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Predictors of Mortality in Cirrhotic Patients With Acute Kidney Injury

30. august 2026 oppdatert av: Mohamed Emad el-din Salah, Assiut University

Clinical and Laboratory Predictors of Short-Term Mortality in Cirrhotic Patients With Acute Kidney Injury

Acute kidney injury (AKI) is a common and severe complication in patients with liver cirrhosis, significantly increasing the risk of short-term mortality. Early identification of clinical and laboratory predictors of mortality in these patients is crucial for risk stratification and optimizing clinical management.

This study aims to identify the key clinical parameters (such as the presence of ascites, hepatic encephalopathy, and hemodynamics) and laboratory markers (such as serum creatinine, bilirubin, albumin, sodium, and INR) that predict short-term mortality in cirrhotic patients presenting with AKI. The findings will assist clinicians in recognizing high-risk patients early and tailoring targeted therapeutic interventions .

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

AKI ved cirrose

Detaljert beskrivelse

Cirrhosis-associated acute kidney injury (AKI) represents a major prognostic milestone in the clinical course of end-stage liver disease. While baseline scoring systems like the Model for End-Stage Liver Disease (MELD) and Child-Pugh score provide overall prognostic value, specific clinical and dynamic laboratory predictors are needed to refine short-term mortality risk assessment in the context of AKI.

Objectives:

To evaluate the clinical presentation and laboratory parameters of cirrhotic patients at the time of AKI diagnosis.
To determine independent clinical and laboratory factors associated with short-term mortality.
To assess the predictive performance of clinical scoring systems in this specific cohort.

Methodology:

This observational study will enroll patients diagnosed with liver cirrhosis and AKI based on International Club of Ascites (ICA-AKI) criteria. Comprehensive clinical evaluations and laboratory investigations will be recorded at baseline/admission. Patients will be followed up for [30 / 90 days] to assess clinical outcomes, including survival, recovery of renal function, or mortality. Multivariate statistical analysis will be applied to identify independent mortality predictors.

Studietype

Observasjonsmessig

Registrering (Antatt)

100

Kontakter og plasseringer

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Studiekontakt

Navn: mohamed emad salah, MBBCh
Telefonnummer: +201005127591
E-post: muhamed.emad19@icloud.com

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Barn
Voksen
Eldre voksen

Tar imot friske frivillige

Nei

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

This study targets adult patients diagnosed with liver cirrhosis who develop acute kidney injury (AKI) during their admission or evaluation at the gastroenterology and hepatology departments or intensive care units. Diagnosis of liver cirrhosis is established based on clinical, laboratory, and ultrasonographic findings. Acute kidney injury is defined and staged according to the International Club of Ascites (ICA-AKI) or KDIGO criteria. The population reflects real-world clinical presentations of decompensated cirrhotic patients requiring urgent medical evaluation for renal impairment.

Beskrivelse

Inclusion Criteria:

Adults aged ≥ 18 years.
Hospitalized cirrhotic patients who develop AKI and mortality occurs within 30 days of the development of AKI

Exclusion Criteria:

Patients younger than 18 years
Patients with HIV infection.
Patients with previous liver transplantation.
Patients with incomplete clinical or laboratory data
Patients with end-stage chronic kidney disease on maintenance dialysis.
Patients with acute liver failure without underlying liver cirrhosis

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Antall grupper / kohorter

Kohorter og intervensjoner

Gruppe / Kohort
Cirrhotic Patients

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Short-term mortality Tidsramme: From hospital admission up to hospital discharge, an average of 2 weeks	Mortality among cirrhotic patients presenting with acute kidney injury	From hospital admission up to hospital discharge, an average of 2 weeks

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Serum creatinine associated with in-hospital mortality Tidsramme: From hospital admission up to hospital discharge, an average of 2 weeks	Serum creatinine will be assessed at hospital admission and its association with in-hospital mortality will be evaluated.	From hospital admission up to hospital discharge, an average of 2 weeks

Samarbeidspartnere og etterforskere

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Sponsor

Assiut University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

1. oktober 2026

Primær fullføring (Antatt)

1. oktober 2026

Studiet fullført (Antatt)

1. oktober 2027

Datoer for studieregistrering

Først innsendt

23. august 2026

Først innsendt som oppfylte QC-kriteriene

30. august 2026

Først lagt ut (Faktiske)

1. september 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)