Cytokine Changes After Colorectal Cancer Resection
Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer
研究概览
详细说明
Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation.
The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection.
In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer.
This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Zagreb、克罗地亚、10000
- University Hospital Dubrava
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Pathohistologically verified colorectal cancer
Exclusion Criteria:
- Distant metastases noticed before or during surgery
- History of autoimmune diseases or immunodeficiencies
- Use of immunomodulatory drugs within 1 year prior to surgery
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Colorectal cancer patients
Patients with pathohistologically verified colorectal cancer or adenoma with epithelial dysplasia
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Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Postoperative changes of serum cytokine levels
大体时间：1 day, 2 days and 7 days postoperatively
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Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.
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1 day, 2 days and 7 days postoperatively
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Early postoperative complications
大体时间：Within one month after surgery
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Within one month after surgery
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合作者和调查者
调查人员
- 首席研究员：Drazen Servis, M.D., Ph.D.、University Hospital Dubrava
出版物和有用的链接
一般刊物
- Servis D, Busic Z, Stipancic I, Patrlj L, Gagro A. Serum cytokine changes after gastric resection or gastrectomy for gastric cancer. Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1868-72.
- Etherek L, Servis D, Unic A. Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Inflammatory Markers in Colorectal Cancer Surgery: A Prospective Cohort Study. Chin Med J (Engl). 2017 Nov 20;130(22):2691-2696. doi: 10.4103/0366-6999.218022.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
colorectal cancer resection的临床试验
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University Hospital, BordeauxSRIOP 2016, SIRIC BRIO完全的
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H. Lee Moffitt Cancer Center and Research InstituteNational Cancer Institute (NCI)招聘中