Observational Study on Intubation in Septic Shock (INTUBATIC)
Septic shock is common in intensive care and its mortality remains high. While new treatments have not improved survival, optimization of known and widely used techniques has allowed reduction in mortality. Thus improving care given to patients starts with making better use of existing resuscitation techniques. Among these practices, mechanical ventilation is widespread in the management of patients with septic shock. In large studies published in recent years in Europe and North America, 40 to 85% of patients receive invasive mechanical ventilation. It therefore appears that a significant proportion of patients are never intubated during treatment and management of their septic shock. There is no specific recommendation from critical care societies concerning mechanical ventilation in the treatment of septic shock. Apart from indisputable situations such as impaired consciousness or acute respiratoire distress, the decision whether to ventilate mechanically or not is left to the discretion of the physician.
The aim of this study is to analyze intubation practice in septic shock patients and its impact on 28-day survival.
This multicentric and observational study will be conducted in 30 French ICUs.
研究概览
地位
条件
研究类型
注册 (实际的)
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- older than 18 years old
- Admitted in the ICU for septic shock
- Introduction of vasopressors ( norepinephrine or adrenaline ) in the ICU or within 24 hours of ICU admission
- Suspected or proven infection
Exclusion Criteria:
- Intubation before the introduction of vasopressors
- Decision of withdrawing or withholding care at admission
- Pregnant woman
- Patient not affiliated to the social security insurance
- Refusal of participation in the study
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
|---|
|
Patients with septic shock
|
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
death
大体时间:28 days after ICU admission
|
28 days after ICU admission
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
duration of organ support
大体时间:28 days
|
mechanical ventilation, vasopressors, renal replacement therapy
|
28 days
|
|
impact of intubation delay on outcome
大体时间:28 days
|
28 days
|
合作者和调查者
出版物和有用的链接
一般刊物
- Mellado-Artigas R, Ferrando C, Martino F, Delbove A, Ferreyro BL, Darreau C, Jacquier S, Brochard L, Lerolle N. Early intubation and patient-centered outcomes in septic shock: a secondary analysis of a prospective multicenter study. Crit Care. 2022 Jun 7;26(1):163. doi: 10.1186/s13054-022-04029-6.
- Darreau C, Martino F, Saint-Martin M, Jacquier S, Hamel JF, Nay MA, Terzi N, Ledoux G, Roche-Campo F, Camous L, Pene F, Balzer T, Bagate F, Lorber J, Bouju P, Marois C, Robert R, Gaudry S, Commereuc M, Debarre M, Chudeau N, Labroca P, Merouani K, Egreteau PY, Peigne V, Bornstain C, Lebas E, Benezit F, Vally S, Lasocki S, Robert A, Delbove A, Lerolle N. Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study. Ann Intensive Care. 2020 May 24;10(1):62. doi: 10.1186/s13613-020-00668-6.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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