Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study (HYSTERESIS)
To evaluate the ability of exercise ECG to discriminate between hypertensive heart disease-related and CAD-related abnormalities
研究概览
详细说明
In this prospective study, consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA).
Patients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD:
LVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD
LVH will be defined by standard echocardiographic criteria, while obstructive CAD will be assessed by CCTA. Stress CMR will serve as the reference standard for inducible myocardial ischemia.
Exercise ECG parameters will include conventional ST-segment criteria as well as dynamic indices during exercise and recovery. Associations between ECG findings and imaging-defined phenotypes will be evaluated, and predictors of CAD-related ischemia will be identified.
Results The study will assess the diagnostic performance of exercise ECG across the four predefined groups. Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia.
研究类型
注册 (估计的)
联系人和位置
学习地点
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PI
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Pisa、PI、意大利、56124
- 招聘中
- Azienda Ospedaliero-Universitaria Pisana
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接触：
- Mattia Alberti, MD, PhD candidate
- 电话号码：+39 3770805335
- 邮箱：mattia.alberti@phd.unipi.it
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接触：
- Morrone Doralisa, MD, PhD, Associate Professor
- 邮箱：doralisa.morrone@unipi.it
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副研究员：
- Riccardo Canonaco, MD
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副研究员：
- Simona Chiusolo, MD
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副研究员：
- Simona Buralli, MD
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副研究员：
- Stefano Taddei, MD, Full Professor
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副研究员：
- Emanuele Neri, MD, Full Professor
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副研究员：
- Giovanni Donato Aquaro, MD, PhD, Associate Professor
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副研究员：
- Lorenzo Faggioni, MD, Associate Professor
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副研究员：
- Doralisa Morrone, MD, PhD, Associate Professor
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副研究员：
- Raffaele De Caterina, MD, PhD, Full Professor
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副研究员：
- Pietro Lucii, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA).
Patients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD:
LVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD
描述
Inclusion Criteria:
- Patients with CAD and LVH
Exclusion Criteria:
- Patients with RBBB
学习计划
研究是如何设计的？
设计细节
- 观测模型：COHORT
- 时间观点：PROSPECTIVE
队列和干预
团体/队列 |
|---|
|
LVH with obstructive CAD
LVH with obstructive CAD |
|
LVH without obstructive CAD
LVH without obstructive CAD |
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No LVH with obstructive CAD
No LVH with obstructive CAD |
|
No LVH without obstructive CAD
No LVH without obstructive CAD |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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diagnostic performance of exercise ECG across the four predefined groups.
大体时间：From enrollment through completion of all diagnostic evaluations, assessed up to 3 months after enrollment.
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Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia. |
From enrollment through completion of all diagnostic evaluations, assessed up to 3 months after enrollment.
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- HYSTERESIS
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
Individual participant data (IPD) will be made available upon reasonable request following the completion of all planned analyses and subsequent publication of the resulting manuscripts
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