The Metabolic Effects of Breaks in Sedentary Time
2019年5月22日 更新者：Mark Tremblay、Children's Hospital of Eastern Ontario
The purpose of this study is to determine whether acute bouts of sedentary behaviour (with or without breaks and/or structured physical activity) result in measurable changes in metabolic health in children and youth.
研究概览
地位
完全的
详细说明
North American children spend the majority of their waking hours engaging in sedentary behavior (e.g.
sitting).
Research in adults and animal models suggests that even short bouts of uninterrupted siting may result in acute changes increases in cardiometabolic risk, although to date no studies have investigated this relationship in children and youth.
The purpose of this study is to assess the feasibility of a protocol which will expose participants aged 10-14 years to a full day of uninterrupted sitting, and to determine the impact of this protocol on markers of cardiometabolic risk (insulin, glucose, triglyceride, HDL-C and LDL-C) as well as subsequent food intake and physical activity.
The impact of uninterrupted sitting will be compared to the impact of interrupted sitting, with and without the inclusion of moderate physical activity.
研究类型
介入性
注册 (实际的)
19
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Ontario
-
Ottawa、Ontario、加拿大、K1N 6N5
- Behavioural Metabolic Research Unit, University of Ottawa
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
10年 至 14年 (孩子)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- Age 10-14
- Normal weight or obese
Exclusion Criteria:
- Overweight
- Overt diabetes or heart disease (or taking medications to treat this conditions)
- Being unambulatory or otherwise unable to perform the study protocol
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Sedentary
In this condition, participants will engage in 8 hours of uninterrupted sedentary behaviour.
|
In this condition, participants will engage in 8 hours of uninterrupted sedentary behaviour.
|
|
实验性的：Sedentary With Breaks
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes.
During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.
|
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes.
During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.
|
|
实验性的：Sedentary With Breaks and Physical Activity
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes.
During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.
Participants will also engage in 20 minutes of structured physical activity at an intensity of 60% of VO2peak in both the morning and afternoon.
|
In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes.
During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.
Participants will also engage in 20 minutes of structured physical activity at an intensity of 60% of VO2peak in both the morning and afternoon.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in Insulin Net Incremental Area-Under-The-Curve (iAUC)
大体时间：Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
Insulin levels will be assessed multiple times throughout the day, and the resulting values will be used to calculate AUC.
|
Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in Triglyceride Net Incremental Area-Under-The-Curve (iAUC)
大体时间：Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
Blood draws will be taken several times throughout the day, and the resulting values will be used to calculate AUC.
|
Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
|
Change in HDL-Cholesterol (HDL-C) Net Incremental Area-Under-The-Curve (iAUC)
大体时间：Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.
|
Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
|
Change in LDL-Cholesterol (LDL-C) Net Incremental Area-Under-The-Curve (iAUC)
大体时间：Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.
|
Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
|
Change in Glucose Net Incremental Area-Under-The-Curve (iAUC)
大体时间：Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
Blood draws will occur throughout the day, and the resulting values will be used to calculate AUC.
|
Baseline, 1.5, 3, 4.5, 6, and 7.5 hours
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Mark S Tremblay, OhD、Children's Hospital of Eastern Ontario Research Institute
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2011年7月1日
初级完成 (实际的)
2012年8月1日
研究完成 (实际的)
2012年8月1日
研究注册日期
首次提交
2011年7月18日
首先提交符合 QC 标准的
2011年7月19日
首次发布 (估计)
2011年7月20日
研究记录更新
最后更新发布 (实际的)
2019年7月24日
上次提交的符合 QC 标准的更新
2019年5月22日
最后验证
2019年5月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.