Phase II Clinical Trial for the Evaluation of the Efficacy of Transanal TME

实验性的：经肛门全直肠系膜切除术

腹腔镜辅助经肛门全直肠系膜切除术

程序：Transanal total mesorectal excision

Subjects will have their rectal cancer removed using a technique combining surgery through the anus and standard laparoscopy. Transanal visualization will be using endoscopy. At the end of the procedure, the rectum will be removed though the anus or ileostomy formation site, the bowel will be re-connected to the anus, and a temporary diverting stoma will be created, which is standard of care following surgery for this type of cancer.

其他名称：

• Laparoscopy-assisted transanal TME

TME quality & circumferential resection margin (CRM)

The quality of the mesorectum was determined using pathology reports and scored using three grades:

• Complete: intact mesorectum with only minor irregularities of a smooth mesorectal surface. No defect is deeper than 5 mm, and there is no coning toward the distal margin of the specimen. There is a smooth circumferential resection margin on slicing.
• Nearly complete: moderate bulk to the mesorectum, but irregularity of the mesorectal surface. Moderate coning of the specimen is allowed. At no site is the muscularis propria visible, with the exception of the insertion of the levator muscles.
• Incomplete: little bulk to mesorectum with defects down onto muscularis propria and/or very irregular circumferential resection margin.

收获的淋巴结数量

30-day postoperative complications

5 年总生存期

2 年局部无复发生存期