Effects of "in UTERO" Exposure to Glucocorticoids (GLUCODEX)

Inclusion Criteria:

• Over 18 years Aged
• Males
• Women of childbearing age with a reliable and effective contraception for over 2 months
• Taking dexamethasone between the 6th and the 24th week of gestation by the mother with bloc 21-hydroxylase or normal pregnancy for control subjects
• Normal blood pressure and heart rate measured at rest: systolic blood pressure <= 150 mmHg, diastolic blood pressure <= 90 mmHg, heart rate between 55 and 90 beats/mn.
• Normal laboratory tests or not clinically significant abnormality NFS, platelets PT, aPTT, fibrin TP, TCA, Serum electrolytes, urea, creatinine Uric acid Triglycerides, total cholesterol, HDL cholesterol
• Fating bood glucose <= 6.9 mmol/l (exclusion criteria for diabetes from the American Diabetes Association) during the OGTT.
• Negative blood HCG
• Accepting the constraints of the protocol and had signed informed and free consent.
• Affiliated to the Social Security.

Exclusion Criteria:

• Affected offspring of 21-hydroxylase enzyme block
• Taking dexamethasone until pregnancy term by the mother of the subject
• Type 2 diabetes in one of the two parents and/or 1 of the 4 grandparents
• Pregnancy, Breastfeeding
• Body Mass Index (weight/height2)> 50 kg/m2
• Poisoning smoking (>10 cigarettes per day, whatever the duration of intoxication)
• Any drug taken apart from minor analgesics (aspirin, paracetamol) for less than 8 days at the inclusion and oral contraception
• Taking recent (less than 3 months) glucocorticoids either taken orally, by inhalation or percutaneously
• Current infections or recent infections (<10 days)
• Neoplastic disorders (with the exception of carcinoma in situ of the cervix or cutaneous epithelioma), haematological, cardiovascular, psychiatric, neurological
• Having donated blood or participated in a trial within 2 months preceding their inclusion