PNF Versus Cryotherapy in Delayed Onset Muscle Soreness
13 juni 2026 uppdaterad av: Sara Perpiñá, Universidad Pontificia de Salamanca
Efficacy of Proprioceptive Neuromuscular Facilitation Versus Cryotherapy and Placebo on Delayed Onset Muscle Soreness: A Randomized Pilot Clinical Trial
This randomized, double-blind, single-center pilot clinical trial evaluated three interventions for delayed onset muscle soreness in the hamstring muscles.
Twenty-nine untrained adults were included. Delayed onset muscle soreness was induced using two eccentric hamstring exercises. Participants were then assigned to one of three groups: proprioceptive neuromuscular facilitation, local cryotherapy, or placebo consisting of water with sugar.
The main outcome was pressure pain threshold in the hamstring muscles. Other outcomes included knee range of motion, hamstring strength, pain intensity, perceived exertion, and blood lactate levels. Measurements were taken before the eccentric exercise, 24 hours after exercise before treatment, immediately after treatment, and 48 hours after exercise.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Faktisk)
29
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Madrid
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Madrid, Madrid, Spanien, 28015
- Clínica Universitaria Salus Infirmorum, Universidad Pontificia de Salamanca
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
Tar emot friska volontärer
Ja
Beskrivning
Inclusion Criteria:
- Adults aged between 18 and 45 years.
- Participants who did not usually perform physical exercise or whose exercise was not focused on the lower limbs.
- Participants who had previously experienced delayed onset muscle soreness and were familiar with its effects.
Exclusion Criteria:
- Musculoskeletal injury of the lower limb.
- Pregnancy.
- Diabetes.
- Cardiovascular problems.
- History of cancer.
- Autoimmune diseases, including Raynaud disease or rheumatoid arthritis.
- Sensory disorders.
- Skin disorders.
- Skin conditions.
- Peripheral venous or lymphatic vascular insufficiency.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Enda
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
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Experimentell: Proprioceptive Neuromuscular Facilitation
Participants received a proprioceptive neuromuscular facilitation intervention targeting the hamstring muscles 24 hours after eccentric exercise-induced delayed onset muscle soreness.
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A contract-relax-antagonist-contract proprioceptive neuromuscular facilitation technique was applied to the hamstring muscles.
The protocol included isometric hamstring contraction, rest, quadriceps contraction, and passive movement into a deeper hamstring stretch.
The protocol was repeated twice on each leg.
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Experimentell: Cryotherapy
Participants received local cryotherapy over the hamstring muscles 24 hours after eccentric exercise-induced delayed onset muscle soreness.
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Participants were placed in prone position and an ice pack was applied over the hamstring muscles for 20 minutes.
A thin cloth was placed between the ice pack and the skin to avoid direct contact.
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Placebo-jämförare: water with sugar
Participants received a placebo intervention consisting of water with sugar 24 hours after eccentric exercise-induced delayed onset muscle soreness.
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Participants consumed 200 mL of water with 5 g of dissolved sugar after the eccentric exercise protocol.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Change in Pressure Pain Threshold in the Hamstring Muscles
Tidsram: Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Pressure pain threshold was assessed using a pressure algometer over three points of maximum pain in the hamstring muscles.
Three measurements were taken and the mean value was calculated.
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Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Change in Active Knee Range of Motion
Tidsram: Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Active knee flexion and extension range of motion were assessed using a manual goniometer.
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Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Change in Hamstring Muscle Strength
Tidsram: Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Maximum hamstring strength was assessed using a handheld dynamometer.
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Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Change in Blood Lactate Concentration
Tidsram: Before exercise, immediately after exercise, and 48 hours after exercise
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Blood lactate concentration was measured using a Lactate Edge device.
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Before exercise, immediately after exercise, and 48 hours after exercise
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Change in Pain Intensity
Tidsram: Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Pain intensity was assessed using the 11-point Numeric Pain Rating Scale.
Scores range from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain.
Higher scores indicate greater pain intensity and therefore a worse outcome.
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Baseline, 24 hours after eccentric exercise before treatment, immediately after treatment, and 48 hours after eccentric exercise
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Perceived Exertion After Eccentric Exercise
Tidsram: Immediately after eccentric exercise
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Perceived exertion was assessed using the Modified Borg Rating of Perceived Exertion Scale after completion of the eccentric exercise protocol.
Scores range from 0 to 10, where 0 indicates no exertion and 10 indicates maximal exertion.
Higher scores indicate greater perceived exertion and therefore a worse outcome.
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Immediately after eccentric exercise
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Utredare
- Huvudutredare: Sara Perpiña Martínez, PhD, Universidad Pontificia de Salamanca
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
1 januari 2025
Primärt slutförande (Faktisk)
26 april 2025
Avslutad studie (Faktisk)
30 april 2025
Studieregistreringsdatum
Först inskickad
28 maj 2026
Först inskickad som uppfyllde QC-kriterierna
28 maj 2026
Första postat (Faktisk)
3 juni 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
16 juni 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
13 juni 2026
Senast verifierad
1 juni 2026
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
- Neurologiska manifestationer
- Patologiska tillstånd, tecken och symtom
- Tecken och symtom
- Smärta
- Motorisk aktivitet
- Rörelse
- Muskuloskeletala fysiologiska fenomen
- Muskuloskeletala och neurala fysiologiska fenomen
- Terapeutik
- Fysioterapimetoder
- Kolhydrater
- Patientvård
- Träningsterapi
- Rehabilitering
- Eftervård
- Kontinuitet i patientvård
- Utöva
- Socker
- Muskelsträckningsövningar
Andra studie-ID-nummer
- UPSA-DOMS-2025
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
JA
IPD-planbeskrivning
De-identified individual participant data related to the outcomes reported in the study may be shared upon reasonable request to the principal investigator.
Data will only be shared for academic and research purposes, after approval by the study team, and in accordance with applicable data protection regulations.
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Nej
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
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