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Intracranial Aneurysms and Cognitive Function

2019年4月24日更新者：University Hospital of North Norway

The prevalence rate of intracranial aneurysms in the adult population is close to 5%. Rupture risk of such aneurysms causing subarachnoid hemorrhage (SAH) can be substantial.Most patients suffering from an aneurysmal SAH are in their mid life, i.e., 30 to 60 years old. Aneurysmal SAH may cause disability and mortality. The present study includes a follow-up study and a cross-sectional fMRI study. The purpose of the follow-up study is to monitor patients receiving prophylactic surgical treatment of their un-ruptured aneurysms to examine whether such treatment is associated with cognitive, psychosocial and/or neurologic sequela. The purpose of the cross-sectional fMRI study is to examine the relationship between memory function and brain activity among SAH patients. Memory impairment is often found among aneurysmal SAH patients. Using fMRI can possibly shed some light on whether such memory impairment may be caused by diffuse cerebral damage or a focal damage at the aneurysm site.

研究概览

地位

终止

条件

颅内动脉瘤

研究类型

观察性的

注册 (预期的)

100

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

挪威
- - Tromsø、挪威、N-9038
    - University Hospital of North Norway

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 75年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Patients with un-ruptured aneurysms in the anterior communicating artery and the middle cerebral artery.A subgroup of patients suffering aneurismal subarachnoid hemorrhage.

University Hospital of North Norway

描述

Inclusion Criteria:

Patients with un-ruptured aneurysms in the anterior communicating artery and the middle cerebral artery.
A subgroup of patients suffering aneurismal subarachnoid hemorrhage.

Exclusion Criteria:

History of earlier cerebrovascular, psychiatric or neurological disease.
Age older than 75 years
Lack of fluency in Norwegian
Alcohol or Substance abuse
Aphasia
Substantial vision or hearing deficits

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

观测模型：其他
时间观点：追溯

团体/队列数

队列和干预

团体/队列
Subarachnoid hemorrhage A group of patients suffering aneurismal subarachnoid hemorrhage will participate in a fMRI study.
Prophylactic surgical treatment of un-ruptured aneurysms A retrospective follow-up study of patients who have received prophylactic surgical treatment of un-ruptured aneurysms
Conservative treatment A retrospective follow-up of patients receiving conservative (life stile etc.) treatment of un-ruptured aneurysms.
Control group of healthy subjects

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Cognitive function 大体时间：Each subject will undergo one assessment of cognitive function. The assessment lasts about 2.5 hours including breaks.	Neuropsychological Assessment	Each subject will undergo one assessment of cognitive function. The assessment lasts about 2.5 hours including breaks.

次要结果测量

结果测量	措施说明	大体时间
Neurological status 大体时间：Each subject will undergo one clinical assessment of neurological status.	A clinical examination of neurological status	Each subject will undergo one clinical assessment of neurological status.
fMRI 大体时间：A subgroup of patients will participate in a fMRI study once	A subgroup of patients will participate in a fMRI study once	A subgroup of patients will participate in a fMRI study once

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

University Hospital of North Norway

合作者

University of Tromso

调查人员

学习椅：Tor Ingebrigtsen, Phd、University Hospital of North Norway

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2011年3月1日

初级完成 (实际的)

2012年1月31日

研究完成 (实际的)

2012年1月31日

研究注册日期

首次提交

2011年3月18日

首先提交符合 QC 标准的