Evaluating How Well Different Types of Light-sensitive Cells in the Eye Contribute to Its Focusing Ability
15. juli 2026 oppdatert av: Benjamin Chin, Rochester Institute of Technology
A Randomized, Repeated-measures Study to Evaluate the Contributions of Different Cone Photoreceptor Classes to a Step Ocular Accommodation Task
In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes.
The shapes will look as though they are jumping to random distances away from the eye.
As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor.
This device uses infrared light to measure the optical properties of the eye in real time.
Our goal is to find out how well the eye focuses on different colors.
Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.
Studieoversikt
Status
Rekruttering
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
In this experiment, subjects will view Gabor patterns on a display through a Badal relay.
The Gabor patterns will vary in their color.
The colors will be picked to selectively modulate cone photoreceptor activity in different directions in cone contrast space.
Subjects will be instructed to accommodate to the patterns while the virtual distance of the screen is manipulated with a focus-adjustable lens.
As they do so, the investigators will measure the wavefronts of their eyes using a Shack-Hartmann wavefront sensor.
Studietype
Intervensjonell
Registrering (Antatt)
20
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: Benjamin M Chin, Doctorate
- Telefonnummer: 8454534320
- E-post: bmccis@rit.edu
Studiesteder
-
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New York
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Rochester, New York, Forente stater, 14623
- Rekruttering
- Chester F. Carlson Center for Imaging Science
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Ta kontakt med:
- Benjamin M Chin, Doctorate
- Telefonnummer: 8454534320
- E-post: bmccis@rit.edu
-
Hovedetterforsker:
- Benjamin M Chin, Doctorate
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Barn
- Voksen
Tar imot friske frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Between 18-35 years of age
- Normal or corrected-to-normal (glasses/contact lenses) vision.
Exclusion Criteria:
- Vision worse than 20/20 while wearing glasses / contact lenses.
- Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)
- Current pregnancy (experiment requires sitting down without moving for stretches of time)
- Heart disease
- Personal/familial history of epilepsy
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Eksperimentell: Color variation in visual stimulus
Each participant undergoes all experimental conditions, in a within-subjects design.
Each intervention corresponds to a different stimulus color.
The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.
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Each intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus.
The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Accuracy of ocular accommodation
Tidsramme: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
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Ocular accommodation is the focusing response of the lens in the eye.
When the stimulus viewed by the participant changes in distance, the eye automatically refocuses.
The investigators measure this refocusing using a device called a wavefront sensor.
The investigators are particularly interested in how accurate this refocusing is, which is measured in units of diopters.
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Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
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Speed of ocular accommodation
Tidsramme: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
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The investigators are interested in how quickly the eye refocuses when a near object moves farther away.
Typically, this process takes around 1 second, but it can take longer or shorter depending on the individual and on the object being viewed.
By analyzing data collected by the wavefront sensor, the investigators will calculate how long it took for the eye to refocus during each measurement.
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Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Samarbeidspartnere
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
2. juli 2026
Primær fullføring (Antatt)
15. desember 2026
Studiet fullført (Antatt)
15. desember 2026
Datoer for studieregistrering
Først innsendt
30. juni 2026
Først innsendt som oppfylte QC-kriteriene
6. juli 2026
Først lagt ut (Faktiske)
9. juli 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
17. juli 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
15. juli 2026
Sist bekreftet
1. juli 2026
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- IRB0000131-Exp1
- 4R00EY036497-03 (U.S. NIH-stipend/kontrakt)
Plan for individuelle deltakerdata (IPD)
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