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A Single Centre, Phase I, Double-blind, Randomised, Placebo-controlled Study to Investigate the Safety, Tolerability, Pharmacokinetic Profile and Effects on EEG of Single Rising Oral Doses of BIA 2-093

2016年7月19日 更新者：Bial - Portela C S.A.

A Single Centre, Phase I, Double-blind, Randomised, Placebo-controlled Study to Investigate the Safety, Tolerability, Pharmacokinetic Profile and Effects on EEG of Single Rising Oral Doses of BIA 2-093 When Given to Healthy Male Adult Volunteers.

The purpose of this study is to determine the safety and tolerability of single rising oral doses of BIA 2-093 (proposed doses 20mg, 50mg, 100mg, 200mg, 400mg, 600mg, 900mg and 1200mg) in groups of 8 healthy male adult volunteers.

研究概览

地位

完全的

条件

干预/治疗

详细说明

Single centre, Phase I, double-blind, randomised, placebo-controlled study to investigate single rising oral doses of BIA 2-093 up to 1200 mg in sequential groups of eight healthy male adult subjects. Within each group of eight subjects two subjects were randomised to receive placebo and the remaining six subjects were randomised to receive BIA 2-093. No subject was a member of more than one treatment group. Doses of 20mg, 50mg, 100mg, 200mg, 400mg, 600mg, 900mg and 1200mg were investigated in ascending order. Progression to each dose occurred only after the previous dose level was deemed to be safe and well tolerated by the investigator and the sponsor.

研究类型

介入性

注册 (实际的)

64

阶段

  • 阶段1

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 英国
      • London、英国、SE1 1YR
        • Guy's Drug Research Unit

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 35年 (成人)

接受健康志愿者

是的

有资格学习的性别

男性

描述

Inclusion Criteria:

Adult males aged 18-35 years, with a body mass index (BMI) of 19-28 kg/m2.

  • Subjects who were healthy as determined by pre-study medical history, physical examination, 12-lead ECG and EEG.
  • Subjects who had clinical laboratory tests acceptable to the investigator.
  • Subjects who were negative for HbsAg, anti-HCV and HIV I and II tests at screening.
  • Subjects who were negative for drugs of abuse and alcohol tests at screening and admission.
  • Subjects who were non-smokers or who smoked less than 10 cigarettes (or equivalent) per day.
  • Subjects who were able and willing to give written informed consent.

Exclusion Criteria:

  • Subjects who did not conform to the above inclusion criteria.
  • Subjects who had a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, connective tissue diseases or disorders.
  • Subjects who had a clinically relevant surgical history.
  • Subjects who had a clinically relevant family history.
  • Subjects who had a history of relevant atopy.
  • Subjects who had a history of relevant drug hypersensitivity (carbamazepine and related compounds)
  • Subjects who had a history of alcoholism.
  • Subjects who had a history of drug abuse.
  • Subjects who consumed more than 28 units of alcohol a week.
  • Subjects who had a significant infection or known inflammatory process on screening and/or admission
  • Subjects who had acute gastrointestinal symptoms at the time of screening and/or admission (e.g. nausea, vomiting, diarrhoea, heartburn).
  • Subjects who had an acute infection such as influenza at the time of screening and/or admission.
  • Subjects who had used prescription drugs within 4 weeks of dosing.
  • Subjects who had used over the counter medication, excluding routine vitamins but including mega dose vitamin therapy, within one week of dosing.
  • Subjects who had used any investigational drug and/or participated in any clinical trial within 3 months of admission to this study.
  • Subjects who had donated and/or received any blood or blood products within 3 months prior to screening.
  • Subjects who were vegetarians, vegans and/or had medical dietary restrictions.
  • Subjects who could not communicate reliably with the investigator.
  • Subjects who were unlikely to co-operate with the requirements of the study.
  • Subjects who were unwilling or unable to give written informed consent.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：三倍

武器和干预

参与者组/臂
干预/治疗
实验性的：Group 1 (20 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 2 (50 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 3 (100 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 4 (200 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 5 (400 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 6 (600 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 7 (900 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器
实验性的：Group 8 (1200 mg)
药品：BIA 2-093
BIA 2-093 20mg, 50 mg, 100 mg, 200 mg, 400 mg, 600 mg, 900 mg, 1200 mg
其他名称：
  • ESL，醋酸艾司利卡西平
药品：Placebo
Identical placebo administered as oral tablets with 200 ml potable water.
其他名称：
  • 可编程控制器

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Total Number of Adverse Events
大体时间：up to 20 weeks
An adverse event was defined as any undesirable event occurring to a subject during the study, whether or not related to the investigational product
up to 20 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Bial - Portela C S.A.

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2000年7月1日

初级完成 (实际的)

2000年10月1日

研究完成 (实际的)

2000年10月1日

研究注册日期

首次提交

2014年6月20日

首先提交符合 QC 标准的

2014年6月20日

首次发布 (估计)

2014年6月24日

研究记录更新

最后更新发布 (估计)

2016年7月20日

上次提交的符合 QC 标准的更新

2016年7月19日

最后验证

2016年7月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • BIA-2093-101

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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