The Diversity of the Fungal and Bacterial in Colon Mucosa of Patients With Different Degree of Inflammation of Ulcerative Colitis
2017年5月10日 更新者：Xiuli Zuo
The Diversity of the Fungal and Bacterial in Colon Mucosa of Patients With Ulcerative Colitis Associated Different Clinical Classification
We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.
研究概览
详细说明
In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed.
We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group.
Analyzing the diversity of the fungal and bacterial within colon mucosa between patients with different clinical classification, for example, the proportion of bacteria and fungi, the proportion of candida albicans, the proportion of yeasts, and so on.
研究类型
观察性的
注册 (预期的)
50
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Xiuli Zuo, PhD
- 电话号码：053188369277 15588818685
- 邮箱：zuoxiuli@sina.com
学习地点
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Shandong
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Jinan、Shandong、中国、250012
- 招聘中
- Qilu Hospital, Shandong University
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接触：
- Xiuli Zuo, PhD
- 电话号码：053188369277 15588818685
- 邮箱：zuoxiuli@sina.com
-
副研究员：
- Lidong Xu, MD
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 80年 (成人、年长者)
接受健康志愿者
是的
有资格学习的性别
全部
取样方法
非概率样本
研究人群
Consecutive patients under endoscopic surveillance or examination at Qilu Hospital were considered for inclusion.
描述
Inclusion Criteria:
- Patients at our tertiary care medical center, aged between 18 and 80 years, scheduled to undergo surveillance colonoscopy.
- The patients with ulcerative colitis for ulcerative colitis group.
- The patients without ulcerative colitis for control group.
- 18-80 years.
Exclusion Criteria:
- Using antibiotics, glucocorticoid and immunosuppressants wintin one month.
- There are contraindications for enteroscopy and biopsy.
- There are other intestinal diseases.
- Pregnancy or breast-feeding women.
- Patients with serious lung disease and mental illness.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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ulcerative colitis
We analysed the diversity of the fungal and bacterial in patients with Ulcerative Colitis (UC).
We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
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We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
其他名称：
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Control
Analysing the diversity of the fungal and bacterial in patients without ulcerative colitis.
We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
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We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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fungus detection rate
大体时间：6 months
|
Fungi detection rate was defined as the percentage of patients in whose colonic mucosa at least one kind of fungus were identified.
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6 months
|
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yeasts detection rate
大体时间：6 months
|
Yeasts detection rate was defined as the percentage of patients in whose colonic mucosa yeasts were identified.
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6 months
|
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candida albicans detection rate
大体时间：6 months
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Candida albicans detection rate was defined as the percentage of patients in whose colonic mucosa candida albicans were identified.
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6 months
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
赞助
调查人员
- 首席研究员：Xiuli Zuo, PhD、Qilu Hospital Of Shandong University
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Sokol H, Leducq V, Aschard H, Pham HP, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I, Cosnes J, Seksik P, Langella P, Skurnik D, Richard ML, Beaugerie L. Fungal microbiota dysbiosis in IBD. Gut. 2017 Jun;66(6):1039-1048. doi: 10.1136/gutjnl-2015-310746. Epub 2016 Feb 3.
- Mukhopadhya I, Hansen R, Meharg C, Thomson JM, Russell RK, Berry SH, El-Omar EM, Hold GL. The fungal microbiota of de-novo paediatric inflammatory bowel disease. Microbes Infect. 2015 Apr;17(4):304-10. doi: 10.1016/j.micinf.2014.12.001. Epub 2014 Dec 15.
- Eriksson M, Johannssen T, von Smolinski D, Gruber AD, Seeberger PH, Lepenies B. The C-Type Lectin Receptor SIGNR3 Binds to Fungi Present in Commensal Microbiota and Influences Immune Regulation in Experimental Colitis. Front Immunol. 2013 Jul 16;4:196. doi: 10.3389/fimmu.2013.00196. eCollection 2013.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2016年7月1日
初级完成 (预期的)
2017年8月1日
研究完成 (预期的)
2017年8月1日
研究注册日期
首次提交
2016年12月19日
首先提交符合 QC 标准的
2017年5月10日
首次发布 (实际的)
2017年5月12日
研究记录更新
最后更新发布 (实际的)
2017年5月12日
上次提交的符合 QC 标准的更新
2017年5月10日
最后验证
2017年5月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.