Pilot Study on ST Elevation Acute Myocardial Infarction (ARGEN-IAM-ST)
Relevamiento / Encuesta Nacional de Infarto Agudo de Miocardio Con elevación Del ST
研究概览
地位
条件
详细说明
Cardiovascular disease is the most common cause of death in the world and in Argentina, as well as a cause of disability and loss of work capacity in adults. Treatment of various forms of serious diseases such as acute ischemic events and heart failure are now supported by scientific studies and allow a markedly reduction in disability and mortality. Access to diagnostic and therapeutic strategies require proper coordination of the health system and far exceed the role of specialists. Given the frequency of these diseases, it is essential to have information on the prevalence and treatment, and the various barriers to access to diagnosis and appropriate treatment. Both for the basic knowledge to evaluate the relevance and effectiveness of corrective action a record of pathologies is required, with information accurate enough to enable the adoption of public policies, and adjusted to national needs.
Scientific societies in cardiovascular field, Argentine Society of Cardiology and Argentine Federation of Cardiology, have a long history of registers and educational programs to improve cardiovascular care. However, these tasks are limited to institutions with academic programs and probably do not reach the majority of our population.
A national survey of high prevalence of cardiovascular diseases, starting with acute myocardial infarction with ST segment elevation, together with the authorities of the National Ministry of Health, would put Argentina at the level of most developed countries in this subject. Knowledge of general and local barriers will allow a rapid implementation of corrective measures and the evaluation of their impact through the permanent record. Improving the quality of cardiovascular patient care, optimizing adherence to standards of diagnosis and treatment can be achieved through different paths as self-knowledge of the institutions of their level of performance and dissemination of coordination measures, generating systematic referral and care networks, diagnostic support systems such as telemedicine, and others that can be assessed globally or regionally according to the identified problems.
Networking will also enable the implementation of initiatives that will result in an increase in the quality of care and generate epidemiological research projects that enhance patient care and outcomes. In conclusion, it will allow to know the problems in depth and adopt measures to improve the quality of care and reduce morbidity and mortality.
The main objective of the survey is to register at national level, in the broadest possible way trying to reach the "universe" of care for this disease in Argentina, aspects of clinical, delays, treatment schedules and results, with sufficient information to quickly allow the adoption of policies to improve the quality of care and subsequent control.
Its fulfilment arises in stages:
- Develop a national survey of myocardial infarction with ST segment elevation, aimed at characterization of current evolutions and possible barriers to be improved.
- Based on the results, configure an advisory group for public policies in this area to suggest global and regional measures.
- Upon completion of the survey, consolidation of a permanent network of cardiovascular disease registry to assess the impact of public policies and their progressive adjustment under the Federal Cardiovascular Disease Registry A national survey of all AMI with ST segment elevation admitted to intensive care areas across the country will take place over a period of 3 consecutive months in each centre.
The inclusion criteria are:
- Patients admitted with AMI and ST-segment elevation.
- AMI evolved with new Q waves less than 36 hours evolution.
- Suspected inferoposterior AMI (horizontal ST depression in V1 to V3, suggestive of acute circumflex coronary artery occlusion).
- New or presumed new left bundle branch block.
Exclusion criteria:
- Acute coronary syndrome without ST elevation or non-Q AMI
- Myocardial infarction of more than 36 hours of evolution. Data on patient characteristics (age, gender, risk factors, history, comorbidities), of the clinical conditions (infarct location, Killip on admission, duration of symptoms), treatments (antiplatelet drugs, reperfusion therapy, adjuvant treatment) and in-hospital (heart failure, post-infarction angina, shock, death) and 30-day evolution will be collected. Emphasis will be placed on the delays for effective treatment. 30 days follow-up will be done by telephone or in person by each centre investigator or through the central coordinating committee.
The data collection will take place in an electronic record specially designed, via web, allowing constant monitoring of the input data. The survey data will be verified or confronted with source documents in at least 30% of the patients included in the survey.
The data analysis will be conducted by a committee of representatives of the organizing researchers of Scientific Societies and the Ministry of Health, presented in relevant scientific meetings and published in the journals of both Societies.
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Juan Gagliardi, PhD
- 电话号码:00 +54 114961-6027
- 邮箱:jgagliardi@fibertel.com.ar
研究联系人备份
- 姓名:Carlos D Tajer, MD
- 电话号码:00 +54 114961-6027
- 邮箱:ctajer@gmail.com
学习地点
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Buenos Aires
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Ciudad Autónoma de Buenos Aires、Buenos Aires、阿根廷、1115
- 招聘中
- Sociedad Argentina de Cardiología
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接触:
- Juan Gagliardi, PhD
- 电话号码:+54 114961-6027
- 邮箱:jgagliardi@fibertel.com.ar
-
接触:
- Carlos D Tajer, MD
- 电话号码:+54 114961-6027
- 邮箱:ctajer@gmail.com
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients admitted with AMI and ST-segment elevation.
- AMI evolved with new Q waves less than 36 hours evolution.
- Suspected inferoposterior AMI (horizontal ST depression in V1 to V3, suggestive of acute circumflex coronary artery occlusion).
- New or presumed new left bundle branch block.
Exclusion Criteria:
- Acute coronary syndrome without ST elevation or non-Q AMI
- Myocardial infarction of more than 36 hours of evolution.
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Appropriate use of reperfusion therapy
大体时间:In-hospital, with an expected average of 5 days.
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Timely initiation of reperfusión (door to needle time <30 minutes or door to balloon time <90 minutes).
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In-hospital, with an expected average of 5 days.
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In-hospital mortality
大体时间:In-hospital, with an expected average of 5 days.
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All cause death during initial hospitalization.
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In-hospital, with an expected average of 5 days.
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All cause mortality
大体时间:30 days.
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All cause mortality between symptoms onset and 30 days.
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30 days.
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
In-hospital complications
大体时间:In-hospital, with an expected average of 5 days.
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Heart failure, post-infarction angina, cardiogenic shock or death during initial hospitalization.
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In-hospital, with an expected average of 5 days.
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合作者和调查者
调查人员
- 学习椅:Juan Gagliardi, PhD、+54 114961-6027
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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