The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure
The relationship between the activation of the vasopressin system and central hemodynamics in heart failure (including right and left heart filling pressures and cardiac output) is not clear. The investigators intend to examine the correlation between levels of copeptin and vasopressin and the central hemodynamic system in patients with advanced (class III or IV) heart failure. The investigators also aim to examine the relationship of selected cardiac biomarkers in blood and urine with cardiac filling pressures and cardiac output in patients with decompensated heart failure.
The study population will consist of 30 patients admitted to the Department of Cardiology at Copenhagen University Hospital. Only patients for whom the attending cardiologist has already decided upon right heart catheterization for clinical/treatment reasons will be recruited for the study.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Copenhagen、丹麦
- 招聘中
- Department of Cardiology, Copenhagen University Hospital, Rigshospitalet
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接触：
- Louise Balling, MD
- 电话号码：004535452142
- 邮箱：louise.balling@dadlnet.dk
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接触：
- Finn Gustafsson, MD, PhD, DMSc
- 电话号码：004535459743
- 邮箱：finng@dadlnet.dk
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首席研究员：
- Finn Gustafsson, MD, PhD, DMSc
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Age > 18 years
- Left ventricular ejection fraction < 40 %
- Diagnosed symptomatic heart failure treated with heart failure medications for at least 30 days.
- Clinical indication for right heart catheterization for clinical/treatment reasons
- NYHA-class III-IV
- Relevant heart failure treatment as tolerated by the patient
Exclusion Criteria:
- Absence of clinical/treatment indication of right heart catheterization
- Syndrome of Inappropriate Secretion of ADH (SIADH)
- Recent acute myocardial infarction within the last 30 days
- Presence of infection or inflammatory disease
- Malignant disease
- Pregnancy
- Subjects unwilling or unable to provide written consent
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Blood and urine samples
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output
大体时间：Day 1
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Day 1
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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The correlation between levels of plasma copeptin and vasopressin with urine aquaporin-2 concentration
大体时间：Day 1
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Day 1
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The correlation between New York Heart Association (NYHA) class and levels of plasma copeptin and vasopressin
大体时间：Day 1
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Day 1
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The correlation between biomarkers levels and survival free of transplantation- and left ventricular assist device insertion
大体时间：1 year
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1 year
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合作者和调查者
调查人员
- 首席研究员：Finn Gustafsson, MD, DMSc、Rigshospitalet, Denmark
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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