 14 days.
ICE Administration:
On Day 1 (+/- 2 days) of Cycles 1-3, you will receive ifosfamide by vein over 24 hours.
On Day 1 (+/- 2 days) of Cycles 1-3, you will receive carboplatin by vein over 1 hour.
On Days 1-3 (+/- 2 days) of Cycles 1-3, you will receive etoposide by vein over 2 hours.
You will also receive mesna to help prevent side effects. On Day 2 (+/- 2 days) of Cycles 1-3, you will receive mesna by vein over 12 hours.
You will also receive pegfilgrastim to help prevent side effects. Beginning 24-48 hours after the completion of chemotherapy of Cycles 1-3, you will take pegfilgrastim through a needle under the skin.
Panobinostat Administration:
If you are in a group that will receive panobinostat, you will take panobinostat by mouth starting Day -6 of Cycle 1 (6 days before your first dose of ICE). You will take the panobinostat on 3 times a week during Cycles 1 and 2 (Days -6, -4, and -2 of Cycle 1 and Days 1, 3, and 5 Cycles 1 and 2).
You should take panobinostat around the same time each day with 1 cup (8 ounces) of water. You should swallow the capsules whole and not chew them. You must avoid grapefruit or grapefruit juice and seville (sour) oranges while on study.
If you miss a dose of panobinostat, take it as soon as you remember it on the same day. However, if more than 12 hours have passed since you were supposed to take the dose, you should skip that day's dose. In that case, wait to take panobinostat until the next scheduled dosing day.
Study Visits:
On Days -6 and -2 of Cycle 1, you will have 2 ECGs.
Within 7 days before each ICE therapy:
- You will have a physical exam, including measurement of your height, weight, and vital signs.
- Blood (about 2 1/2 teaspoons) will be drawn for routine tests.
- You will be asked if you have had any side effects.
One (1) time a week, blood (2 1/2 teaspoons) will be drawn for routine tests.
On Day 1 of Cycles 2 and beyond, you will have an ECG.
After Cycle 3:
- You will have a CT scan of your head and neck, chest, abdomen, and pelvis to check the status of the disease.
- If your bone marrow was positive at screening, you will have a PET scan to check the status of the disease.
Length of Study:
You be on study for up to 3 cycles (about 42 days). You will be taken off study early if the disease worsens or you experience intolerable side effects.
End-of-Study Visit:
After you are off study, you will have an end-of-study visit at which the following will be performed:
- You will have a physical exam, including measurement of your weight and vital signs.
- You will have an ECG.
This is an investigational study. Panobinostat is not FDA approved or commercially available. It is currently being used for research purposes only.
ICE is FDA approved and commercially available for the treatment of several types of lymphoma, including relapsed and refractory Hodgkins lymphoma. The combination of panobinostat and ICE for the treatment of Hodgkin's lymphoma is investigational.
Up to 102 patients will take part in this study. All will be enrolled at MD Anderson.
研究类型
注册 (实际的)
阶段
- 阶段2
- 阶段1
联系人和位置
学习地点
-
-
Texas
-
Houston、Texas、美国、77030
- University of Texas MD Anderson Cancer Center
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Histologically confirmed classical Hodgkin lymphoma (nodular sclerosis, mixed cellularity, or lymphocyte-rich classical HL).
- Patients must have failed (relapsed or refractory) front-line standard anthracycline-containing regimen, such as ABVD, Stanford V, or BEACOPP.
- Bidimensionally measurable disease with at least 1 lesion >/= 2.0 cm in a single dimension
- Acceptable hematologic status:Hemoglobin >/= 9.0 g/dL, Absolute neutrophil count >/= 1500 cells/mm3, Platelet count >/= 100,000 cells/mm3
- Normal serum K+, Mg+, PO4, and total Ca++ (pre-treatment abnormal values may be therapeutically corrected before starting therapy and must be documented as normal or if abnormal values persist must be documented as clinically insignificant). Albumin should be >/= 3
- Pre-study World Health Organization (WHO) performance status of 0, 1, or 2
- Age >/= 16 years
- Voluntary signed Institutional Review Board (IRB) approved consent informed before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.
- Patients of reproductive potential (female of child bearing potential has not been postmenopausal for at least 12 consecutive months or not surgically sterile; male of child bearing potential has not been surgically sterile)must follow accepted birth control methods (e.g. barrier method) during treatment.
- Clinically euthyroid. Note: Patients are permitted to receive thyroid hormone supplements to treat underlying hypothyroidism.
- Baseline Multiple Gated Acquisition (MUGA) or ECHO must demonstrate left ventricular ejection fraction (LVEF) >/= 50%.
Exclusion Criteria:
- Lymphocyte predominant histology
- More than one prior chemotherapy regimens.
- Prior therapy with other HDAC inhibitors, including valproic acid
- Prior therapy with heat shock protein (HSP)-90 inhibitors
- Prior stem cell transplant
- Abnormal liver function: Bilirubin > 2.0 mg/dL (26 µmol/L), Alkaline phosphatase > 2 x upper limits of normal (ULN), aspartate aminotransferase AST (SGOT) and/or alanine aminotransferase ALT > 2 x ULN
- Serum creatinine >1.5 mg/dl
- Presence of Central Nervous System (CNS) involvement with Hodgkin lymphoma
- Presence of Human immunodeficiency virus (HIV) infection or acquired immune deficiency syndrome (AIDS).
- Another primary malignancy (other than squamous cell and basal cell carcinoma of the skin, in situ carcinoma of the cervix, or treated prostate cancer with a stable Prostate Specific Antigen PSA) for which the patient has not been disease free for at least 3 years.
