Outcome After TIPS
Retrospective Analysis of Outcome After Implantation of a Transjugular Intrahepatic Portosystemic Shunt (TIPS)
研究概览
详细说明
The implantation of a Transjugular Intrahepatic Portosystemic Shunt (TIPS) is a valuable measure to reduce portal hypertension and prevent portal hypertension-related complications. It can be used as a symptomatic treatment in patients with chronic portal hypertension as well as for the treatment of active variceal bleedings or large gastrointestinal varices that go along with threatening bleeding danger.
However, this invasive procedure carries a high risk for complications. 30-days mortality after TIPS implantation amounts between 4% and 45%.
A common complication is the (initial) manifestation or deterioration of hepatic encephalopathy, which occurs in 33-46 % after TIPS implantation.
Other complications that are directly related to the intervention are bleeding, infections and stent migration.
Aim of this retrospective single centre study is to investigate the long-term outcome after TIPS implantation with regard to transplantation free survival and time to (re-) occurrence of portal hypertension-related complications, especially ascites and hepatic encephalopathy.
Intervention-related complications as well as long-term effects should be evaluated to facilitate the decision for or against TIPS.
研究类型
注册 (实际的)
联系人和位置
学习地点
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-
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Graz、奥地利、8010
- Medical University of Graz
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- every person at the age of 18-90 years who received a Transjugular Intrahepatic Portosystemic Shunt at the University Hospital of Graz/Austria between 1.1.2004 and 31.12.2017
Exclusion Criteria:
- age under 18
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
transplantation free survival
大体时间：from date of TIPS until the event, up to 4 years
|
Survival without liver Transplantation in days
|
from date of TIPS until the event, up to 4 years
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
occurrence of hepatic encephalopathy
大体时间：from date of TIPS until the event, up to 4 years
|
time to occurrence of the first episode of hepatic encephalopathy in days
|
from date of TIPS until the event, up to 4 years
|
|
occurrence of ascites
大体时间：from date of TIPS until the event, up to 4 years
|
time to (re)occurrence of ascites in days
|
from date of TIPS until the event, up to 4 years
|
合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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