Prevalence and Characteristics of Patients With Bronchiectasis Comorbid Nontuberculous Mycobacteria
Prevalence and Clinical Characteristics of Patients With Bronchiectasis With Comorbid Nontuberculous Mycobacteria Among Middle-aged and Old Women
研究概览
地位
详细说明
The development of bronchiectasis is closely related to chronic infection of pathogenic microorganisms .Bronchiectasis and nontuberculous mycobacterial (NTM) infections are inextricably linked Pathophysiologically. But the incidence rate and characteristics of NTM infections among patients with bronchiectasis remains unclear in mainland China.
In this study, we will collect data of participants about demographic ,co-morbidities ,spirometry, mMRC score ,exacerbation history, QOL-B questionnaire, aetiology, spirometry , HRCT(or CT) scan ,results of microbiology samples and treatments, collect three consecutive sputum(or induced sputum) samples to smear, bacteria culture, acid-fast stain, mycobacterium cultivation and identification, drug susceptibility testing of nontuberculous mycobacteria.To estimate the prevalance of non-tuberculous mycobacterial(NTM) infections in Middle-aged and old women patients with bronchiectasis in northern China. To analyze clinical manifestations and microbiological characteristics of patients with bronchiectasis comorbid NTM infections By 16SRNA and gene sequencing.
In addition, A cross-sectional investigation about lung function and clinical data will be done among patients who have confirmed bronchiectasis with NTM from February 2017 to December 2020.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Beijing、中国、100029
- 招聘中
- China-Japan Friendship Hospital
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接触：
- Hongjun Yin, MD
- 电话号码：86 13621089726
- 邮箱：yhjh1101@163.com
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首席研究员：
- Hongjun Yin, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Middle-aged and old women who are > or = 50 years of age
- Patients meet the criteria of bronchiectasis
Exclusion Criteria:
- Cystic fibrosis
- After organ transplantation
- Activity tumor (malignant solid tumor and blood system tumor)
- Pulmonary interstitial fibrosis with bronchus dilation
- Allergic bronchopulmonary aspergillosis
- Diffuse panbronchiolitis
- Patients refused to sign the informed consent
- Patients unable to return sputum specimens
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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NTM infection rates
大体时间：24 months afer enrolled participants
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NTM infection rates in Middle-aged and old women patients with bronchiectasis in northern China
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24 months afer enrolled participants
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
clinical characteristics of patients with bronchiectasis comorbid NTM infections
大体时间：24 months afer enrolled participants
|
clinical manifestations of patients with bronchiectasis comorbid NTM infections
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24 months afer enrolled participants
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microbiological characteristics of patients with bronchiectasis comorbid NTM infections
大体时间：24 months afer enrolled participants
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microbiological characteristics of patients with bronchiectasis comorbid NTM
|
24 months afer enrolled participants
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Drug resistance of NTM
大体时间：24 months afer enrolled participants
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drug susceptibility testing outcomes of nontuberculous mycobacteria from sputum samples
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24 months afer enrolled participants
|
合作者和调查者
赞助
调查人员
- 学习椅：Ben Cao, MD、China-Japan Friendship Hospital
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2018-62-K46
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