The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis
Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.
Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Elazığ、火鸡、23000
- 招聘中
- Songul Baglan Yentur
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接触：
- Songul B Yentur
- 电话号码：+90 506 272 6511
- 邮箱：songulbaglan23@hotmail.com
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patients who were aged between 18-65 years,
- Patients who got diagnosed according to American College of Rheumatology criteria
- Patients who were being followed at Firat University Department of Rheumatology
Exclusion Criteria:
- Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
- Patients who took anti-TNF treatment
- Patients who had changes of medical treatment in last 3 months
- Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
- Patients who had cardiac symptoms according to New York Heart Association
- Patients who had dysfunction that can prevent physical activity
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：学习小组
有氧运动将进行一次
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将对所有参与者进行一次有氧运动。
计算每个受试者（220 - 年龄）的最大心率，并使用心率监测器（Polar FT 100，中国）跟踪受试者在有氧运动期间的心率。
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有源比较器：控制组
对健康人群进行单次有氧运动
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将对所有参与者进行一次有氧运动。
计算每个受试者（220 - 年龄）的最大心率，并使用心率监测器（Polar FT 100，中国）跟踪受试者在有氧运动期间的心率。
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Irisin
大体时间：1 minute
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Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention.
Obtained serums will be stored at the laboratories of Firat University.
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1 minute
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho
大体时间：1 minute
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Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention.
Obtained serums will be stored at the laboratories of Firat University.
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1 minute
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合作者和调查者
出版物和有用的链接
一般刊物
- Grimsholm O, Rantapaa-Dahlqvist S, Dalen T, Forsgren S. BDNF in RA: downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parameters. Clin Rheumatol. 2008 Oct;27(10):1289-97. doi: 10.1007/s10067-008-0910-4. Epub 2008 May 17.
- Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res. 2015 Jan;60:56-64. doi: 10.1016/j.jpsychires.2014.10.003. Epub 2014 Oct 12.
- Ercan Z, Deniz G, Yentur SB, Arikan FB, Karatas A, Alkan G, Koca SS. Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients. Ir J Med Sci. 2022 Mar 16. doi: 10.1007/s11845-022-02970-7. Online ahead of print.
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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