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PNF Versus Cryotherapy in Delayed Onset Muscle Soreness

2026年6月13日 更新者：Sara Perpiñá、Universidad Pontificia de Salamanca

Efficacy of Proprioceptive Neuromuscular Facilitation Versus Cryotherapy and Placebo on Delayed Onset Muscle Soreness: A Randomized Pilot Clinical Trial

This randomized, double-blind, single-center pilot clinical trial evaluated three interventions for delayed onset muscle soreness in the hamstring muscles.

Twenty-nine untrained adults were included. Delayed onset muscle soreness was induced using two eccentric hamstring exercises. Participants were then assigned to one of three groups: proprioceptive neuromuscular facilitation, local cryotherapy, or placebo consisting of water with sugar.

The main outcome was pressure pain threshold in the hamstring muscles. Other outcomes included knee range of motion, hamstring strength, pain intensity, perceived exertion, and blood lactate levels. Measurements were taken before the eccentric exercise, 24 hours after exercise before treatment, immediately after treatment, and 48 hours after exercise.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

29

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 西班牙
    • Madrid
      • Madrid、Madrid、西班牙、28015
        • Clínica Universitaria Salus Infirmorum, Universidad Pontificia de Salamanca

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

是的

描述

Inclusion Criteria:

  • Adults aged between 18 and 45 years.
  • Participants who did not usually perform physical exercise or whose exercise was not focused on the lower limbs.
  • Participants who had previously experienced delayed onset muscle soreness and were familiar with its effects.

Exclusion Criteria:

  • Musculoskeletal injury of the lower limb.
  • Pregnancy.
  • Diabetes.
  • Cardiovascular problems.
  • History of cancer.
  • Autoimmune diseases, including Raynaud disease or rheumatoid arthritis.
  • Sensory disorders.
  • Skin disorders.
  • Skin conditions.
  • Peripheral venous or lymphatic vascular insufficiency.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：单身的

武器和干预

参与者组/臂
干预/治疗
实验性的：Proprioceptive Neuromuscular Facilitation
Participants received a proprioceptive neuromuscular facilitation intervention targeting the hamstring muscles 24 hours after eccentric exercise-induced delayed onset muscle soreness.
其他：Proprioceptive Neuromuscular Facilitation
A contract-relax-antagonist-contract proprioceptive neuromuscular facilitation technique was applied to the hamstring muscles. The protocol included isometric hamstring contraction, rest, quadriceps contraction, and passive movement into a deeper hamstring stretch. The protocol was repeated twice on each leg.
实验性的：Cryotherapy
Participants received local cryotherapy over the hamstring muscles 24 hours after eccentric exercise-induced delayed onset muscle soreness.
其他：Local Cryotherapy
Participants were placed in prone position and an ice pack was applied over the hamstring muscles for 20 minutes. A thin cloth was placed between the ice pack and the skin to avoid direct contact.
安慰剂比较：water with sugar
Participants received a placebo intervention consisting of water with sugar 24 hours after eccentric exercise-induced delayed onset muscle soreness.
其他：Placebo: Water With Sugar
Participants consumed 200 mL of water with 5 g of dissolved sugar after the eccentric exercise protocol.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Change in Pressure Pain Threshold in the Hamstring Muscles
大体时间：Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Pressure pain threshold was assessed using a pressure algometer over three points of maximum pain in the hamstring muscles. Three measurements were taken and the mean value was calculated.
Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise

次要结果测量

结果测量
措施说明
大体时间
Change in Active Knee Range of Motion
大体时间：Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Active knee flexion and extension range of motion were assessed using a manual goniometer.
Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Change in Hamstring Muscle Strength
大体时间：Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Maximum hamstring strength was assessed using a handheld dynamometer.
Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Change in Blood Lactate Concentration
大体时间：Before exercise, immediately after exercise, and 48 hours after exercise
Blood lactate concentration was measured using a Lactate Edge device.
Before exercise, immediately after exercise, and 48 hours after exercise
Change in Pain Intensity
大体时间：Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Pain intensity was assessed using the 11-point Numeric Pain Rating Scale. Scores range from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity and therefore a worse outcome.
Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
Perceived Exertion After Eccentric Exercise
大体时间：Immediately after eccentric exercise
Perceived exertion was assessed using the Modified Borg Rating of Perceived Exertion Scale after completion of the eccentric exercise protocol. Scores range from 0 to 10, where 0 indicates no exertion and 10 indicates maximal exertion. Higher scores indicate greater perceived exertion and therefore a worse outcome.
Immediately after eccentric exercise

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Universidad Pontificia de Salamanca

调查人员

  • 首席研究员：Sara Perpiña Martínez, PhD、Universidad Pontificia de Salamanca

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2025年1月1日

初级完成 (实际的)

2025年4月26日

研究完成 (实际的)

2025年4月30日

研究注册日期

首次提交

2026年5月28日

首先提交符合 QC 标准的

2026年5月28日

首次发布 (实际的)

2026年6月3日

研究记录更新

最后更新发布 (实际的)

2026年6月16日

上次提交的符合 QC 标准的更新

2026年6月13日

最后验证

2026年6月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • UPSA-DOMS-2025

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

是的

IPD 计划说明

De-identified individual participant data related to the outcomes reported in the study may be shared upon reasonable request to the principal investigator. Data will only be shared for academic and research purposes, after approval by the study team, and in accordance with applicable data protection regulations.

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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