- Serious nonmalignant disease (e.g., congestive heart failure, hydronephrosis); active uncontrolled bacterial, viral, or fungal infections; or other conditions which would compromise protocol objectives in the opinion of the investigator
- Impaired cardiac function or clinically significant cardiac diseases, including any one of the following:History or presence of sustained ventricular tachyarrhythmia, Any history of ventricular fibrillation or torsade de pointes, Bradycardia defined as HR< 50 bpm, Patients with pacemakers are eligible if HR >/= 50 bpm, Screening ECG with a corrected QT interval (QTc) > 450 msec, Right bundle branch block + left anterior hemiblock (bifascicular block), Patients with myocardial infarction or unstable angina </= 6 months prior to starting study drug, Other clinically significant heart disease (e.g., congestive heart failure (CHF) New York Heart Association class III or IV , uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen)
- Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum Beta-human chorionic gonadotropin (Beta-hCG) pregnancy test result obtained during screening, unless the female has recently (within 8 weeks) undergone egg harvest, which would result in the (Beta-hCG) test to be elevated without pregnancy. Pregnancy testing is not required for post-menopausal or surgically sterilized women.
- Patient has received other investigational drugs within 14 days before enrollment or who have not recovered from side effects of those therapies.
- Serious medical or psychiatric illness likely to interfere with participation in this clinical study.
- Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of panobinostat
- Patients with diarrhea > Common Terminology Criteria for Adverse Events Version 4 (CTCAE V.4) grade 2
- Patients using medications that have a relative risk of prolonging the QT interval or inducing torsade de pointes if treatment cannot be discontinued or switched to a different medication prior to starting study drug.
- Patients who have received either immunotherapy within </= 8 weeks; chemotherapy within </= 3 weeks; or radiation therapy to > 30% of marrow-bearing bone within </= 2 weeks prior to starting study treatment; or who have not yet recovered from side effects of such therapies.
- Patients who have undergone major surgery </= 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Panobinostat MTD + ICE
Phase 1: Escalating Panobinostat dose with routine ICE Chemotherapy
|
Starting Day -6 of Cycle 1, 20 mg orally on Monday, Wednesday, and Friday during Cycles 1 and 2 (Days -6, -4, and -2 of Cycle 1 and Days 1, 3, 5, 8, 10, and 12 of Cycles 1 and 2); MTD found in Phase 1 used for same schedule in Phase 2.
其他名称：
Day 1 of Cycles 1-3, 5 grams/m2 by vein over 24 hours.
其他名称：
On Day 1 of Cycles 1-3, 2 grams/m2 by vein over 12 hours.
其他名称：
On Day 1 of Cycles 1-3, Standard Dose (Target area under curve (AUC) = 5mg/ml/min) by vein over 1 hour.
其他名称：
On Days 1-3 of Cycles 1-3, 100 mg/m2 by vein over 2 hours.
其他名称：
|
|
实验性的：ICE Chemotherapy
Phase 2: Routine ICE Chemotherapy (Ifosfamide, Carboplatin, + Etoposide)
|
Day 1 of Cycles 1-3, 5 grams/m2 by vein over 24 hours.
其他名称：
On Day 1 of Cycles 1-3, 2 grams/m2 by vein over 12 hours.
其他名称：
On Day 1 of Cycles 1-3, Standard Dose (Target area under curve (AUC) = 5mg/ml/min) by vein over 1 hour.
其他名称：
On Days 1-3 of Cycles 1-3, 100 mg/m2 by vein over 2 hours.
其他名称：
Beginning Day 4 of Cycles 1-3, 6 mg under the skin.
其他名称：
|
|
实验性的：Panobinostat + ICE
Phase 2: Panobinostat with ICE Chemotherapy
|
Starting Day -6 of Cycle 1, 20 mg orally on Monday, Wednesday, and Friday during Cycles 1 and 2 (Days -6, -4, and -2 of Cycle 1 and Days 1, 3, 5, 8, 10, and 12 of Cycles 1 and 2); MTD found in Phase 1 used for same schedule in Phase 2.
其他名称：
Day 1 of Cycles 1-3, 5 grams/m2 by vein over 24 hours.
其他名称：
On Day 1 of Cycles 1-3, 2 grams/m2 by vein over 12 hours.
其他名称：
On Day 1 of Cycles 1-3, Standard Dose (Target area under curve (AUC) = 5mg/ml/min) by vein over 1 hour.
其他名称：
On Days 1-3 of Cycles 1-3, 100 mg/m2 by vein over 2 hours.
其他名称：
Beginning Day 4 of Cycles 1-3, 6 mg under the skin.
其他名称：
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Maximum Tolerated Dose (MTD) of Panobinostat + ICE
大体时间：From first dose of panobinostat (or chemotherapy, in the arm of ICE alone) until 30 days after last dose, up to 6 years
|
Maximum Tolerated Dose (MTD) of Panobinostat + ICE
|
From first dose of panobinostat (or chemotherapy, in the arm of ICE alone) until 30 days after last dose, up to 6 years
|
|
Number of Participants With Complete Remission (CR)
大体时间：Assessed after 3 cycles of ICE (2 months)
|
Will be assessed by Kaplan-Meier methods.
|
Assessed after 3 cycles of ICE (2 months)
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Percentage of Participants With Failure Free Survival (FFS)
大体时间：16 months
|
FFS duration was calculated from date of study entry to date of progression or death or change of therapy, whichever came first.
|
16 months
|
合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- 2010-0065
- NCI-2012-01779 (注册表标识符：NCI CTRP)
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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