Evaluating How Well Different Types of Light-sensitive Cells in the Eye Contribute to Its Focusing Ability
2026年7月15日 更新者：Benjamin Chin、Rochester Institute of Technology
A Randomized, Repeated-measures Study to Evaluate the Contributions of Different Cone Photoreceptor Classes to a Step Ocular Accommodation Task
In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes.
The shapes will look as though they are jumping to random distances away from the eye.
As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor.
This device uses infrared light to measure the optical properties of the eye in real time.
Our goal is to find out how well the eye focuses on different colors.
Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.
研究概览
地位
招聘中
条件
干预/治疗
详细说明
In this experiment, subjects will view Gabor patterns on a display through a Badal relay.
The Gabor patterns will vary in their color.
The colors will be picked to selectively modulate cone photoreceptor activity in different directions in cone contrast space.
Subjects will be instructed to accommodate to the patterns while the virtual distance of the screen is manipulated with a focus-adjustable lens.
As they do so, the investigators will measure the wavefronts of their eyes using a Shack-Hartmann wavefront sensor.
研究类型
介入性
注册 (估计的)
20
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Benjamin M Chin, Doctorate
- 电话号码：8454534320
- 邮箱：bmccis@rit.edu
学习地点
-
-
New York
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Rochester、New York、美国、14623
- 招聘中
- Chester F. Carlson Center for Imaging Science
-
接触：
- Benjamin M Chin, Doctorate
- 电话号码：8454534320
- 邮箱：bmccis@rit.edu
-
首席研究员：
- Benjamin M Chin, Doctorate
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 孩子
- 成人
接受健康志愿者
是的
描述
Inclusion Criteria:
- Between 18-35 years of age
- Normal or corrected-to-normal (glasses/contact lenses) vision.
Exclusion Criteria:
- Vision worse than 20/20 while wearing glasses / contact lenses.
- Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)
- Current pregnancy (experiment requires sitting down without moving for stretches of time)
- Heart disease
- Personal/familial history of epilepsy
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Color variation in visual stimulus
Each participant undergoes all experimental conditions, in a within-subjects design.
Each intervention corresponds to a different stimulus color.
The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.
|
Each intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus.
The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Accuracy of ocular accommodation
大体时间：Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
|
Ocular accommodation is the focusing response of the lens in the eye.
When the stimulus viewed by the participant changes in distance, the eye automatically refocuses.
The investigators measure this refocusing using a device called a wavefront sensor.
The investigators are particularly interested in how accurate this refocusing is, which is measured in units of diopters.
|
Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
|
|
Speed of ocular accommodation
大体时间：Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
|
The investigators are interested in how quickly the eye refocuses when a near object moves farther away.
Typically, this process takes around 1 second, but it can take longer or shorter depending on the individual and on the object being viewed.
By analyzing data collected by the wavefront sensor, the investigators will calculate how long it took for the eye to refocus during each measurement.
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Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年7月2日
初级完成 (估计的)
2026年12月15日
研究完成 (估计的)
2026年12月15日
研究注册日期
首次提交
2026年6月30日
首先提交符合 QC 标准的
2026年7月6日
首次发布 (实际的)
2026年7月9日
研究记录更新
最后更新发布 (实际的)
2026年7月17日
上次提交的符合 QC 标准的更新
2026年7月15日
最后验证
2026年7月1日
更多信息
与本研究相关的术语
其他研究编号
- IRB0000131-Exp1
- 4R00EY036497-03 (美国 NIH 拨款/合同)
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
未定
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.