Comparison Between Dentine Autograft VS Platelet Rich Fibrin in Extraction Socket Bone Healing
27. august 2026 oppdatert av: Eman abdelbaki, Cairo University
Histomorphological Evaluation of Alveolar Bone Healing Using Dentin Autograft Mixed With Platelet-rich Fibrin in Extraction Socket vs Graftless Healing
The present study will be performed to:
evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing.
Studieoversikt
Status
Fullført
Detaljert beskrivelse
When teeth are extracted, a certain amount of bone loss or resorption occurs, usually about 30-60%.
This loss is typically three-dimensional in nature, with width loss or horizontal deficiency developing to a greater extent than other types of deficiencies.
An alveolar defect can be classified as the loss of labial or buccal cortical or medullary bone.
In some cases, both exist.
Although all alveolar defects present challenges when planning a dental implant procedure, if the defect is in the buccal cortex or cortical plate after tooth extraction, this can create significant difficulties in the reconstruction of a dental implant.
Bone loss or bone augmentation techniques have been developed to counteract alveolar defects, such as guided bone regeneration, onlay block bone grafting, ridge/split bone grafting, and alveolar distraction osteogenesis.
These procedures can help improve an alveolar defect and prepare the alveolar ridge for a successful dental implant.
Studietype
Intervensjonell
Registrering (Faktiske)
45
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
-
-
Cairo Governorate
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Cairo, Cairo Governorate, Egypt, 11553
- Faculty of Dentistry, Cairo University
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Nei
Beskrivelse
Inclusion Criteria:
- 1. Patients with hopeless non molar teeth that need extraction. 2. Age above 18 years. 3. Generally good state of health. 4. Agreement to participate in the study and also have to be able to attend postoperative clinical and radiological follow-up 6. Acquisition of informed consent.
Exclusion Criteria:
1- Patients refuse to be enrolled in this study
2- Patients with uncontrolled systemic disease.
3- Previously diagnosed hematological and neurological conditions.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Forebygging
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
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Ingen inngripen: Graftless Healing (Control)
Participants undergo atraumatic extraction of a hopeless non-molar tooth.
The extraction socket is left to heal spontaneously without placement of any grafting material.
The socket is sutured with 3-0 Vicryl to allow primary wound closure.
Clinical, radiographic, and histomorphometric evaluations are performed according to the study follow-up schedule.
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|
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Eksperimentell: Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP)
Participants undergo atraumatic extraction of a hopeless non-molar tooth followed by immediate socket preservation using an autogenous dentin graft prepared from the extracted tooth.
The dentin particles are processed using the Smart Dentin Grinder system, disinfected, rinsed with phosphate-buffered saline, and mixed with autologous platelet-rich plasma (PRP) to produce a sticky dentin graft.
The graft is placed into the extraction socket, and the surgical site is sutured with 3-0 Vicryl.
Clinical, radiographic, and histomorphometric outcomes are evaluated throughout the follow-up period.
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DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
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Eksperimentell: Platelets rich fibrin applied in the socket
PRF from patient own blood is applied to the socket
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DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Histomorphometric bone formation (%)
Tidsramme: 3-6 months
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a trephine bur is used to extract a sample from healed bone to be stained with H&E and analyzed under microscope
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3-6 months
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Bone density (radiographic) Healing index
Tidsramme: 3-6 months
|
type of bone is measerd on cbct scan after three months from healing of bone
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3-6 months
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
1. januar 2023
Primær fullføring (Faktiske)
13. januar 2026
Studiet fullført (Faktiske)
1. juli 2026
Datoer for studieregistrering
Først innsendt
27. august 2026
Først innsendt som oppfylte QC-kriteriene
27. august 2026
Først lagt ut (Faktiske)
1. september 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
1. september 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
27. august 2026
Sist bekreftet
1. juli 2026
Mer informasjon
Begreper knyttet til denne studien
Andre studie-ID-numre
- Dentine autograft vs PRF
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
IPD-planbeskrivelse
Individual participant data (IPD) will not be shared because the study was not designed with participant-level data sharing.
The collected data contain confidential information, and participants did not provide consent for public sharing of de-identified individual-level data.
Only aggregate study results will be published.
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
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