Comparison Between Dentine Autograft VS Platelet Rich Fibrin in Extraction Socket Bone Healing
2026年8月27日 更新者:Eman abdelbaki、Cairo University
Histomorphological Evaluation of Alveolar Bone Healing Using Dentin Autograft Mixed With Platelet-rich Fibrin in Extraction Socket vs Graftless Healing
The present study will be performed to:
evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing.
研究概览
地位
完全的
详细说明
When teeth are extracted, a certain amount of bone loss or resorption occurs, usually about 30-60%.
This loss is typically three-dimensional in nature, with width loss or horizontal deficiency developing to a greater extent than other types of deficiencies.
An alveolar defect can be classified as the loss of labial or buccal cortical or medullary bone.
In some cases, both exist.
Although all alveolar defects present challenges when planning a dental implant procedure, if the defect is in the buccal cortex or cortical plate after tooth extraction, this can create significant difficulties in the reconstruction of a dental implant.
Bone loss or bone augmentation techniques have been developed to counteract alveolar defects, such as guided bone regeneration, onlay block bone grafting, ridge/split bone grafting, and alveolar distraction osteogenesis.
These procedures can help improve an alveolar defect and prepare the alveolar ridge for a successful dental implant.
研究类型
介入性
注册 (实际的)
45
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
-
Cairo Governorate
-
Cairo、Cairo Governorate、埃及、11553
- Faculty of Dentistry, Cairo University
-
-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
不
描述
Inclusion Criteria:
- 1. Patients with hopeless non molar teeth that need extraction. 2. Age above 18 years. 3. Generally good state of health. 4. Agreement to participate in the study and also have to be able to attend postoperative clinical and radiological follow-up 6. Acquisition of informed consent.
Exclusion Criteria:
1- Patients refuse to be enrolled in this study
2- Patients with uncontrolled systemic disease.
3- Previously diagnosed hematological and neurological conditions.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:预防
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
无干预:Graftless Healing (Control)
Participants undergo atraumatic extraction of a hopeless non-molar tooth.
The extraction socket is left to heal spontaneously without placement of any grafting material.
The socket is sutured with 3-0 Vicryl to allow primary wound closure.
Clinical, radiographic, and histomorphometric evaluations are performed according to the study follow-up schedule.
|
|
|
实验性的:Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP)
Participants undergo atraumatic extraction of a hopeless non-molar tooth followed by immediate socket preservation using an autogenous dentin graft prepared from the extracted tooth.
The dentin particles are processed using the Smart Dentin Grinder system, disinfected, rinsed with phosphate-buffered saline, and mixed with autologous platelet-rich plasma (PRP) to produce a sticky dentin graft.
The graft is placed into the extraction socket, and the surgical site is sutured with 3-0 Vicryl.
Clinical, radiographic, and histomorphometric outcomes are evaluated throughout the follow-up period.
|
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
|
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实验性的:Platelets rich fibrin applied in the socket
PRF from patient own blood is applied to the socket
|
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Histomorphometric bone formation (%)
大体时间:3-6 months
|
a trephine bur is used to extract a sample from healed bone to be stained with H&E and analyzed under microscope
|
3-6 months
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Bone density (radiographic) Healing index
大体时间:3-6 months
|
type of bone is measerd on cbct scan after three months from healing of bone
|
3-6 months
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2023年1月1日
初级完成 (实际的)
2026年1月13日
研究完成 (实际的)
2026年7月1日
研究注册日期
首次提交
2026年8月27日
首先提交符合 QC 标准的
2026年8月27日
首次发布 (实际的)
2026年9月1日
研究记录更新
最后更新发布 (实际的)
2026年9月1日
上次提交的符合 QC 标准的更新
2026年8月27日
最后验证
2026年7月1日
更多信息
与本研究相关的术语
其他研究编号
- Dentine autograft vs PRF
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
不
IPD 计划说明
Individual participant data (IPD) will not be shared because the study was not designed with participant-level data sharing.
The collected data contain confidential information, and participants did not provide consent for public sharing of de-identified individual-level data.
Only aggregate study results will be published.
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.