Preoperative Chemo-radiation With IG-IMRT Dose Escalation for Locally Advanced Rectal Cancers (RADICAL)
Preoperative Chemo-radiation With IG-IMRT Dose Escalation for Locally Advanced Rectal Cancers: Phase 2 Study (RADICAL)
Hypothesis : Therapeutic intensification by increasing the dose delivered to the tumor by RCMI (conformational radiotherapy by intensity modulation) in order to reduce local relapse, often associated with poor prognosis
Primary objective: evaluate the rate of tumor sterilization and the toxicities of RTCT with concomitant boost in intensity modulation in patients with rectal cancer CT3-T4 and / or cN1-2.
研究概览
地位
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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-
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Besançon、法国、25030
- CHRU De Besancon
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Dijon、法国、21000
- Centre GF Leclerc
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Adenocarcinoma of the rectum cT3 or cT4 or cN+, M0 and for which CPR recommends preoperative radiochemotherapy
- Tumor <15 cm of the anal margin in rigid or subperitoneal rectoscopy at the MRI
- Tumor potentially resectable from the outset, or considered to be resectable after radiochemotherapy
- Operable Patient
- Age between 18 and 75
- OMS performance status 0-2
- No co-morbidity likely to prevent the delivery of treatment
- Adequate contraception for men, and for non-menopausal women
- Neurotrophic neutrophils 1500 / mm3, platelets 100 000 / mm3, and hemoglobin 10 g / dL
- Bilirubin ≤ 1.5 times the upper limit of normal (LNS), ASAT and ALAT ≤ 1.5LNS, Alkaline phosphatase ≤ 1.5 LNS
- Creatinine clearance> 50 mL / min
- Patient must have been informed and must have signed the specific informed consent form.
- Patient must be affiliated to a Social Health Insurance.
Exclusion Criteria:
- Remote metastasis
- Cancer not resectable
- Contraindication to capecitabine and its excipients
- Previous history of pelvic radiotherapy or previous chemotherapy
- History of inflammatory bowel or rectum disease
- History of angina pectoris monitored or myocardial infarction or heart failure
- Active active infection or other serious underlying condition that may prevent the patient from receiving treatment
- Other concomitant cancer, or history of cancer other than in situ cancer of the treated cervix or basal cell carcinoma or squamous cell carcinoma
- Patient already included in another therapeutic trial with an experimental molecule
- Pregnant woman, likely to be pregnant or nursing
- Persons deprived of their liberty or under guardianship
- Patient unable to comply with the required medical follow-up for geographic, social or psychological reasons
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:不适用
- 介入模型:单组作业
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:Treatment
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Complete histological response rate
大体时间:at 8 weeks after inclusion
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Absence of residual cancer cells on the final analysis of the tumor and lymph node
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at 8 weeks after inclusion
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Tolerance
大体时间:at 1, 2, 3, 4, 5 and 13 weeks after inclusion and at 2, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33 and 36 months after surgery
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Toxicity is assessed according to the NCI-CTCAE toxicity scale version 4.0
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at 1, 2, 3, 4, 5 and 13 weeks after inclusion and at 2, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33 and 36 months after surgery
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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Advanced Rectal Cancers的临床试验
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