Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest
研究概览
详细说明
Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world. The constitution of the atheroma plaque is linked to the deregulation of several biological phenomena, including angiogenesis, adipogenesis, inflammatory response, lipid metabolism and oxidative stress. In addition to its anatomical and physiological characteristics, the notion of plate stability is of paramount importance for clinical implications. This stability depends largely on the biological composition of the plate. A vulnerable or unstable plaque often has a large lipid body consisting of foam cells (macrophages laden with oxidized LDL) with a thin fibrous screed consisting of smooth muscle cells (CML), collagen fibers and extracellular matrix. This plaque is also made up of numerous inflammatory cells including macrophages, rich vascularization and intraplate hemorrhage. Although the cell composition of the unstable plate is still relatively established, its molecular analysis remains little known.
The benefit of carotid surgery in asymptomatic patients with stenosis greater than 70% is increasingly controversial given the moderate risk of spontaneous stroke under optimal medical treatment. This annual average risk is less than 5%. Thus, the discovery of an original and innovative biomarker, predictive of plate rupture, would define the patients most at risk, who benefit most from this surgery.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Picardie
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Amiens、Picardie、法国、80054
- 招聘中
- CHU Amiens Picardie
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接触：
- Thierry REIX, PhD
- 电话号码：+33322455929
- 邮箱：reix.thierry@chu-amiens.fr
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Any adult with a carotid thrombo endarterectomy,
- affiliated to a social security scheme,
- informed of the study and not opposed to it.
Exclusion Criteria:
- Any person benefiting from an iterative carotid surgery,
- or refusing to participate in the study,
- or not being able to express its consent.
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Symptomatic patients
in the department with carotid plaque Comparing the expression of miRNAs
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by PCR, in symptomatic and asymptomatic carotid plaques.
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Asymptomatic patients
in consultation with carotid plaque Comparing the expression of miRNAs
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by PCR, in symptomatic and asymptomatic carotid plaques.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Analysis of the miRNAs
大体时间：3 years
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by PCR of the composition of the atheroma plaque
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3 years
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合作者和调查者
调查人员
- 首席研究员：Thierry REIX, PhD、CHU Amiens-Picardie
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- PI2012_843_0019
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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Comparing the expression of miRNAs的临床试验
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Radboud University Medical CenterZonMw: The Netherlands Organisation for Health Research and Development未知