Assessment of the Effects of Extensive Somatosensory Training on Pain Processing
2022年2月15日 更新者：Anna M. Zamorano、Aalborg University
Assessment of the Effects of Extensive Sensorimotor Training on Pain Processing
Persistent pain may lead to several alterations in the brain activity and sensory perception (i.e.
pain).
Around 80% of professional musicians experience prolonged episodes of musculoskeletal pain throughout their careers, a percentage that is four times higher than in the general population.
With this background, the intended experiment aims at understanding the role of several biological factors associated to sensorimotor training that can lead to alteration of the brain activity and, consequently, pain processing.
研究概览
研究类型
观察性的
注册 (实际的)
100
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Nordjylland
-
Aalborg、Nordjylland、丹麦、9000
- Aalborg University
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 60年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
取样方法
概率样本
研究人群
Healthy men and women Speak and understand English.
描述
Inclusion Criteria:
Healthy men and women Speak and understand English.
General exclusion criteria are:
- Pregnancy
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Previous neurologic or mental illnesses
- Presence of a history of trauma or neurologic entrapment syndromes to the arm regions.
- Lack of ability to cooperate
- Frequent computer gamer ( > 9 hours/week)
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Healthy musicians
Men and women aged 18-60, who must be enrolled in a music conservatory performance program or be professionally active, and must speak and understand English.
|
Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor.
|
|
Healthy non-musicians
Men and women aged 18-60, must speak and understand English and not have any kind of musical training.
|
Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor.
|
|
Musicians with chronic pain
Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months.
They must be enrolled in a music conservatory performance program or be professionally active and must speak and understand English.
|
Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor.
|
|
Non-musicians with chronic pain
Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months.
They must not have any kind of musical training and must speak and understand English.
|
Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Pain rating
大体时间：Changes from baseline measured at day 3 and day 8
|
Pain on an 11-point numerical rating scale (0 = no pain, 10 = most intense pain imaginable)
|
Changes from baseline measured at day 3 and day 8
|
|
Cortical Sensory Evoked Potentials
大体时间：Changes from baseline measured at day 3 and day 8
|
Electrical stimulation will be elicited to record sensory evoked potentials using electroencephalography (EEG)
|
Changes from baseline measured at day 3 and day 8
|
|
Motor Evoked Potentials
大体时间：Changes from baseline measured at day 3 and day 8
|
Transcranial magnetic stimualtion will be used to evoke motor evoked potentials (MEPs)
|
Changes from baseline measured at day 3 and day 8
|
|
Brain connectivity
大体时间：Changes from baseline measured at day 3 and day 8
|
Continuous electroencephalography recording will be used to explore connectivity between brain areas
|
Changes from baseline measured at day 3 and day 8
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Questionnaires
大体时间：Changes from baseline measured at day 3 and day 8
|
Questionnaires about pain and muscle soreness (Pain catastrophization; State and Trait anxiety; Pain vigilance)
|
Changes from baseline measured at day 3 and day 8
|
|
Pressure pain thresholds
大体时间：Changes from baseline measured at day 3 and day 8
|
Pressure applied to the surface of the skin using a handheld algometer
|
Changes from baseline measured at day 3 and day 8
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2017年10月1日
初级完成 (实际的)
2018年10月1日
研究完成 (实际的)
2020年7月1日
研究注册日期
首次提交
2020年6月24日
首先提交符合 QC 标准的
2020年7月2日
首次发布 (实际的)
2020年7月7日
研究记录更新
最后更新发布 (实际的)
2022年3月3日
上次提交的符合 QC 标准的更新
2022年2月15日
最后验证
2022年2月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.