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Predictors of Mortality in Cirrhotic Patients With Acute Kidney Injury

2026年8月30日更新者：Mohamed Emad el-din Salah、Assiut University

Clinical and Laboratory Predictors of Short-Term Mortality in Cirrhotic Patients With Acute Kidney Injury

Acute kidney injury (AKI) is a common and severe complication in patients with liver cirrhosis, significantly increasing the risk of short-term mortality. Early identification of clinical and laboratory predictors of mortality in these patients is crucial for risk stratification and optimizing clinical management.

This study aims to identify the key clinical parameters (such as the presence of ascites, hepatic encephalopathy, and hemodynamics) and laboratory markers (such as serum creatinine, bilirubin, albumin, sodium, and INR) that predict short-term mortality in cirrhotic patients presenting with AKI. The findings will assist clinicians in recognizing high-risk patients early and tailoring targeted therapeutic interventions .

研究概览

地位

尚未招聘

条件

肝硬化中的急性肾损伤

详细说明

Cirrhosis-associated acute kidney injury (AKI) represents a major prognostic milestone in the clinical course of end-stage liver disease. While baseline scoring systems like the Model for End-Stage Liver Disease (MELD) and Child-Pugh score provide overall prognostic value, specific clinical and dynamic laboratory predictors are needed to refine short-term mortality risk assessment in the context of AKI.

Objectives:

To evaluate the clinical presentation and laboratory parameters of cirrhotic patients at the time of AKI diagnosis.
To determine independent clinical and laboratory factors associated with short-term mortality.
To assess the predictive performance of clinical scoring systems in this specific cohort.

Methodology:

This observational study will enroll patients diagnosed with liver cirrhosis and AKI based on International Club of Ascites (ICA-AKI) criteria. Comprehensive clinical evaluations and laboratory investigations will be recorded at baseline/admission. Patients will be followed up for [30 / 90 days] to assess clinical outcomes, including survival, recovery of renal function, or mortality. Multivariate statistical analysis will be applied to identify independent mortality predictors.

研究类型

观察性的

注册 (估计的)

100

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：mohamed emad salah, MBBCh
电话号码：+201005127591
邮箱：muhamed.emad19@icloud.com

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

孩子
成人
年长者

接受健康志愿者

不

取样方法

非概率样本

研究人群

This study targets adult patients diagnosed with liver cirrhosis who develop acute kidney injury (AKI) during their admission or evaluation at the gastroenterology and hepatology departments or intensive care units. Diagnosis of liver cirrhosis is established based on clinical, laboratory, and ultrasonographic findings. Acute kidney injury is defined and staged according to the International Club of Ascites (ICA-AKI) or KDIGO criteria. The population reflects real-world clinical presentations of decompensated cirrhotic patients requiring urgent medical evaluation for renal impairment.

描述

Inclusion Criteria:

Adults aged ≥ 18 years.
Hospitalized cirrhotic patients who develop AKI and mortality occurs within 30 days of the development of AKI

Exclusion Criteria:

Patients younger than 18 years
Patients with HIV infection.
Patients with previous liver transplantation.
Patients with incomplete clinical or laboratory data
Patients with end-stage chronic kidney disease on maintenance dialysis.
Patients with acute liver failure without underlying liver cirrhosis

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列
Cirrhotic Patients

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Short-term mortality 大体时间：From hospital admission up to hospital discharge, an average of 2 weeks	Mortality among cirrhotic patients presenting with acute kidney injury	From hospital admission up to hospital discharge, an average of 2 weeks

次要结果测量

结果测量	措施说明	大体时间
Serum creatinine associated with in-hospital mortality 大体时间：From hospital admission up to hospital discharge, an average of 2 weeks	Serum creatinine will be assessed at hospital admission and its association with in-hospital mortality will be evaluated.	From hospital admission up to hospital discharge, an average of 2 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Assiut University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年10月1日

初级完成 (估计的)

2026年10月1日

研究完成 (估计的)

2027年10月1日

研究注册日期

首次提交

2026年8月23日

首先提交符合 QC 标准的

2026年8月30日

首次发布 (实际的)

2026年9月1日

研究记录更新

最后更新发布 (实际的)