Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance Volume Profile in Children
Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance-volume Profile in Children
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Seoul、大韩民国、110-744
- Seoul National University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Children undergoing surgery > 1 hour under general anesthesia
- Children ≤ 6 years
- American society of anesthesiology physical status I, II
Exclusion Criteria:
- Previous lung surgery
- Bronchopulmonary dysplasia, respiratory distress syndrome
- Other interstitial lung disease
- Laparoscopic surgery
- Thoracic surgery, abdominal surgery
学习计划
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Evaluation of intratidal compliance
When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order.
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When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Intratidal compliance profiles in each ventilator settings
大体时间：During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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The investigators will determine Intratidal compliance profile using the changes in compliance over time --> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high. |
During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Respiratory compliance
大体时间：During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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ml cmH2O-1
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During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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Driving pressure
大体时间：During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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cmH2O
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During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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Blood pressure
大体时间：During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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mmHg
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During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- H2009-175-1162
计划个人参与者数据 (IPD)
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